New players on the center stage : Sphingosine 1-phosphate and its receptors as drug targetsHUWILER, Andrea; PFEILSCHIFTER, Josef.Biochemical pharmacology. 2008, Vol 75, Num 10, pp 1893-1900, issn 0006-2952, 8 p.Article

Targeting the conversion of ceramide to sphingosine 1-phosphate as a novel strategy for cancer therapyHUWILER, Andrea; ZANGEMEISTER-WITTKE, Uwe.Critical reviews in oncology/hematology. 2007, Vol 63, Num 2, pp 150-159, issn 1040-8428, 10 p.Article

Altering the sphingosine-1-phosphate/ceramide balance : A promising approach for tumor therapyHUWILER, Andrea; PFEILSCHIFTER, Josef.Current pharmaceutical design. 2006, Vol 12, Num 35, pp 4625-4635, issn 1381-6128, 11 p.Article

Sphingosine kinase 1 is critically involved in nitric oxide-mediated human endothelial cell migration and tube formationSCHWALM, Stephanie; PFEILSCHIFTER, Josef; HUWILER, Andrea et al.British journal of pharmacology. 2010, Vol 160, Num 7, pp 1641-1651, issn 0007-1188, 11 p.Article

Heterologous desensitization of the sphingosine-1-phosphate receptors by purinoceptor activation in renal mesangial cellsCUIYAN XIN; SHUYU REN; PFEILSCHIFTER, Josef et al.British journal of pharmacology. 2004, Vol 143, Num 5, pp 581-589, issn 0007-1188, 9 p.Article

Nitric oxide and mechanisms of redox signalling: matrix and matrix-metabolizing enzymes as prime nitric oxide targetsPFEILSCHIFTER, Josef; EBERHARDT, Wolfgang; HUWILER, Andrea et al.European journal of pharmacology. 2001, Vol 429, Num 1-3, pp 279-286, issn 0014-2999Conference Paper

Redox signaling in mesangial cellsPFEILSCHIFTER, Josef; EBERHARDT, Wolfgang; BECK, Karl-Friedrich et al.Nephron. 2003, Vol 93, Num 1, pp e23-e26, issn 0028-2766Article

The immunomodulator FTY720 and its phosphorylated derivative activate the Smad signalling cascade and upregulate connective tissue growth factor and collagen type IV expression in renal mesangial cellsCUIYAN XIN; SHUYU REN; EBERHARDT, Wolfgang et al.British journal of pharmacology. 2006, Vol 147, Num 2, pp 164-174, issn 0007-1188, 11 p.Article

Hypoxia increases group IIA phospholipase A₂ expression under inflammatory conditions in rat renal mesangial cellsPETRY, Claudia; HUWILER, Andrea; EBERHARDT, Wolfgang et al.Journal of the American Society of Nephrology. 2005, Vol 16, Num 10, pp 2897-2905, issn 1046-6673, 9 p.Article

Targeting the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway to Treat Chronic Inflammatory Kidney DiseasesSCHWALM, Stephanie; PFEILSCHIFTER, Josef; HUWILER, Andrea et al.Basic & clinical pharmacology & toxicology (Print). 2014, Vol 114, Num 1, pp 44-49, issn 1742-7835, 6 p.Conference Paper

Interleukin-1 inhibits angiotensin II-stimulated protein kinase B pathway in renal mesangial cells via the inducible nitric oxide synthaseRÖLZ, Waltraud; CUIYAN XIN; REN, Shuyu et al.European journal of pharmacology. 2002, Vol 442, Num 3, pp 195-203, issn 0014-2999Article

Interleukin-1β inhibits ATP-induced protein kinase B activation in renal mesangial cells by two different mechanisms: the involvement of nitric oxide and ceramideRÖLZ, Waltraud; CUIYAN XIN; SHUYU REN et al.British journal of pharmacology. 2003, Vol 138, Num 3, pp 461-468, issn 0007-1188, 8 p.Article

Extracellular ATP and UTP activate the protein kinase B/Akt cascade via the P2Y₂ purinoceptor in renal mesangial cellsHUWILER, Andrea; RÖLZ, Waltraud; DORSCH, Simone et al.British journal of pharmacology. 2002, Vol 136, Num 4, pp 520-529, issn 0007-1188Article

