Characterization of intrathecally administered hemokinin-1-induced nociceptive behaviors in miceWATANABE, Chizuko; MIZOGUCHI, Hirokazu; YONEZAWA, Akihiko et al.Peptides (New York, NY. 1980). 2010, Vol 31, Num 8, pp 1613-1616, issn 0196-9781, 4 p.Article

Partial agonistic action of endomorphins in the mouse spinal cordMIZOGUCHI, Hirokazu; WU, Hsiang-En; NARITA, Minoru et al.Neuroscience letters. 2001, Vol 310, Num 1, pp 66-68, issn 0304-3940Article

Dermorphin tetrapeptide analogs as potent and long-lasting analgesics with pharmacological profiles distinct from morphineMIZOGUCHI, Hirokazu; BAGETTA, Giacinto; SAKURADA, Tsukasa et al.Peptides (New York, NY. 1980). 2011, Vol 32, Num 2, pp 421-427, issn 0196-9781, 7 p.Article

Acute antinociceptive tolerance and unidirectional cross-tolerance to endomorphin-1 and endomorphin-2 given intraventricularly in the ratHUNG, Kuei-Chun; WU, Hsiang-En; MIZOGUCHI, Hirokazu et al.European journal of pharmacology. 2002, Vol 448, Num 2-3, pp 169-174, issn 0014-2999Article

Partial involvement of NMDA receptors and glial cells in the nociceptive behaviors induced by intrathecally administered histamineMIZOGUCHI, Hirokazu; KOMATSU, Takaaki; SAKURADA, Shinobu et al.Neuroscience letters. 2011, Vol 495, Num 2, pp 83-87, issn 0304-3940, 5 p.Article

Possible involvement of dynorphin A release via μ₁-opioid receptor on supraspinal antinociception of endomorphin-2SAKURADA, Shinobu; SAWAI, Toshiki; MIZOGUCHI, Hirokazu et al.Peptides (New York, NY. 1980). 2008, Vol 29, Num 9, pp 1554-1560, issn 0196-9781, 7 p.Article

Lack of a rewarding effect and a locomotor-enhancing effect of the selective μ-opioid receptor agonist amidino-TAPAMIZOGUCHI, Hirokazu; WATANABE, Chizuko; SAKURADA, Shinobu et al.Psychopharmacologia. 2010, Vol 212, Num 2, pp 215-225, issn 0033-3158, 11 p.Article

Differential involvement of μ₁-opioid receptors in dermorphin tetrapeptide analogues-induced antinociceptionMIZOGUCHI, Hirokazu; YUHKI, Masayuki; WATANABE, Hiroyuki et al.European journal of pharmacology. 2004, Vol 486, Num 1, pp 19-24, issn 0014-2999, 6 p.Article

Loss of μ-opioid receptor-mediated G-protein activation in the pons/medulla of mice lacking the exons 2 and 3 of μ-opioid receptor geneMIZOGUCHI, Hirokazu; WU, Hsiang-En; NARITA, Minoru et al.Neuroscience letters. 2002, Vol 335, Num 2, pp 91-94, issn 0304-3940, 4 p.Article

Involvement of glial cells in the nociceptive behaviors induced by a high-dose of histamine administered intrathecallyMIZOGUCHI, Hirokazu; KOMATSU, Takaaki; SAKURADA, Shinobu et al.European journal of pharmacology. 2011, Vol 653, Num 1-3, pp 21-25, issn 0014-2999, 5 p.Article

Contribution of spinal μ₁-opioid receptors and dynorphin B to the antinociception induced by Tyr-D-Arg-Phe-SarMIZOGUCHI, Hirokazu; ITO, Kanenori; WATANABE, Hiroyuki et al.Peptides (New York, NY. 1980). 2006, Vol 27, Num 11, pp 2786-2793, issn 0196-9781, 8 p.Article

Involvement of the histaminergic system in the nociceptin-induced pain-related behaviors in the mouse spinal cordSAKURADA, Shinobu; WATANABE, Hiroyuki; MIZOGUCHI, Hirokazu et al.Pain (Amsterdam). 2004, Vol 112, Num 1-2, pp 171-182, issn 0304-3959, 12 p.Article

Up-regulation of spinal μ-opioid receptor function to activate G-protein by chronic naloxone treatmentNARITA, Minoru; MIZOGUCHI, Hirokazu; NAGASE, Hiroshi et al.Brain research. 2001, Vol 913, Num 2, pp 170-173, issn 0006-8993Article

