Structural characterization of in vitro rat liver microsomal metabolites of antihistamine desloratadine using LTQ-Orbitrap hybrid mass spectrometer in combination with online hydrogen/deuterium exchange HR-LC/MSGUODONG CHEN; DAARO, Ibrahim; PRAMANIK, Birendra N et al.Journal of mass spectrometry. 2009, Vol 44, Num 2, pp 203-213, issn 1076-5174, 11 p.Article

SCH 206272: a potent, orally active tachykinin NK₁, NK₂, and NK₃ receptor antagonistANTHES, John C; CHAPMAN, Richard W; RIZZO, Charles et al.European journal of pharmacology. 2002, Vol 450, Num 2, pp 191-202, issn 0014-2999Article

Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor : A potential therapeutic agent for the treatment of hepatitis C infectionVENKATRAMAN, Srikanth; BOGEN, Stéphane L; WEIDONG PAN et al.Journal of medicinal chemistry (Print). 2006, Vol 49, Num 20, pp 6074-6086, issn 0022-2623, 13 p.Article

Discovery and Structure-Activity Relationship of P₁-P₃ Ketoamide Derived Macrocyclic Inhibitors of Hepatitis C Virus NS3 ProteaseVENKATRAMAN, Srikanth; VELAZQUEZ, Francisco; AGRAWAL, Sony et al.Journal of medicinal chemistry (Print). 2009, Vol 52, Num 2, pp 336-346, issn 0022-2623, 11 p.Article

Synthesis of substituted 4(Z)-(methoxyimino)pentyl-1-piperidines as dual NK₁/NK₂ inhibitorsTING, Pauline C; LEE, Joe F; ANTHES, John C et al.Bioorganic & medicinal chemistry letters (Print). 2001, Vol 11, Num 4, pp 491-494, issn 0960-894XArticle

Synthesis and NK₁/NK₂ receptor activity of substituted-4(Z)-(methoxyimino)pentyl-1-piperazinesTING, Pauline C; LEE, Joe F; ANTHES, John C et al.Bioorganic & medicinal chemistry letters (Print). 2000, Vol 10, Num 20, pp 2333-2335, issn 0960-894XArticle

Benzimidazole-substituted (3-phenoxypropyl)amines as histamine H3 receptor ligandsASLANIAN, Robert; XIAOHONG ZHU; VACCARO, Henry A et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 18, pp 5032-5036, issn 0960-894X, 5 p.Article

The design and synthesis of novel NK₁/NK₂ dual antagonistsREICHARD, Gregory A; BALL, Zachary T; ASLANIAN, Robert et al.Bioorganic & medicinal chemistry letters (Print). 2000, Vol 10, Num 20, pp 2329-2332, issn 0960-894XArticle

Synthesis and NK₁/NK₂ binding activities of a series of diacyl-substituted 2-arylpiperazinesBLYTHIN, David J; XIAO CHEN; PIWINSKI, John J et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 21, pp 3161-3165, issn 0960-894X, 5 p.Article

Structure-activity relationships of oxime neurokinin antagonists: Oxime modificationsREICHARD, Gregory A; SPITLER, James; ASLANIAN, Robert et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 5, pp 833-836, issn 0960-894XArticle

Preparation of oxime dual NK₁/NK₂ antagonists with reduced NK₃ affinityREICHARD, Gregory A; GRICE, Cheryl A; SHIH, Neng-Yang et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 17, pp 2355-2358, issn 0960-894XArticle

Synthesis and structure-activity relationships of oxime neurokinin antagonists: Discovery of potent arylamidesSHIH, Neng-Yang; ALBANESE, Margaret; WONG, Shing-Chung et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 2, pp 141-145, issn 0960-894XArticle

Triaryl bis-sulfones as a new class of cannabinoid CB2 receptor inhibitors: identification of a lead and initial SAR studiesLAVEY, Brian J; KOZLOWSKI, Joseph A; HIPKIN, R. William et al.Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 3, pp 783-786, issn 0960-894X, 4 p.Article

Identification of a novel 1'-[5-((3,5-dichlorobenzoyl)methylamino)-3-(3,4-dichlorophenyl)-4-(methoxyimino) pentyl]-2-oxo-(1,4'-bipiperidine) as a dual NK₁/NK₂ antagonistTING, Pauline C; LEE, Joe F; SHIH, Neng-Yang et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 16, pp 2125-2128, issn 0960-894XArticle

Structural determinants for histamine H₁ affinity, hERG affinity and QTc prolongation in a series of terfenadine analogsASLANIAN, Robert; PIWINSKI, John J; HEY, John A et al.Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 17, pp 5043-5047, issn 0960-894X, 5 p.Article

Identification of a dual histamine H₁/H₃ receptor ligand based on the H₁ antagonist chlorpheniramineASLANIAN, Robert; MUTAHI, Mwangi Wa; SHIH, Neng-Yang et al.Bioorganic & medicinal chemistry letters (Print). 2003, Vol 13, Num 12, pp 1959-1961, issn 0960-894X, 3 p.Article

8-Methoxyquinolines as PDE4 inhibitorsBILLAH, Motasim; BUCKLEY, George M; MINNICOZZI, Michael et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 12, pp 1617-1619, issn 0960-894XArticle

Discovery of a highly potent series of oxazole-based phosphodiesterase 4 inhibitorsKUANG, Rongze; SHUE, Ho-Jane; ASLANIAN, Robert et al.Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 18, pp 5150-5154, issn 0960-894X, 5 p.Article

Cyclic urea derivatives as potent NK₁ selective antagonistsSHUE, Ho-Jane; XIAO CHEN; PIWINSKI, John J et al.Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 17, pp 3896-3899, issn 0960-894X, 4 p.Article

Novel substituted pyrimidines as HCV replication (replicase) inhibitorsKWONG, Cecil D; CLARK, Jeremy L; SHIH, Neng-Yang et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 2, pp 1160-1164, issn 0960-894X, 5 p.Article

2-(2-Aminothiazol-4-yl)pyrrolidine-based tartrate diamides as potent, selective and orally bioavailable TACE inhibitorsCHAOYANG DAI; DANSU LI; ZHUYAN GUO et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 10, pp 3172-3176, issn 0960-894X, 5 p.Article

Cyclic urea derivatives as potent NK₁ selective aantagonists. Part II: Effects of fluoro and benzylic methyl substitutionsSHUE, Ho-Jane; XIAO CHEN; PIWINSKI, John J et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 4, pp 1065-1069, issn 0960-894X, 5 p.Article

Novel histamine H₃ receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine scaffoldVACCARO, Wayne D; SHER, Rosy; WILLIAMS, Shirley M et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 2, pp 395-399, issn 0960-894X, 5 p.Article

Discovery of oxazole-based PDE4 inhibitors with picomolar potencyRONGZE KUANG; SHUE, Ho-Jane; JIANHUA CAO et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 7, pp 2594-2597, issn 0960-894X, 4 p.Article

Identification of a novel, orally bioavailable histamine H₃receptor antagonist based on the 4-benzyl-(1H-imidazol-4-yl) templateASLANIAN, Robert; MUTAHI, Mwangi W; ROSENBLUM, Stuart B et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 6, pp 937-941, issn 0960-894XArticle