Apixaban, an oral direct factor Xa inhibitor, inhibits human clot-bound factor Xa activity in vitroXIAOSUI JIANG; CRAIN, Earl J; LUETTGEN, Joseph M et al.Thrombosis and haemostasis. 2009, Vol 101, Num 4, pp 780-782, issn 0340-6245, 3 p.Article

Inhibition of Factor XIa as a New Approach to AnticoagulationSCHUMACHER, William A; LUETTGEN, Joseph M; QUAN, Mimi L et al.Arteriosclerosis, thrombosis, and vascular biology. 2010, Vol 30, Num 3, pp 388-392, issn 1079-5642, 5 p.Article

Preparation of 1-(4-methoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective and bioavailable inhibitors of coagulation factor XaFEVIG, John M; CACCIOLA, Joseph; BURIAK, Joseph et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 14, pp 3755-3760, issn 0960-894X, 6 p.Article

Achieving structural diversity using the perpendicular conformation of alpha-substituted phenylcyclopropanes to mimic the bioactive conformation of ortho-substituted biphenyl P4 moieties : Discovery of novel, highly potent inhibitors of Factor XaQIAO, Jennifer X; CHENEY, Daniel L; LAM, Patrick Y. S et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 14, pp 4118-4123, issn 0960-894X, 6 p.Article

1-[3-Aminobenzisoxazol-5'-yl]-3-trifluoromethyl-6-[2'-(3-(R)-hydroxy-N-pyrrolidinyl)methyl-[1,1']-biphen-4-yl]-1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-one (BMS-740808) a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor XaPINTO, Donald J. P; ORWAT, Michael J; ROSSI, Karen A et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 15, pp 4141-4147, issn 0960-894X, 7 p.Article

Structure-based design of novel guanidine/benzamidine mimics: Potent and orally bioavailable factor Xa inhibitors as novel anticoagulantsLAM, Patrick Y. S; CLARK, Charles G; ROSSI, Karen A et al.Journal of medicinal chemistry (Print). 2003, Vol 46, Num 21, pp 4405-4418, issn 0022-2623, 14 p.Article

Nonbenzamidine isoxazoline derivatives as factor Xa inhibitorsQUAN, Mimi L; ELLIS, Christopher D; WEXLER, Ruth R et al.Bioorganic & medicinal chemistry letters (Print). 2003, Vol 13, Num 6, pp 1023-1028, issn 0960-894X, 6 p.Article

Structure-activity relationships of anthranilamide-based factor Xa inhibitors containing piperidinone and pyridinone P4 moietiesCORTE, James R; TIANAN FANG; RENDINA, Alan R et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 9, pp 2845-2849, issn 0960-894X, 5 p.Article

Sulfonamidolactam inhibitors of coagulation factor XaSMALLHEER, Joanne M; SHUAIGE WANG; KNABB, Robert M et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 7, pp 2428-2433, issn 0960-894X, 6 p.Article

Discovery of potent, efficacious, and orally bioavailable inhibitors of blood coagulation factor Xa with neutral P1 moietiesPINTO, Donald J. P; GALEMMO, Robert A; SMALLWOOD, Angela et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 21, pp 5584-5589, issn 0960-894X, 6 p.Article

5-Amidinobenzo[b]thiophenes as dual inhibitors of factors IXa and XaQIAO, Jennifer X; XUHONG CHENG; MODI, Dilip P et al.Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 1, pp 29-35, issn 0960-894X, 7 p.Article

Discovery of 3-amino-4-chlorophenyl P1 as a novel and potent benzamidine mimic via solid-phase synthesis of an isoxazoline libraryLAM, Patrick Y. S; ADAMS, Jessica J; CLARK, Charles G et al.Bioorganic & medicinal chemistry letters (Print). 2003, Vol 13, Num 10, pp 1795-1799, issn 0960-894X, 5 p.Article

