Major determinants in hepatic disposition of polystyrene nanospheres: Implication for rational design of particulate drug carriersOGAWARA, Ken-Ichi; HIGAKI, Kazutaka; KIMURA, Toshikiro et al.Critical reviews in therapeutic drug carrier systems. 2002, Vol 19, Num 4-5, pp 277-306, issn 0743-4863, 30 p.Article

Prolongation of residence time of liposome by surface-modification with mixture of hydrophilic polymersSHEHATA, Tamer; OGAWARA, Ken-Ichi; HIGAKI, Kazutaka et al.International journal of pharmaceutics. 2008, Vol 359, Num 1-2, pp 272-279, issn 0378-5173, 8 p.Article

Casein enhances stability of peptides in intestinal lumen: Role of digested products of caseinOHTANI, Seiji; OGAWARA, Ken-Ichi; HIGAKI, Kazutaka et al.Pharmaceutical research. 2003, Vol 20, Num 11, pp 1746-1751, issn 0724-8741, 6 p.Article

Amino Acids Suppress Apoptosis Induced by Sodium Laurate, An Absorption EnhancerTAKAYAMA, Chie; MUKAIZAWA, Fuyuki; FUJITA, Takuya et al.Journal of pharmaceutical sciences. 2009, Vol 98, Num 12, pp 4629-4638, issn 0022-3549, 10 p.Article

Time-dependent changes in opsonin amount associated on nanoparticles alter their hepatic uptake characteristicsNAGAYAMA, Susumu; OGAWARA, Ken-Ichi; FUKUOKA, Yoshiko et al.International journal of pharmaceutics. 2007, Vol 342, Num 1-2, pp 215-221, issn 0378-5173, 7 p.Article

Amino acids protect epithelial cells from local toxicity by absorption enhancer, sodium laurateYATA, Takashi; ENDO, Yoko; SONE, Miki et al.Journal of pharmaceutical sciences. 2001, Vol 90, Num 10, pp 1456-1465, issn 0022-3549Article

In vivo anti-tumor effect of PEG liposomal doxorubicin (DOX) in DOX-resistant tumor-bearing mice : Involvement of cytotoxic effect on vascular endothelial cellsOGAWARA, Ken-Ichi; UN, Keita; TANAKA, Ken-Ichi et al.Journal of controlled release. 2009, Vol 133, Num 1, pp 4-10, issn 0168-3659, 7 p.Article

Evaluation of in vivo dissolution behavior and GI transit of griseofulvin, a BCS class II drugFUJIOKA, Yoshitsugu; METSUGI, Yukiko; OGAWARA, Ken-Ichi et al.International journal of pharmaceutics. 2008, Vol 352, Num 1-2, pp 36-43, issn 0378-5173, 8 p.Article

Skin permeation of propranolol from polymeric film containing terpene enhancers for transdermal useAMNUAIKIT, Chomchan; IKEUCHI, Itsue; OGAWARA, Ken-Ichi et al.International journal of pharmaceutics. 2005, Vol 289, Num 1-2, pp 167-178, issn 0378-5173, 12 p.Article

Surface hydrophobicity of particles is not necessarily the most important determinant in their in vivo disposition after intravenous administration in ratsOGAWARA, Ken-Ichi; FURUMOTO, Kentaro; TAKAKURA, Yoshinobu et al.Journal of controlled release. 2001, Vol 77, Num 3, pp 191-198, issn 0168-3659Article

PEG liposomalization of paclitaxel improved its in vivo disposition and anti-tumor efficacyYOSHIZAWA, Yuta; KONO, Yusuke; OGAWARA, Ken-Ichi et al.International journal of pharmaceutics (Print). 2011, Vol 412, Num 1-2, pp 132-141, issn 0378-5173, 10 p.Article

Estimation of intradermal disposition kinetics of drugs: II. Factors determining penetration of drugs from viable skin to muscular layerHIGAKI, Kazutaka; ASAI, Masahide; SUYAMA, Takayuki et al.International journal of pharmaceutics. 2002, Vol 239, Num 1-2, pp 129-141, issn 0378-5173Article

Quantitative Evaluation of PEPT1 Contribution to Oral Absorption of Cephalexin in RatsHIRONAKA, Takanori; ITOKAWA, Shota; OGAWARA, Ken-Ichi et al.Pharmaceutical research. 2009, Vol 26, Num 1, pp 40-50, issn 0724-8741, 11 p.Article

