Translating pharmacogenetics and pharmacogenomics into drug development for clinical pediatrics and beyondLEEDER, J. Steven.Drug discovery today. 2004, Vol 9, Num 13, pp 567-573, issn 1359-6446, 7 p.Article

Ontogeny of drug-metabolizing enzymes and its influence on the pathogenesis of adverse Drug reactions in children : Adverse Drug Events and Adverse Drug Reactions in Pediatric Patients: Part IVLEEDER, J. Steven.Current therapeutic research. 2001, Vol 62, Num 12, pp 900-912, issn 0011-393XConference Paper

Information theory-based analysis of CYP2C19, CYP2D6 and CYP3A5 splicing mutationsROGAN, Peter K; SVOJANOVSKY, Stan; LEEDER, J. Steven et al.Pharmacogenetics (London). 2003, Vol 13, Num 4, pp 207-218, issn 0960-314X, 12 p.Article

Impact of the CYP2C19*17 Allele on the Pharmacokinetics of Omeprazole and Pantoprazole in Children: Evidence for a Differential EffectKEARNS, Gregory L; LEEDER, J. Steven; GAEDIGK, Andrea et al.Drug metabolism and disposition. 2010, Vol 38, Num 6, pp 894-897, issn 0090-9556, 4 p.Article

UGT2B17 and SULT1A1 gene copy number variation (CNV) detection by LabChip microfluidic technologyGAEDIGK, Andrea; GAEDIGK, Roger; LEEDER, J. Steven et al.Clinical chemistry and laboratory medicine. 2010, Vol 48, Num 5, pp 627-633, issn 1434-6621, 7 p.Article

Nuclear receptor expression in fetal and pediatric liver : Correlation with CYP3A expressionVYHLIDAL, Carrie A; GAEDIGK, Roger; LEEDER, J. Steven et al.Drug metabolism and disposition. 2006, Vol 34, Num 1, pp 131-137, issn 0090-9556, 7 p.Article

Pharmacogenetics and pharmacogenomicsLEEDER, J. Steven.The Pediatric clinics of North America. 2001, Vol 48, Num 3, issn 0031-3955, x,765-781 [18 p.]Article

Biotransformation of fluticasone : In vitro characterizationPEARCE, Robin E; LEEDER, J. Steven; KEARNS, Gregory L et al.Drug metabolism and disposition. 2006, Vol 34, Num 6, pp 1035-1040, issn 0090-9556, 6 p.Article

Pathways of carbamazepine bioactivation in vitro. I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolitesPEARCE, Robin E; VAKKALAGADDA, Gangadhara R; LEEDER, J. Steven et al.Drug metabolism and disposition. 2002, Vol 30, Num 11, pp 1170-1179, issn 0090-9556, 10 p.Article

Pathways of carbamazepine bioactivation in vitro : II. The role of human cytochrome p450 enzymes in the formation of 2-hydroxyiminostilbenePEARCE, Robin E; UETRECHT, Jack P; LEEDER, J. Steven et al.Drug metabolism and disposition. 2005, Vol 33, Num 12, pp 1819-1826, issn 0090-9556, 8 p.Article

Cytochrome P4502C9 (CYP2C9) allele frequencies in canadian Native Indian and Inuit populationsGAEDIGK, Andrea; CASLEY, William L; TYNDALE, Rachel F et al.Canadian journal of physiology and pharmacology. 2001, Vol 79, Num 10, pp 841-847, issn 0008-4212Article

Selective Toll-Like Receptor Expression in Human Fetal LungPETRIKIN, Joshua E; GAEDIGK, Roger; LEEDER, J. Steven et al.Pediatric research. 2010, Vol 68, Num 4, pp 335-338, issn 0031-3998, 4 p.Article

CYP2D6*36 gene arrangements within the CYP2D6 locus : Association of CYP2D6*36 with poor metabolizer statusGAEDIGK, Andrea; BRADFORD, L. Dianne; ALANDER, Sarah W et al.Drug metabolism and disposition. 2006, Vol 34, Num 4, pp 563-569, issn 0090-9556, 7 p.Article