Discovery of 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]- 3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor XaPINTO, Donald J. P; ORWAT, Michael J; LUETTGEN, Joseph M et al.Journal of medicinal chemistry (Print). 2001, Vol 44, Num 4, pp 566-578, issn 0022-2623Article

BMS-593214, an active site-directed factor Vlla inhibitor: Enzyme kinetics, antithrombotic and antihaemostatic studiesWONG, Pancras C; LUETTGEN, Joseph M; RENDINA, Alan R et al.Thrombosis and haemostasis. 2010, Vol 104, Num 2, pp 261-269, issn 0340-6245, 9 p.Article

Sulfation of Ο-Demethyl Apixaban : Enzyme Identification and Species ComparisonLIFEI WANG; RAGHAVAN, Nirmala; KAN HE et al.Drug metabolism and disposition. 2009, Vol 37, Num 4, pp 802-808, issn 0090-9556, 7 p.Article

Pyrazole-based factor Xa inhibitors containing N-arylpiperidinyl P4 residuesQIAO, Jennifer X; XUHONG CHENG; KNABB, Robert M et al.Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 5, pp 1432-1437, issn 0960-894X, 6 p.Article

Enantiopure five-membered cyclicdiamine derivatives as potent and selective inhibitors of factor Xa. Improving in vitro metabolic stability via core modificationsQIAO, Jennifer X; WANG, Tammy C; LAM, Patrick Y. S et al.Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 18, pp 5041-5048, issn 0960-894X, 8 p.Article

Inhibition of factor Xa reduces ischemic brain damage after thromboembolic stroke in ratsXINKANG WANG; LIN XU; BERNARD, Roberta et al.Stroke (1970). 2003, Vol 34, Num 2, pp 468-474, issn 0039-2499, 7 p.Article

Design, synthesis, and biological evaluation of potent and selective amidino bicyclic factor Xa inhibitorsQI HAN; DOMINGUEZ, Celia; WRIGHT, Matthew M et al.Journal of medicinal chemistry (Print). 2000, Vol 43, Num 23, pp 4398-4415, issn 0022-2623Article

Highly efficacious factor Xa inhibitors containing α-substituted phenylcycloalkyl P4 moietiesQIAO, Jennifer X; KING, Sarah R; KAN HE et al.Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 2, pp 462-468, issn 0960-894X, 7 p.Article

N-in-1 Dosing Pharmacokinetics in Drug Discovery : Experience, Theoretical and Practical ConsiderationsKAN HE; MINGXIN QIAN; HANG ZENG et al.Journal of pharmaceutical sciences. 2008, Vol 97, Num 7, pp 2568-2580, issn 0022-3549, 13 p.Article

Design, structure-activity relationship, and pharmacokinetic profile of pyrazole-based indoline factor Xa inhibitorsVARNES, Jeffrey G; WACKER, Dean A; KAN HE et al.Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 23, pp 6481-6488, issn 0960-894X, 8 p.Article

Discovery of 1 -(4 -methoxyphenyl ) -7 -oxo -6 -(4 -(2 -oxopiperidin -1 -yl )phenyl ) -4,5,6,7 -tetrahydro-1H -pyrazolo [3,4 -C]pyridine -3 -carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor xaPINTO, Donald J. P; ORWAT, Michael J; KAN HE et al.Journal of medicinal chemistry (Print). 2007, Vol 50, Num 22, pp 5339-5356, issn 0022-2623, 18 p.Article

Preparation of 1-(3-aminobenzo[d]isoxazol-5-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective, and efficacious inhibitors of coagulation factor XaLI, Yun-Long; FEVIG, John M; WEXLER, Ruth R et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 19, pp 5176-5182, issn 0960-894X, 7 p.Article

SAR and factor IXa crystal structure of a dual inhibitor of factors IXa and XaSMALLHEER, Joanne M; ALEXANDER, Richard S; KNABB, Robert M et al.Bioorganic & medicinal chemistry letters (Print). 2004, Vol 14, Num 21, pp 5263-5267, issn 0960-894X, 5 p.Article