Appearance of Double Peaks in Plasma Concentration-time Profile after Oral Administration Depends on Gastric Emptying Profile and Weight FunctionMETSUGI, Yukiko; MIYAJI, Yoshihiro; OGAWARA, Ken-Ichi et al.Pharmaceutical research. 2008, Vol 25, Num 4, pp 886-895, issn 0724-8741, 10 p.Article

Determinants for in vivo anti-tumor effects of PEG liposomal doxorubicin: Importance of vascular permeability within tumorsOGAWARA, Ken-Ichi; UN, Keita; MINATO, Keiko et al.International journal of pharmaceutics. 2008, Vol 359, Num 1-2, pp 234-240, issn 0378-5173, 7 p.Article

Evaluation of inhibitory activity of casein on proteases in rat intestineOHTANI, Seiji; SHIRASU, Kyoko; OGAWARA, Ken-Ichi et al.Pharmaceutical research. 2003, Vol 20, Num 4, pp 611-617, issn 0724-8741, 7 p.Article

Mechanisms of cytoprotective effect of amino acids on local toxicity caused by sodium laurate, a drug absorption enhancer, in intestinal epitheliumENDO, Yoko; HANADA, Kiyonori; MIYAKE, Masateru et al.Journal of pharmaceutical sciences. 2002, Vol 91, Num 3, pp 730-743, issn 0022-3549Article

Prediction of oral absorption of griseofulvin, a BCS class II drug, based on GITA model: Utilization of a more suitable medium for in-vitro dissolution studyFUJIOKA, Yoshitsugu; KADONO, Keitaro; FUJIE, Yasuko et al.Journal of controlled release. 2007, Vol 119, Num 2, pp 222-228, issn 0168-3659, 7 p.Article

Importance of bile acids for novel oral absorption system containing polyamines to improve intestinal absorptionMIYAKE, Masateru; MINAMI, Takanori; TOGUCHI, Hajime et al.Journal of controlled release. 2006, Vol 115, Num 2, pp 130-133, issn 0168-3659, 4 p.Article

Novel oral formulation safely improving intestinal absorption of poorly absorbable drugs : Utilization of polyamines and bile acidsMIYAKE, Masateru; MINAMI, Takanori; HIROTA, Masao et al.Journal of controlled release. 2006, Vol 111, Num 1-2, pp 27-34, issn 0168-3659, 8 p.Article

Evaluation of Factors Affecting Gastrointestinal Absorption of a Novel Anticoagulant FX-93 for Development of Oral FormulationTAKEMURA, Shigeo; KONDO, Hiromu; SUZUMURA, Kenichi et al.Journal of pharmaceutical sciences. 2012, Vol 101, Num 6, pp 2134-2142, issn 0022-3549, 9 p.Article

Prediction of plasma concentration-time curve of orally administered theophylline based on a scintigraphic monitoring of gastrointestinal transit in human volunteersHARUTA, Shunji; KAWAI, Keiichi; NISHII, Ryuichi et al.International journal of pharmaceutics. 2002, Vol 233, Num 1-2, pp 179-190, issn 0378-5173Article

Novel Comb-Shaped PEG Modification Enhances the Osteoclastic Inhibitory Effect and Bone Delivery of Osteoprotegerin After Intravenous Administration in Ovariectomized RatsMIYAJI, Yoshihiro; KASUYA, Yuji; FURUTA, Yoshitake et al.Pharmaceutical research. 2012, Vol 29, Num 11, pp 3143-3155, issn 0724-8741, 13 p.Article

Effect of coupling of albumin onto surface of PEG liposome on its in vivo dispositionFURUMOTO, Kentaro; YOKOE, Jun-Ichi; OGAWARA, Ken-Ichi et al.International journal of pharmaceutics. 2007, Vol 329, Num 1-2, pp 110-116, issn 0378-5173, 7 p.Article

Pre-coating with serum albumin reduces receptor-mediated hepatic disposition of polystyrene nanosphere: implications for rational design of nanoparticlesOGAWARA, Ken-Ichi; FURUMOTO, Kentaro; NAGAYAMA, Susumu et al.Journal of controlled release. 2004, Vol 100, Num 3, pp 451-455, issn 0168-3659, 5 p.Article