Intrathecal high-dose histamine induces spinally-mediated nociceptive behavioral responses through a polyamine site of NMDA receptorsWATANABE, Chizuko; ONTO, Tohru; WATANABE, Hiroyuki et al.European journal of pharmacology. 2008, Vol 581, Num 1-2, pp 54-63, issn 0014-2999, 10 p.Article

Possible involvement of endogenous nociceptin/orphanin FQ in the pain-related behavioral responses induced by its own metabolite, nociceptin/orphanin FQ(14-17)WATANABE, Hiroyuki; MIZOGUCHI, Hirokazu; ORITO, Tohru et al.Peptides (New York, NY. 1980). 2007, Vol 28, Num 3, pp 670-677, issn 0196-9781, 8 p.Article

Differential inhibitory effects of μ-opioids on substance P- and capsaicin-induced nociceptive behavior in miceWATANABE, Hiroyuki; NAKAYAMA, Daisuke; SAKURADA, Tsukasa et al.Peptides (New York, NY. 1980). 2006, Vol 27, Num 4, pp 760-768, issn 0196-9781, 9 p.Article

Rational drug design and synthesis of a selective ε opioid receptor antagonist on the basis of the accessory site conceptFUJII, Hideaki; NARITA, Minoru; MIZOGUCHI, Hirokazu et al.Bioorganic & medicinal chemistry letters (Print). 2004, Vol 14, Num 16, pp 4241-4243, issn 0960-894X, 3 p.Article

Antisera against endogenous opioids increase the nocifensive response to formalin : demonstration of inhibitory β-endorphinergic controlWU, Hsiang-En; HUNG, Kuei-Chun; OHSAWA, Masahiro et al.European journal of pharmacology. 2001, Vol 421, Num 1, pp 39-43, issn 0014-2999Article

Implications of Ca²⁺-activated Cl^- channels in the δ-opioid receptor-mediated antinociception in the mouse spinal cordYAMAZAKI, Mitsuaki; MIZOGUCHI, Hirokazu; OHSAWA, Masahiko et al.Neuroscience letters. 2000, Vol 295, Num 3, pp 113-115, issn 0304-3940Article

Involvement of spinal protein kinase C in thermal hyperalgesia evoked by partial sciatic nerve ligation, but not by inflammation in the mouseOHSAWA, Masahiro; NARITA, Minoru; MIZOGUCHI, Hirokazu et al.European journal of pharmacology. 2000, Vol 403, Num 1-2, pp 81-85, issn 0014-2999Article

Antinociceptive effects of spinally administered nociceptin/orphanin FQ and its N-terminal fragments on capsaicin-induced nociceptionKATSUYAMA, Soh; MIZOGUCHI, Hirokazu; KOMATSU, Takaaki et al.Peptides (New York, NY. 1980). 2011, Vol 32, Num 7, pp 1530-1535, issn 0196-9781, 6 p.Article

A Tyr-W-MIF-1 analog containing D-Pro² discriminates among antinociception in mice mediated by different classes of μ-opioid receptorsNAKAYAMA, Daisuke; WATANABE, Chizuko; WATANABE, Hiroyuki et al.European journal of pharmacology. 2007, Vol 563, Num 1-3, pp 109-116, issn 0014-2999, 8 p.Article

Region-dependent G-protein activation by κ-opioid receptor agonists in the mouse brainMIZOGUCHI, Hirokazu; LEITERMANN, Randy J; NARITA, Minoru et al.Neuroscience letters. 2004, Vol 356, Num 2, pp 145-147, issn 0304-3940, 3 p.Article

Involvement of β-arrestin-2 in modulation of the spinal antinociception induced by μ-opioid receptor agonists in the mouseOHSAWA, Masahiro; MIZOGUCHI, Hirokazu; NARITA, Minoru et al.Neuroscience letters. 2003, Vol 346, Num 1-2, pp 13-16, issn 0304-3940, 4 p.Article

Reduced hyperalgesia induced by nerve injury, but not by inflammation in mice lacking protein kinase Cγ isoformOHSAWA, Masahiro; NARITA, Minoru; MIZOGUCHI, Hirokazu et al.European journal of pharmacology. 2001, Vol 429, Num 1-3, pp 157-160, issn 0014-2999Conference Paper