Age-Dependent Decline in β-Cell Proliferation Restricts the Capacity of β-Cell Regeneration in MiceTSCHEN, Shuen-Ing; DHAWAN, Sangeeta; GURLO, Tatyana et al.Diabetes (New York, NY). 2009, Vol 58, Num 6, pp 1312-1320, issn 0012-1797, 9 p.Article

β-Cell Failure in Type 2 Diabetes: A Case of Asking Too Much of Too Few?COSTES, Safia; LANGEN, Ralf; GURLO, Tatyana et al.Diabetes (New York, NY). 2013, Vol 62, Num 2, pp 327-335, issn 0012-1797, 9 p.Article

Cyclin-Dependent Kinase 5 Promotes Pancreatic β-Cell Survival via Fak-Akt Signaling PathwaysDAVAL, Marie; GURLO, Tatyana; COSTES, Safia et al.Diabetes (New York, NY). 2011, Vol 60, Num 4, pp 1186-1197, issn 0012-1797, 12 p.Article

Successful Versus Failed Adaptation to High-Fat Diet-Induced Insulin Resistance : The Role of IAPP-Induced β-Cell Endoplasmic Reticulum StressMATVEYENKO, Aleksey V; GURLO, Tatyana; DAVAL, Marie et al.Diabetes (New York, NY). 2009, Vol 58, Num 4, pp 906-916, issn 0012-1797, 11 p.Article

Activation of peroxisome proliferator-activated receptor-γ by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3'-kinase-dependent pathwayLIN, Chia-Yu; GURLO, Tatyana; HAATAJA, Leena et al.The Journal of clinical endocrinology and metabolism. 2005, Vol 90, Num 12, pp 6678-6686, issn 0021-972X, 9 p.Article

Induction of endoplasmic reticulum stress-induced β-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptideHUANG, Chang-Jiang; HAATAJA, Leena; GURLO, Tatyana et al.American journal of physiology. Endocrinology and metabolism. 2007, Vol 56, Num 6, issn 0193-1849, E1656-E1662Article

Development of factors to convert frequency to rate for β-cell replication and apoptosis quantified by time-lapse video microscopy and immunohistochemistrySAISHO, Yoshifumi; MANESSO, Erica; GURLO, Tatyana et al.American journal of physiology. Endocrinology and metabolism. 2009, Vol 59, Num 1, issn 0193-1849, E89-E96Article

Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine TumorsBUTLER, Alexandra E; CAMPBELL-THOMPSON, Martha; GURLO, Tatyana et al.Diabetes (New York, NY). 2013, Vol 62, Num 7, pp 2595-2604, issn 0012-1797, 10 p.Article

Pulsatile Portal Vein Insulin Delivery Enhances Hepatic Insulin Action and SignalingMATVEYENKO, Aleksey V; LIUWANTARA, David; BUTLER, Peter C et al.Diabetes (New York, NY). 2012, Vol 61, Num 9, pp 2269-2279, issn 0012-1797, 11 p.Article

Beneficial Endocrine but Adverse Exocrine Effects of Sitagliptin in the Human Islet Amyloid Polypeptide Transgenic Rat Model of Type 2 Diabetes: Interactions With MetforminMATVEYENKO, Aleksey V; DRY, Sarah; COX, Heather I et al.Diabetes (New York, NY). 2009, Vol 58, Num 7, pp 1604-1615, issn 0012-1797, 12 p.Article

Diabetes due to a progressive defect in β-cell mass in rats transgenic for human islet amyloid polypeptide (HIP rat): A new model for type 2 diabetesBUTLER, Alexandra E; JANG, Jennifer; GURLO, Tatyana et al.Diabetes (New York, NY). 2004, Vol 53, Num 6, pp 1509-1516, issn 0012-1797, 8 p.Article

Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-Induced β-Cell apoptosis in h-IAPP transgenic miceLIN, Chia-Yu; GURLO, Tatyana; KAYED, Rakez et al.Diabetes (New York, NY). 2007, Vol 56, Num 5, pp 1324-1332, issn 0012-1797, 9 p.Article

Ongoing β-Cell Turnover in Adult Nonhuman Primates Is Not Adaptively Increased in Streptozotocin-Induced DiabetesSAISHO, Yoshifumi; MANESSO, Erica; COBELLI, Claudio et al.Diabetes (New York, NY). 2011, Vol 60, Num 3, pp 848-856, issn 0012-1797, 9 p.Article

β-Cell Dysfunctional ERAD/Ubiquitin/Proteasome System in Type 2 Diabetes Mediated by Islet Amyloid Polypeptide-Induced UCH-L1 DeficiencyCOSTES, Safia; HUANG, Chang-Jiang; GURLO, Tatyana et al.Diabetes (New York, NY). 2011, Vol 60, Num 1, pp 227-238, issn 0012-1797, 12 p.Article

Evidence for Proteotoxicity in β Cells in Type 2 Diabetes: Toxic Islet Amyloid Polypeptide Oligomers Form Intracellularly in the Secretory PathwayGURLO, Tatyana; RYAZANTSEV, Sergey; HUANG, Chang-Jiang et al.The American journal of pathology. 2010, Vol 176, Num 2, pp 861-869, issn 0002-9440, 9 p.Article

Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer HypothesisHAATAJA, Leena; GURLO, Tatyana; HUANG, Chang J et al.Endocrine reviews. 2008, Vol 29, Num 3, pp 303-316, issn 0163-769X, 14 p.Article

High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress-mediated β-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetesHUANG, Chang-Jiang; LIN, Chia-Yu; HAATAJA, Leena et al.Diabetes (New York, NY). 2007, Vol 56, Num 8, pp 2016-2027, issn 0012-1797, 12 p.Article