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Dermorphin tetrapeptide analogs as potent and long-lasting analgesics with pharmacological profiles distinct from morphineMIZOGUCHI, Hirokazu; BAGETTA, Giacinto; SAKURADA, Tsukasa et al.Peptides (New York, NY. 1980). 2011, Vol 32, Num 2, pp 421-427, issn 0196-9781, 7 p.Article

Syntheses and receptor-binding studies of derivatives of the opioid antagonist naltrexoneUWAI, Koji; UCHIYAMA, Hiroko; SAKURADA, Shinobu et al.Bioorganic & medicinal chemistry. 2004, Vol 12, Num 2, pp 417-421, issn 0968-0896, 5 p.Article

Effects of menatetrenone on the bone and serum levels of vitamin K2 (menaquinone derivatives) in osteopenia induced by phenytoin in growing ratsONODERA, Kenji; TAKAHASHI, Atsushi; WAKABAYASHI, Hiroyuki et al.Nutrition (Burbank, Los Angeles County, Calif.). 2003, Vol 19, Num 5, pp 446-450, issn 0899-9007, 5 p.Article

Anticonvulsant properties of the novel nootropic agent nefiracetam in seizure models of mice and ratsKITANO, Yutaka; KOMIYAMA, Chika; MAKINO, Mitsuhiro et al.Epilepsia (Copenhagen). 2005, Vol 46, Num 6, pp 811-818, issn 0013-9580, 8 p.Article

Evidence that nitric oxide-glutamate cascade modulates spinal antinociceptive effect of morphine: a behavioural and microdialysis study in ratsWATANABE, Chizuko; OKUDA, Kazuhiro; SAKURADA, Chikai et al.Brain research. 2003, Vol 990, Num 1-2, pp 77-86, issn 0006-8993, 10 p.Article

Antinociceptive effects of spinally administered nociceptin/orphanin FQ and its N-terminal fragments on capsaicin-induced nociceptionKATSUYAMA, Soh; MIZOGUCHI, Hirokazu; KOMATSU, Takaaki et al.Peptides (New York, NY. 1980). 2011, Vol 32, Num 7, pp 1530-1535, issn 0196-9781, 6 p.Article

A Tyr-W-MIF-1 analog containing D-Pro² discriminates among antinociception in mice mediated by different classes of μ-opioid receptorsNAKAYAMA, Daisuke; WATANABE, Chizuko; WATANABE, Hiroyuki et al.European journal of pharmacology. 2007, Vol 563, Num 1-3, pp 109-116, issn 0014-2999, 8 p.Article

Degradation of endomorphin-2 at the supraspinal level in mice is initiated by dipeptidyl peptidase IV: an in vitro and in vivo studySAKURADA, Chikai; SAKURADA, Shinobu; HAYASHI, Takafumi et al.Biochemical pharmacology. 2003, Vol 66, Num 4, pp 653-661, issn 0006-2952, 9 p.Article

Evidence for an involvement of peripheral serotonin in p-chloroamphetamine-induced ejaculation of ratsYONEZAWA, Akihiko; YOSHIZUMI, Masaru; EBIKO, Manabu et al.Pharmacology, biochemistry and behavior. 2005, Vol 82, Num 4, pp 744-750, issn 0091-3057, 7 p.Article

The anorectic effect of neurotensin is mediated via a histamine H₁ receptor in miceOHINATA, Kousaku; SHIMANO, Tomoko; YAMAUCHI, Rena et al.Peptides (New York, NY. 1980). 2004, Vol 25, Num 12, pp 2135-2138, issn 0196-9781, 4 p.Article

Differential effects of intraplantar capsazepine and ruthenium red on capsaicin-induced desensitization in miceSAKURADA, Tsukasa; MATSUMURA, Toshihiro; MORIYAMA, Tomoko et al.Pharmacology, biochemistry and behavior. 2003, Vol 75, Num 1, pp 115-121, issn 0091-3057, 7 p.Article

Degradation of nociceptin (orphanin FQ) by mouse spinal cord synaptic membranes is triggered by endopeptidase-24.11: an in vitro and in vivo studySAKURADA, Chikai; SAKURADA, Shinobu; ORITO, Tohru et al.Biochemical pharmacology. 2002, Vol 64, Num 8, pp 1293-1303, issn 0006-2952, 11 p.Article