Developmental variations in metabolic capacity of flavin-containing mono-oxygenase 3 in childhoodSHIMIZU, Makiko; DENTON, Travis; KOZONO, Marie et al.British journal of clinical pharmacology. 2011, Vol 71, Num 4, pp 585-591, issn 0306-5251, 7 p.Article

CYP2D6 poor metabolizer status can be ruled out by a single genotyping assay for the -1584G promoter polymorphismGAEDIGK, Andrea; RYDER, Darren L; BRADFORD, L. Dianne et al.Clinical chemistry (Baltimore, Md.). 2003, Vol 49, Num 6, pp 1008-1011, issn 0009-9147, 4 p., 1Article

Unique CYP2D6 activity distribution and genotype-phenotype discordance in black AmericansGAEDIGK, Andrea; BRADFORD, L. Dianne; MARCUCCI, Kenda A et al.Clinical pharmacology and therapeutics. 2002, Vol 72, Num 1, pp 76-89, issn 0009-9236Article

Cytochrome P450 involvement in the biotransformation of cisapride and racemic norcisapride in vitro: Differential activity of individual human CYP3A isoformsPEARCE, Robin E; GOTSCHALL, R. Russell; KEARNS, Gregory L et al.Drug metabolism and disposition. 2001, Vol 29, Num 12, pp 1548-1554, issn 0090-9556Article

Transcriptomic Analysis of Human Lung DevelopmentKHO, Alvin T; BHATTACHARYA, Soumyaroop; TANTISIRA, Kelan G et al.American journal of respiratory and critical care medicine. 2010, Vol 181, Num 1, pp 54-63, issn 1073-449X, 10 p.Article

The Effect of Genotype on Methotrexate Polyglutamate Variability in Juvenile Idiopathic Arthritis and Association With Drug ResponseBECKER, Mara L; GAEDIGK, Roger; VAN HAANDEL, Leon et al.Arthritis and rheumatism. 2011, Vol 63, Num 1, pp 276-285, issn 0004-3591, 10 p.Article

CYP3A4-Mediated Carbamazepine (CBZ) Metabolism : Formation of a Covalent CBZ-CYP3A4 Adduct and Alteration of the Enzyme Kinetic ProfilePING KANG; MINGXIANG LIAO; WESTER, Michael R et al.Drug metabolism and disposition. 2008, Vol 36, Num 3, pp 490-499, issn 0090-9556, 10 p.Article

Cytochrome p4502d6 (CYP2D6) gene locus heterogeneity : Characterization of gene duplication eventsGAEDIGK, A; NDJOUNTCHE, L; RIGGS, K. Wayne et al.Clinical pharmacology and therapeutics. 2007, Vol 81, Num 2, pp 242-251, issn 0009-9236, 10 p.Article

Effect of diet on the development of drug metabolism by cytochrome P-450 enzymes in healthy infantsBLAKE, Michael J; ABDEL-RAHMAN, Susan M; PEARCE, Robin E et al.Pediatric research. 2006, Vol 60, Num 6, pp 717-723, issn 0031-3998, 7 p.Article

Pathways of Carbamazepine Bioactivation in Vitro. III. The Role of Human Cytochrome P450 Enzymes in the Formation of 2,3-DihydroxycarbamazepinePEARCE, Robin E; WEI LU; YONGQIANG WANG et al.Drug metabolism and disposition. 2008, Vol 36, Num 8, pp 1637-1649, issn 0090-9556, 13 p.Article

Characterization of cytochrome P450 2D6.1 (CYP2D6.1), CYP2D6.2, and CYP2D6.17 activities toward model CYP2D6 substrates dextromethorphan, bufuralol, and debrisoquineMARCUCCI, Kenda A; PEARCE, Robin E; CRESPI, Charles et al.Drug metabolism and disposition. 2002, Vol 30, Num 5, pp 595-601, issn 0090-9556Article

PharmGKB summary: carbamazepine pathwayTHORN, Caroline F; LECKBAND, Susan G; KELSOE, John et al.Pharmacogenetics and genomics (Print). 2011, Vol 21, Num 12, pp 906-910, issn 1744-6872, 5 p.Article