Gastrointestinal transit and drug absorptionKIMURA, Toshikiro; HIGAKI, Kazutaka.Biological & pharmaceutical bulletin. 2002, Vol 25, Num 2, pp 149-164, issn 0918-6158Article

Gastrointestinal transit and drug absorptionKIMURA, Toshikiro; HIGAKI, Kazutaka.Biological & pharmaceutical bulletin. 2002, Vol 25, Num 2, pp 149-164, issn 0918-6158Article

Regulation system of serine protease production in Vibrio vulnificus strain NCIMB 2137, a metalloprotease-gene negative strain isolated from a diseased eelELGAML, Abdelaziz; HIGAKI, Kazutaka; MIYOSHI, Shin-Ichi et al.Aquaculture (Amsterdam). 2013, Vol 416-417, pp 315-321, issn 0044-8486, 7 p.Article

Time-dependent oral absorption modelsHIGAKI, Kazutaka; YAMASHITA, Shinji; AMIDON, Gordon L et al.Journal of pharmacokinetics and biopharmaceutics. 2001, Vol 28, Num 2, pp 109-128, issn 0090-466XArticle

Major determinants in hepatic disposition of polystyrene nanospheres: Implication for rational design of particulate drug carriersOGAWARA, Ken-Ichi; HIGAKI, Kazutaka; KIMURA, Toshikiro et al.Critical reviews in therapeutic drug carrier systems. 2002, Vol 19, Num 4-5, pp 277-306, issn 0743-4863, 30 p.Article

Animal models for predicting potency of oral sustained-release adhesive microspheres in humansNAGAHARA, Naoki; AKIYAMA, Yohko; HIGAKI, Kazutaka et al.International journal of pharmaceutics. 2007, Vol 331, Num 1, pp 46-53, issn 0378-5173, 8 p.Article

Evaluation of sustained release suppositories prepared with fatty base including solid fats with high melting pointsTAKATORI, Toshihito; SHIMONO, Norihito; HIGAKI, Kazutaka et al.International journal of pharmaceutics. 2004, Vol 278, Num 2, pp 275-282, issn 0378-5173, 8 p.Article

Prolongation of residence time of liposome by surface-modification with mixture of hydrophilic polymersSHEHATA, Tamer; OGAWARA, Ken-Ichi; HIGAKI, Kazutaka et al.International journal of pharmaceutics. 2008, Vol 359, Num 1-2, pp 272-279, issn 0378-5173, 8 p.Article

Casein enhances stability of peptides in intestinal lumen: Role of digested products of caseinOHTANI, Seiji; OGAWARA, Ken-Ichi; HIGAKI, Kazutaka et al.Pharmaceutical research. 2003, Vol 20, Num 11, pp 1746-1751, issn 0724-8741, 6 p.Article

In vivo anti-tumor effect of PEG liposomal doxorubicin (DOX) in DOX-resistant tumor-bearing mice : Involvement of cytotoxic effect on vascular endothelial cellsOGAWARA, Ken-Ichi; UN, Keita; TANAKA, Ken-Ichi et al.Journal of controlled release. 2009, Vol 133, Num 1, pp 4-10, issn 0168-3659, 7 p.Article

Evaluation of in vivo dissolution behavior and GI transit of griseofulvin, a BCS class II drugFUJIOKA, Yoshitsugu; METSUGI, Yukiko; OGAWARA, Ken-Ichi et al.International journal of pharmaceutics. 2008, Vol 352, Num 1-2, pp 36-43, issn 0378-5173, 8 p.Article

Skin permeation of propranolol from polymeric film containing terpene enhancers for transdermal useAMNUAIKIT, Chomchan; IKEUCHI, Itsue; OGAWARA, Ken-Ichi et al.International journal of pharmaceutics. 2005, Vol 289, Num 1-2, pp 167-178, issn 0378-5173, 12 p.Article

Amino Acids Suppress Apoptosis Induced by Sodium Laurate, An Absorption EnhancerTAKAYAMA, Chie; MUKAIZAWA, Fuyuki; FUJITA, Takuya et al.Journal of pharmaceutical sciences. 2009, Vol 98, Num 12, pp 4629-4638, issn 0022-3549, 10 p.Article