Involvement of the ABC-transporter ABCC1 and the sphingosine 1-phosphate receptor subtype S1P₃ in the cytoprotection of human fibroblasts by the glucocorticoid dexamethasoneNIEUWENHUIS, Barbara; LÜTH, Anja; CHUN, Jerold et al.Journal of molecular medicine (Berlin. Print). 2009, Vol 87, Num 6, pp 645-657, issn 0946-2716, 13 p.Article

Dual effect of ceramide on human endothelial cells: Induction of oxidative stress and transcriptional upregulation of endothelial nitric oxide synthaseHUIGE LI; JUNK, Peter; HUWILER, Andrea et al.Circulation (New York, N.Y.). 2002, Vol 106, Num 17, pp 2250-2256, issn 0009-7322, 7 p.Article

Transforming growth factor-β2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-β2 by impeding CTGF expressionSHUYU REN; BABELOVA, Andrea; MORETH, Kristin et al.Kidney international. 2009, Vol 76, Num 8, pp 857-867, issn 0085-2538, 11 p.Article

Loss of sphingosine kinase-1 in carcinoma cells increases formation of reactive oxygen species and sensitivity to doxorubicin-induced DNA damageHUWILER, Andrea; KOTELEVETS, Nataliya; CUIYAN XIN et al.British journal of pharmacology. 2011, Vol 162, Num 2, pp 532-543, issn 0007-1188, 12 p.Article

De nouo ceramide biosynthesis is associated with resveratrol-induced inhibition of ornithine decarboxylase activityULRICH, Sandra; HUWILER, Andrea; LOITSCH, Stefan et al.Biochemical pharmacology. 2007, Vol 74, Num 2, pp 281-289, issn 0006-2952, 9 p.Article

Cis-4-methylsphingosine is a sphingosine-1-phosphate receptor modulatorTER BRAAK, Michael; CLAAS, Ralf Frederik; HEGEN, Bianca et al.Biochemical pharmacology. 2011, Vol 81, Num 5, pp 617-625, issn 0006-2952, 9 p.Article

SphK1 Regulates Proinflammatory Responses Associated with Endotoxin and Polymicrobial SepsisPUNEET, Padmam; YAP, Celestial T; LINGKAI WONG et al.Science (Washington, D.C.). 2010, Vol 328, Num 5983, pp 1290-1294, issn 0036-8075, 5 p.Article

Cross-talk between nitric oxide and superoxide determines ceramide formation and apoptosis in glomerular cellsPAUTZ, Andrea; FRANZEN, Rochus; DORSCH, Simone et al.Kidney international. 2002, Vol 61, Num 3, pp 790-796, issn 0085-2538Conference Paper

Changing gears in the course of glomerulonephritis by shifting superoxide to nitric oxide-dominated chemistryPFEILSCHIFTER, Josef; BECK, Karl-Friedrich; EBERHARDT, Wolfgang et al.Kidney international. 2002, Vol 61, Num 3, pp 809-815, issn 0085-2538Conference Paper

The ω3-polyunsaturated fatty acid derivatives AVX001 and AVX002 directly inhibit cytosolic phospholipase A₂ and suppress PGE₂ formation in mesangial cellsHUWILER, Andrea; FEUERHERM, Astrid J; SAKEM, Benjamin et al.British journal of pharmacology. 2012, Vol 167, Num 8, pp 1691-1701, issn 0007-1188, 11 p.Article

Glucocorticoids protect renal mesangial cells from apoptosis by increasing cellular sphingosine-1-phosphateFÖRSTER, Ankathrin; EMMLER, Tanja; SCHWALM, Stephanie et al.Kidney international. 2010, Vol 77, Num 10, pp 870-879, issn 0085-2538, 10 p.Article

Effects of high glucose on cytokine-induced nerve growth factor (NGF) expression in rat renal mesangial cellsHEESE, Klaus; BECK, Karl-Friedrich; BEHRENS, Meik Helmut et al.Biochemical pharmacology. 2003, Vol 65, Num 2, pp 293-301, issn 0006-2952, 9 p.Article