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Population pharmacokinetic modeling and model validation of a spicamycin derivative, KRN5500, in phase 1 studyTAKAMA, Hirotaka; TANAKA, Hideji; SUDO, Tomohiro et al.Cancer chemotherapy and pharmacology. 2001, Vol 47, Num 5, pp 404-410, issn 0344-5704Article

KRAS mutation confers resistance to antibody-dependent cellular cytotoxicity of cetuximab against human colorectal cancer cellsNAKADATE, Yusuke; KODERA, Yasuo; KITAMURA, Yuka et al.International journal of cancer (Print). 2014, Vol 134, Num 9, pp 2146-2155, issn 0020-7136, 10 p.Article

Phase I dose-finding and pharmacokinetic study of the oral epidermal growth factor receptor tyrosine kinase inhibitor Ro50-8231 (erlotinib) in Japanese patients with solid tumorsYAMAMOTO, Noboru; HORIIKE, Atsushi; FUJISAKA, Yasuhito et al.Cancer chemotherapy and pharmacology. 2008, Vol 61, Num 3, pp 489-496, issn 0344-5704, 8 p.Article

Antibody-dependent cellular cytotoxicity of cetuximab against tumor cells with wild-type or mutant epidermal growth factor receptorKIMURA, Hideharu; SAKAI, Kazuko; ARAO, Tokuzo et al.Cancer science. 2007, Vol 98, Num 8, pp 1275-1280, issn 1347-9032, 6 p.Article

High sensitivity detection of Epidermal growth factor receptor mutations in the pleural effusion of non-small cell lung cancer patientsKIMURA, Hideharu; FUJIWARA, Yutaka; SONE, Takashi et al.Cancer science. 2006, Vol 97, Num 7, pp 642-648, issn 1347-9032, 7 p.Article

Oncoprotein 18 overexpression increases the sensitivity to vindesine in the human lung carcinoma cellsNISHIO, Kazuto; NAKAMURA, Takashi; KOH, Yasuhiro et al.Cancer. 2001, Vol 91, Num 8, pp 1494-1499, issn 0008-543XArticle

Phase 1 and dose-finding study of patritumab (U3-1287), a human monoclonal antibody targeting HER3, in Japanese patients with advanced solid tumorsWAKUI, Hiroshi; YAMAMOTO, Noboru; NAKAMICHI, Shinji et al.Cancer chemotherapy and pharmacology. 2014, Vol 73, Num 3, pp 511-516, issn 0344-5704, 6 p.Article

Phase I and pharmacokinetic study of TSU-68, a novel multiple receptor tyrosine kinase inhibitor, by twice daily oral administration between meals in patients with advanced solid tumorsUEDA, Yutaka; SHIMOYAMA, Tatsu; MURAKAMI, Haruyasu et al.Cancer chemotherapy and pharmacology. 2011, Vol 67, Num 5, pp 1101-1109, issn 0344-5704, 9 p.Article

Anticancer effects of ZD6474, a VEGF receptor tyrosine kinase inhibitor, in gefitinib (Iressa)-sensitive and resistant xenograft modelsTAGUCHI, Fumiko; KOH, Yasuhiro; KOIZUMI, Fumiaki et al.Cancer science. 2004, Vol 95, Num 12, pp 984-989, issn 1347-9032, 6 p.Article

Phase I, pharmacokinetic, and biological studies of TSU-68, a novel multiple receptor tyrosine kinase inhibitor, administered after meals with solid tumorsMURAKAMI, Haruyasu; UEDA, Yutaka; SHIMOYAMA, Tatsu et al.Cancer chemotherapy and pharmacology. 2011, Vol 67, Num 5, pp 1119-1128, issn 0344-5704, 10 p.Article

Risk factors for skeletal-related events in patients with non-small cell lung cancer treated by chemotherapySEKINE, Ikuo; NOKIHARA, Hiroshi; YAMAMOTO, Noboru et al.Lung cancer. 2009, Vol 65, Num 2, pp 219-222, issn 0169-5002, 4 p.Article

Common arm analysis : One approach to develop the basis for global standardization in clinical trials of non-small cell lung cancerSEKINE, Ikuo; NOKIHARA, Hiroshi; YAMAMOTO, Noboru et al.Lung cancer. 2006, Vol 53, Num 2, pp 157-164, issn 0169-5002, 8 p.Article