Time-dependent changes in opsonin amount associated on nanoparticles alter their hepatic uptake characteristicsNAGAYAMA, Susumu; OGAWARA, Ken-Ichi; FUKUOKA, Yoshiko et al.International journal of pharmaceutics. 2007, Vol 342, Num 1-2, pp 215-221, issn 0378-5173, 7 p.Article

Amino acids protect epithelial cells from local toxicity by absorption enhancer, sodium laurateYATA, Takashi; ENDO, Yoko; SONE, Miki et al.Journal of pharmaceutical sciences. 2001, Vol 90, Num 10, pp 1456-1465, issn 0022-3549Article

PEG liposomalization of paclitaxel improved its in vivo disposition and anti-tumor efficacyYOSHIZAWA, Yuta; KONO, Yusuke; OGAWARA, Ken-Ichi et al.International journal of pharmaceutics (Print). 2011, Vol 412, Num 1-2, pp 132-141, issn 0378-5173, 10 p.Article

Estimation of intradermal disposition kinetics of drugs: II. Factors determining penetration of drugs from viable skin to muscular layerHIGAKI, Kazutaka; ASAI, Masahide; SUYAMA, Takayuki et al.International journal of pharmaceutics. 2002, Vol 239, Num 1-2, pp 129-141, issn 0378-5173Article

Quantitative Evaluation of PEPT1 Contribution to Oral Absorption of Cephalexin in RatsHIRONAKA, Takanori; ITOKAWA, Shota; OGAWARA, Ken-Ichi et al.Pharmaceutical research. 2009, Vol 26, Num 1, pp 40-50, issn 0724-8741, 11 p.Article

Appearance of Double Peaks in Plasma Concentration-time Profile after Oral Administration Depends on Gastric Emptying Profile and Weight FunctionMETSUGI, Yukiko; MIYAJI, Yoshihiro; OGAWARA, Ken-Ichi et al.Pharmaceutical research. 2008, Vol 25, Num 4, pp 886-895, issn 0724-8741, 10 p.Article

Determinants for in vivo anti-tumor effects of PEG liposomal doxorubicin: Importance of vascular permeability within tumorsOGAWARA, Ken-Ichi; UN, Keita; MINATO, Keiko et al.International journal of pharmaceutics. 2008, Vol 359, Num 1-2, pp 234-240, issn 0378-5173, 7 p.Article

Mechanistic understanding of time-dependent oral absorption based on gastric motor activity in humansHIGAKI, Kazutaka; CHOE, Sally Y; LÖBENBERG, Raimar et al.European journal of pharmaceutics and biopharmaceutics. 2008, Vol 70, Num 1, pp 313-325, issn 0939-6411, 13 p.Article

Evaluation of inhibitory activity of casein on proteases in rat intestineOHTANI, Seiji; SHIRASU, Kyoko; OGAWARA, Ken-Ichi et al.Pharmaceutical research. 2003, Vol 20, Num 4, pp 611-617, issn 0724-8741, 7 p.Article

Mechanisms of cytoprotective effect of amino acids on local toxicity caused by sodium laurate, a drug absorption enhancer, in intestinal epitheliumENDO, Yoko; HANADA, Kiyonori; MIYAKE, Masateru et al.Journal of pharmaceutical sciences. 2002, Vol 91, Num 3, pp 730-743, issn 0022-3549Article

Novel Comb-Shaped PEG Modification Enhances the Osteoclastic Inhibitory Effect and Bone Delivery of Osteoprotegerin After Intravenous Administration in Ovariectomized RatsMIYAJI, Yoshihiro; KASUYA, Yuji; FURUTA, Yoshitake et al.Pharmaceutical research. 2012, Vol 29, Num 11, pp 3143-3155, issn 0724-8741, 13 p.Article

Human jejunal permeability of cyclosporin A: Influence of surfactants on P-glycoprotein efflux in Caco-2 cellsCHIN, Yu-Yuan; HIGAKI, Kazutaka; NEUDECK, Brien L et al.Pharmaceutical research. 2003, Vol 20, Num 5, pp 749-756, issn 0724-8741, 8 p.Article