Endogenous Nitric Oxide Synthase Inhibitors in the Biology of Disease: Markers, Mediators, and Regulators?CAPLIN, Ben; LEIPER, James.Arteriosclerosis, thrombosis, and vascular biology. 2012, Vol 32, Num 6, pp 1343-1353, issn 1079-5642, 11 p.Article

Cardiovascular biology of the asymmetric dimethylarginine: Dimethylarginine dimethylaminohydrolase pathwayVALLANCE, Patrick; LEIPER, James.Arteriosclerosis, thrombosis, and vascular biology. 2004, Vol 24, Num 6, pp 1023-1030, issn 1079-5642, 8 p.Article

Over-expression of GTP-cyclohydrolase 1 feedback regulatory protein attenuates LPS and cytokine-stimulated nitric oxide productionNANDI, Manasi; KELLY, Peter; VALLANCE, Patrick et al.Vascular medicine (London). 2008, Vol 13, Num 1, pp 29-36, issn 1358-863X, 8 p.Article

Alanine-Glyoxylate Aminotransferase-2 Metabolizes Endogenous Methylarginines, Regulates NO, and Controls Blood PressureCAPLIN, Ben; ZHEN WANG; SLAVIERO, Anna et al.Arteriosclerosis, thrombosis, and vascular biology. 2012, Vol 32, Num 12, pp 2892-2900, issn 1079-5642, 9 p.Article

The ADMA/DDAH Pathway Regulates VEGF-Mediated AngiogenesisFIEDLER, Lorna R; BACHETTI, Tiziana; LEIPER, James et al.Arteriosclerosis, thrombosis, and vascular biology. 2009, Vol 29, Num 12, pp 2117-2124, issn 1079-5642, 8 p.Article

Increasing dimethylarginine levels are associated with adverse clinical outcome in severe alcoholic hepatitisMOOKERJEE, Rajeshwar P; MALAKI, Mohammed; JALAN, Rajiv et al.Hepatology (Baltimore, Md.). 2007, Vol 45, Num 1, pp 62-71, issn 0270-9139, 10 p.Article

Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolaseACHAN, Vinod; BROADHEAD, Michael; MALAKI, Mohammed et al.Arteriosclerosis, thrombosis, and vascular biology. 2003, Vol 23, Num 8, pp 1455-1459, issn 1079-5642, 5 p.Article

Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation studyLIBRI, Vincenzo; YANDIM, Cihangir; LEIPER, James et al.Lancet (British edition). 2014, Vol 384, Num 9942, pp 504-513, issn 0140-6736, 10 p.Article

Adenoviral-mediated overexpression of DDAH improves vascular tone regulationTORONDEL, Belen; NANDI, Manasi; KELLY, Peter et al.Vascular medicine (London). 2010, Vol 15, Num 3, pp 205-213, issn 1358-863X, 9 p.Article

Developmental regulation of GTP-CH1 in the porcine lung and its relationship to pulmonary vascular relaxationNANDI, Manasi; LEIPER, James; ARRIGONI, Francesca et al.Pediatric research. 2006, Vol 59, Num 6, pp 767-772, issn 0031-3998, 6 p.Article

Endogenous production of nitric oxide synthase inhibitorsANTHONY, Shelagh; LEIPER, James; VALLANCE, Patrick et al.Vascular medicine (London). 2005, Vol 10, pp S3-S9, issn 1358-863X, SUP1Conference Paper

Genetic and Pharmacological Inhibition of Dimethylarginine Dimethylaminohydrolase 1 Is Protective in Endotoxic ShockNANDI, Manasi; KELLY, Peter; TORONDEL, Belen et al.Arteriosclerosis, thrombosis, and vascular biology. 2012, Vol 32, Num 11, pp 2589-2597, issn 1079-5642, 9 p.Article

Regulation of the ADMA-DDAH system in endothelial cells: a novel mechanism for the sterol response element binding proteins, SREBP1c and -2IVASHCHENKO, Christine Y; BRADLEY, Benjamin T; ZHAOHUI AO et al.American journal of physiology. Heart and circulatory physiology. 2010, Vol 67, Num 1, issn 0363-6135, H251-H258Article

