Reactivity to object and spatial novelty is normal in older Ts65Dn mice that model Down syndrome and Alzheimer's diseaseHYDE, Lynn A; CRNIC, Linda S.Brain research. 2002, Vol 945, Num 1, pp 26-30, issn 0006-8993Article

Age-related deficits in context discrimination learning in Ts65Dn mice that model Down syndrome and Alzheimer's diseaseHYDE, Lynn A; CRNIC, Linda S.Behavioral neuroscience. 2001, Vol 115, Num 6, pp 1239-1246, issn 0735-7044Article

Ts65Dn mice, a model for Down syndrome, have deficits in context discrimination learning suggesting impaired hippocampal functionHYDE, Lynn A; FRISONE, Deborah F; CRNIC, Linda S et al.Behavioural brain research. 2001, Vol 118, Num 1, pp 53-60, issn 0166-4328Article

Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active γ-secretase inhibitorsMCBRIAR, Mark D; CLADER, John W; LIXIN SONG et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 1, pp 215-219, issn 0960-894X, 5 p.Article

In two species, females exhibit superior working memory and inferior reference memory on the water radial-arm mazeBIMONTE, Heather A; HYDE, Lynn A; HOPLIGHT, Blair J et al.Physiology & behavior. 2000, Vol 70, Num 3-4, pp 311-317, issn 0031-9384Article

Characterization of the selective mGluR1 antagonist, JNJ16259685, in rodent models of movement and coordinationHODGSON, Robert A; HYDE, Lynn A; GUTHRIE, Donald H et al.Pharmacology, biochemistry and behavior. 2011, Vol 98, Num 2, pp 181-187, issn 0091-3057, 7 p.Article

Novel orally active morpholine N-arylsulfonamides y-secretase inhibitors with low CYP 3A4 liabilityJOSIEN, Hubert; BARA, Thomas; LILI ZHANG et al.Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 21, pp 6032-6037, issn 0960-894X, 6 p.Article

Differential learning strategies in spatial and nonspatial versions of the Morris water maze in the C57BL/6J inbred mouse strainSTAVNEZER, Amy Jo; HYDE, Lynn A; BIMONTE, Heather A et al.Behavioural brain research. 2002, Vol 133, Num 2, pp 261-270, issn 0166-4328Article

Age-progressing cognitive impairments and neuropathology in transgenic CRND8 miceHYDE, Lynn A; KAZDOBA, Tatiana M; HIGGINS, Guy A et al.Behavioural brain research. 2005, Vol 160, Num 2, pp 344-355, issn 0166-4328, 12 p.Article

Effects of neocortical ectopias and environmental enrichment on Hebb-Williams maze learning in BXSB miceHOPLIGHT, Blair J; SHERMAN, Gordon F; HYDE, Lynn A et al.Neurobiology of learning and memory (Print). 2001, Vol 76, Num 1, pp 33-45, issn 1074-7427Article

The effects of neocortical ectopias on Lashley III water maze learning in New Zealand Black miceHYDE, Lynn A; SHERMAN, Gordon F; STAVNEZER, Amy Jo et al.Brain research. 2000, Vol 887, Num 2, pp 482-483, issn 0006-8993Article

Estrogen restores cognition and cholinergic phenotype in an animal model of Down syndromeGRANHOLM, Ann-Charlotte E; FORD, Kerstin A; HYDE, Lynn A et al.Physiology & behavior. 2002, Vol 77, Num 2-3, pp 371-385, issn 0031-9384, 15 p.Article

Spatial and nonspatial Morris maze learning: impaired behavioral flexibility in mice with ectopias located in the prefrontal cortexHYDE, Lynn A; STAVNEZER, Amy Jo; BIMONTE, Heather A et al.Behavioural brain research. 2002, Vol 133, Num 2, pp 247-259, issn 0166-4328Article

Working memory deficits in BXSB mice with neocortical ectopiasHYDE, Lynn A; SHERMAN, Gordon F; HOPLIGHT, Blair J et al.Physiology & behavior. 2000, Vol 70, Num 1-2, pp 1-5, issn 0031-9384Article

Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitorCUMMING, Jared N; SMITH, Elizabeth M; VOIGT, Johannes et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 7, pp 2444-2449, issn 0960-894X, 6 p.Article

The anxiolytic-like profile of the nociceptin receptor agonist, endo-8-[bis(2-chlorophenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1] octane-3-carboxamide (SCH 655842): Comparison of efficacy and side effects across rodent speciesLU, Sherry X; HIGGINS, Guy A; HO, Ginny D et al.European journal of pharmacology. 2011, Vol 661, Num 1-3, pp 63-71, issn 0014-2999, 9 p.Article

Discovery of γ-secretase inhibitors efficacious in a transgenic animal model of Alzheimer's diseaseASBEROM, Theodros; ZHIQIANG ZHAO; PARKER, Eric M et al.Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 2, pp 511-516, issn 0960-894X, 6 p.Article

Small conformationally restricted piperidine N-arylsulfonamides as orally active γ-secretase inhibitorsJOSIEN, Hubert; BARA, Thomas; PISSARNITSKI, Dmitri A et al.Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 19, pp 5330-5335, issn 0960-894X, 6 p.Article

Increased seizure threshold and severity in young transgenic CRND8 miceDEL VECCHIO, Robert A; GOLD, Lisa H; NOVICK, Steve J et al.Neuroscience letters. 2004, Vol 367, Num 2, pp 164-167, issn 0304-3940, 4 p.Article

Increased auditory startle response and reduced prepulse inhibition of startle in transgenic mice expressing a double mutant form of amyloid precursor proteinMCCOOL, Martha F; VARTY, Geoffrey B; DEL VECCHIO, Robert A et al.Brain research. 2003, Vol 994, Num 1, pp 99-106, issn 0006-8993, 8 p.Article