Structure-activity relationships (SAR) of [D-arg²]dermorphin(1-4) analogues, N^a-amidino-Tyr-D-Arg-Phe-X¹OGAWA, Tadashi; MIYAMAE, Tetsuhisa; OKAYAMA, Toru et al.Chemical and pharmaceutical bulletin. 2002, Vol 50, Num 6, pp 771-780, issn 0009-2363Article

Synthesis and antinociceptive activity of orally active opioid peptides: Improvement of oral bioavailability by esterificationOGAWA, Tadashi; ARAKI, Mamoru; MIYAMAE, Tetsuhisa et al.Chemical and pharmaceutical bulletin. 2003, Vol 51, Num 7, pp 759-771, issn 0009-2363, 13 p.Article

The role of spinal nitric oxide and glutamate in nociceptive behaviour evoked by high-dose intrathecal morphine in ratsWATANABE, Chizuko; SAKURADA, Tsukasa; OKUDA, Kazuhiro et al.Pain (Amsterdam). 2003, Vol 106, Num 3, pp 269-283, issn 0304-3959, 15 p.Article

α₂-Adrenoceptor antagonists : effects on ejaculation, penile erection and pelvic thrusting behavior in dogsYONEZAWA, Akihiko; ANDO, Ryuichiro; WATANABE, Chizuko et al.Pharmacology, biochemistry and behavior. 2001, Vol 70, Num 1, pp 141-147, issn 0091-3057Article

Intraplantar injection of bergamot essential oil induces peripheral antinociception mediated by opioid mechanismSAKURADA, Tsukasa; MIZOGUCHI, Hirokazu; KUWAHATA, Hikari et al.Pharmacology, biochemistry and behavior. 2011, Vol 97, Num 3, pp 436-443, issn 0091-3057, 8 p.Article

Ejaculatory response induced by a 5-HT₂ receptor agonist m-CPP in rats : Differential roles of 5-HT₂ receptor subtypesYONEZAWA, Akihiko; YOSHIZUMI, Masaru; EBIKO, Manabu et al.Pharmacology, biochemistry and behavior. 2008, Vol 88, Num 4, pp 367-373, issn 0091-3057, 7 p.Article

Involvement of spinal μ₁-opioid receptors on the Tyr-D-Arg-Phe-sarcosine-induced antinociceptionMIZOGUCHI, Hirokazu; NAKAYAMA, Daisuke; WATANABE, Hiroyuki et al.European journal of pharmacology. 2006, Vol 540, Num 1-3, pp 67-72, issn 0014-2999, 6 p.Article

Up-regulation of μ-opioid receptor-mediated G-protein activation in protein kinase Cγ knockout mice following repeated naloxone treatmentNARITA, Minoru; SUZUKI, Masami; MIZOGUCHI, Hirokazu et al.Neuroscience letters. 2003, Vol 338, Num 2, pp 103-106, issn 0304-3940, 4 p.Article

Structure-antinociceptive activity studies of incarvillateine, a monoterpene alkaloid from Incarvillea sinensisNAKAMURA, Motoyuki; CHI, Yu-Ming; YAN, Wen-Mei et al.Planta medica. 2001, Vol 67, Num 2, pp 114-117, issn 0032-0943Article

Partial involvement of NMDA receptors and glial cells in the nociceptive behaviors induced by intrathecally administered histamineMIZOGUCHI, Hirokazu; KOMATSU, Takaaki; SAKURADA, Shinobu et al.Neuroscience letters. 2011, Vol 495, Num 2, pp 83-87, issn 0304-3940, 5 p.Article

Possible involvement of dynorphin A release via μ₁-opioid receptor on supraspinal antinociception of endomorphin-2SAKURADA, Shinobu; SAWAI, Toshiki; MIZOGUCHI, Hirokazu et al.Peptides (New York, NY. 1980). 2008, Vol 29, Num 9, pp 1554-1560, issn 0196-9781, 7 p.Article

Antinociceptive effect of spinally injected L-NAME on the acute nociceptive response induced by low concentrations of formalinSAKURADA, Chikai; SUGIYAMA, Akinori; NAKAYAMA, Miho et al.Neurochemistry international. 2001, Vol 38, Num 5, pp 417-423, issn 0197-0186Article