Expression of N^G,N^G-Dimethylarginine Dimethylaminohydrolase and Protein Arginine N-Methyltransferase Isoforms in Diabetic Rat Kidney : Effects of Angiotensin II Receptor BlockersONOZATO, Maristela L; TOJO, Akihiro; LEIPER, James et al.Diabetes (New York, NY). 2008, Vol 57, Num 1, pp 172-180, issn 0012-1797, 9 p.Article

Analysis of methylarginine metabolism in the cardiovascular system identifies the lung as a major source of ADMABULAU, Patrick; ZAKRZEWICZ, Dariusz; KITOWSKA, Kamila et al.American journal of physiology. Lung cellular and molecular physiology. 2007, Vol 36, Num 1, issn 1040-0605, L18-L24Article

Unexpected Effect of Proton Pump Inhibitors Elevation of the Cardiovascular Risk Factor Asymmetric DimethylarginineGHEBREMARIAM, Yohannes T; LEPENDU, Paea; LEE, Jerry C et al.Circulation (New York, N.Y.). 2013, Vol 128, Num 8, pp 845-853, issn 0009-7322, 9 p.Article

cAMP Phosphodiesterase Inhibitors Increases Nitric Oxide Production by Modulating Dimethylarginine DimethylaminohydrolasesPULLAMSETTI, Soni Savai; SAVAI, Rajkumar; SEEGER, Werner et al.Circulation (New York, N.Y.). 2011, Vol 123, Num 11, pp 1194-1204, issn 0009-7322, 11 p.Article

Isoform-specific regulation by N^G,N^G-dimethylarginine dimethylaminohydrolase of rat serum asymmetric dimethylarginine and vascular endothelium-derived relaxing factor/NODAN WANG; GILL, Pritmohinder S; VALLANCE, Patrick et al.Circulation research. 2007, Vol 101, Num 6, pp 627-635, issn 0009-7330, 9 p.Article

Metabolism of asymmetric dimethylarginines is regulated in the lung developmentally and with pulmonary hypertension induced by hypobaric hypoxiaARRIGONI, Francesca I; VALLANCE, Patrick; HAWORTH, Sheila G et al.Circulation (New York, N.Y.). 2003, Vol 107, Num 8, pp 1195-1201, issn 0009-7322, 7 p.Article

Chromosomal localization, gene structure, and expression pattern of DDAH1: Comparison with DDAH2 and implications for evolutionary originsTRAN, Cam T. L; FOX, Margaret F; VALLANCE, Patrick et al.Genomics (San Diego, Calif.). 2000, Vol 68, Num 1, pp 101-105, issn 0888-7543Article

Active site mutant dimethylarginine dimethylaminohydrolase 1 expression confers an intermediate tumour phenotype in C6 gliomasBOULT, Jessica K. R; WALKER-SAMUEL, Simon; JAMIN, Yann et al.Journal of pathology (Print). 2011, Vol 225, Num 3, pp 344-352, issn 0022-3417, 9 p.Article

Selective substrate-based inhibitors of mammalian dimethylarginine dimethylaminohydrolaseROSSITER, Sharon; SMITH, Caroline L; MALAKI, Mohammed et al.Journal of medicinal chemistry (Print). 2005, Vol 48, Num 14, pp 4670-4678, issn 0022-2623, 9 p.Article

Evidence for dysregulation of dimethylarginine dimethylaminohydrolase I in chronic hypoxia-induced pulmonary hypertensionMILLATT, Lesley J; WHITLEY, Guy Stj; LI, Dechun et al.Circulation (New York, N.Y.). 2003, Vol 108, Num 12, pp 1493-1498, issn 0009-7322, 6 p.Article

all-trans-retinoic acid increases nitric oxide synthesis by endothelial cells: A role for the induction of dimethylarginine dimethylaminohydrolaseACHAN, Vinod; TRAN, Cam T. L; ARRIGONI, Francesca et al.Circulation research. 2002, Vol 90, Num 7, pp 764-769, issn 0009-7330Article

Discovery of inhibitors of the pentein superfamily protein dimethylarginine dimethylaminohydrolase (DDAH), by virtual screening and hit analysisHARTZOULAKIS, Basil; ROSSITER, Sharon; SELWOOD, David L et al.Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 14, pp 3953-3956, issn 0960-894X, 4 p.Article