Translational studies for target-based drugsNISHIO, Kazuto; ARAO, Tokuzo; SHIMOYAMA, Tatsu et al.Cancer chemotherapy and pharmacology. 2005, Vol 56, issn 0344-5704, s90-s93, SUP1Article

A phase II study of paclitaxel plus cisplatin for advanced non-small-cell lung cancer in Japanese patientsSAKAI, Hiroshi; YONEDA, Shuichi; TAMURA, Tomohide et al.Cancer chemotherapy and pharmacology. 2001, Vol 48, Num 6, pp 499-503, issn 0344-5704Article

Bodyweight change during the first 5 days of chemotherapy as an indicator of cisplatin renal toxicitySEKINE, Ikuo; YAMADA, Kazuhiko; NOKIHARA, Hiroshi et al.Cancer science. 2007, Vol 98, Num 9, pp 1408-1412, issn 1347-9032, 5 p.Article

Pertuzumab, a novel HER dimerization inhibitor, inhibits the growth of human lung cancer cells mediated by the HER3 signaling pathwaySAKAI, Kazuko; YOKOTE, Hideyuki; MURAKAMI-MUROFUSHI, Kimiko et al.Cancer science. 2007, Vol 98, Num 9, pp 1498-1503, issn 1347-9032, 6 p.Article

Geographic variation in the second-line treatment of non-small cell lung cancerEDELMAN, Martin J; SEKINE, Ikuo; TAMURA, Tomohide et al.Seminars in oncology. 2006, Vol 33, Num 1, issn 0093-7754, S39-S44, SUP1Article

Synergistic interactions between the synthetic retinoid tamibarotene and glucocorticoids in human myeloma cellsFUKUI, Tomoya; KODERA, Yasuo; NISHIO, Kazuto et al.Cancer science. 2009, Vol 100, Num 6, pp 1137-1143, issn 1347-9032, 7 p.Article

Small in-frame deletion in the epidermal growth factor receptor as a target for ZD6474ARAO, Tokuzo; FUKUMOTO, Hisao; TAKEDA, Masayuki et al.Cancer research (Baltimore). 2004, Vol 64, Num 24, pp 9101-9104, issn 0008-5472, 4 p.Article

Long-term follow-up of patients with unresectable locally advanced non-small cell lung cancer treated with chemoradiotherapy: A retrospective analysis of the data from the Japan Clinical Oncology Group Trials (JCOG0003A)OHE, Yuichiro; ISHIZUKA, Naoki; TAMURA, Tomohide et al.Cancer science. 2003, Vol 94, Num 8, pp 729-734, issn 1347-9032, 6 p.Article

Non-cross resistance of ZD0473 in acquired cisplatin-resistant lung cancer cell linesKAWAMURA-AKIYAMA, Yoshiko; KUSABA, Hitoshi; KANZAWA, Fumihiko et al.Lung cancer. 2002, Vol 38, Num 1, pp 43-50, issn 0169-5002Article

CPT-11 alters the circadian rhythm of dihydropyrimidine dehydrogenase mRNA in mouse liverSHIMIZU, Mikiko; TAMURA, Tomohide; YAMADA, Yasuhide et al.Japanese journal of cancer research. 2001, Vol 92, Num 5, pp 554-561, issn 0910-5050Article

A single-arm confirmatory study of amrubicin therapy in patients with refractory small-cell lung cancer: Japan Clinical Oncology Group Study (JCOG0901)MURAKAMI, Haruyasu; YAMAMOTO, Nobuyuki; SATOUCHI, Miyako et al.Lung cancer. 2014, Vol 84, Num 1, pp 67-72, issn 0169-5002, 6 p.Article

Close Association of UGT1A9 IVS1+399C>T with UGT1A1*28, *6, or *60 Haplotype and Its Apparent Influence on 7-Ethyl-10-hydroxycamptothecin (SN-38) Glucuronidation in JapaneseSAITO, Yoshiro; SAI, Kimie; TAMURA, Tomohide et al.Drug metabolism and disposition. 2009, Vol 37, Num 2, pp 272-276, issn 0090-9556, 5 p.Article