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The histamine H3 receptor (a target for new drugs)Leurs, Rob; Timmerman, Henk.Pharmacochemistry library. 1998, issn 0165-7208, isbn 0-444-82936-9, XI, 291 p, isbn 0-444-82936-9Book

Histamine and histaminergic ligands; a playground for medicinal chemistsTIMMERMAN, Henk.Il Farmaco (Pavia). 2002, Vol 57, Num 7, pp 549-550, issn 0014-827XConference Paper

Non-imidazole histamine H3 ligands. Part III. New 4-n-propylpiperazines as non-imidazole histamine H3-antagonistsWALCZYNSKI, Krzysztof; ZUIDERVELD, Obbe P; TIMMERMAN, Henk et al.European journal of medicinal chemistry. 2005, Vol 40, Num 1, pp 15-23, issn 0223-5234, 9 p.Article

Modulation of histamine H2 receptor signalling by G-protein-coupled receptor kinase 2 and 3RODRIGUEZ-PENA, Maria Sol; TIMMERMAN, Henk; LEURS, Rob et al.British journal of pharmacology. 2000, Vol 131, Num 8, pp 1707-1715, issn 0007-1188Article

The adenosine A3 receptor and its ligandsVAN MUIJLWIJK-KOEZEN, Jacqueline E; TIMMERMAN, Henk; IJZERMAN, Adriaan P et al.Progress in medicinal chemistry. 2001, Vol 38, pp 61-113, issn 0079-6468Article

Role of histamine H3 receptors in control of mouse intestinal motility in vivo and in vitro: Comparison with α2-AdrenoceptorsPOZZOLI, Cristina; TODOROV, Simeon; SCHUNACK, Walter et al.Digestive diseases and sciences. 2002, Vol 47, Num 5, pp 1065-1072, issn 0163-2116Article

4-Benzyl-lH-imidazoles with Oxazoline Termini as Histamine H3 Receptor AgonistsWIJTMANS, Maikel; CELANIRE, Sylvain; LEBON, Florence et al.Journal of medicinal chemistry (Print). 2008, Vol 51, Num 10, pp 2944-2953, issn 0022-2623, 10 p.Article

Mutational analysis of the histamine H1-receptor binding pocket of histaprodifensBRUYSTERS, Martijn; PERTZ, Heinz H; TEUNISSEN, Aloys et al.European journal of pharmacology. 2004, Vol 487, Num 1-3, pp 55-63, issn 0014-2999, 9 p.Article

Development of a pharmacophore model for histamine H3 receptor antagonists, using the newly developed molecular modeling program SLATEDE ESCH, Iwan J. P; MILLS, James E. J; TIMMERMAN, Henk et al.Journal of medicinal chemistry (Print). 2001, Vol 44, Num 11, pp 1666-1674, issn 0022-2623Article

Histamine H1 receptor ligands. Part II. Synthesis and in vitro pharmacology of 2-[2-(phenylamino)thiazol-4-yl]ethanamine and 2-(2-benzhydrylthiazol-4-yl)ethanamine derivativesWALCZYNSKI, Krzysztof; GURYN, Roman; ZUIDERVELD, Obbe P et al.Il Farmaco (Pavia). 2000, Vol 55, Num 9-10, pp 569-574, issn 0014-827XArticle

Histamine protects against NMDA-induced necrosis in cultured cortical neurons through H2 receptor/cyclic AMP/protein kinase A and H3 receptor/GABA release pathwaysHAIBIN DAI; ZHONGMIAO ZHANG; YONGPIN ZHU et al.Journal of neurochemistry. 2006, Vol 96, Num 5, pp 1390-1400, issn 0022-3042, 11 p.Article

Medicinal chemistry education : What is needed and where is it going?KROGSGAARD-LARSEN, Povl; PELLICIARI, Roberto; DE SOUZA, Noel et al.Drug development research. 2005, Vol 66, Num 1, pp 1-8, issn 0272-4391, 8 p.Article

Improgan antinociception does not require neuronal histamine or histamine receptorsMOBARAKEH, Jalal Izadi; NALWALK, Julia W; WATANABE, Takeshi et al.Brain research. 2003, Vol 974, Num 1-2, pp 146-152, issn 0006-8993, 7 p.Article

SYNOPSIS: Synthesize and optimize system in silicoVINKERS, H. Maarten; DE JONGE, Marc R; DAEYAERT, Frederik F. D et al.Journal of medicinal chemistry (Print). 2003, Vol 46, Num 13, pp 2765-2773, issn 0022-2623, 9 p.Article

A chemical switch for the modulation of the functional activity of higher homologues of histamine on the human histamine H3 receptor : Effect of various substitutions at the primary amino functionGOVONI, Marinella; LIM, Herman D; EL-ATMIOUI, Dris et al.Journal of medicinal chemistry (Print). 2006, Vol 49, Num 8, pp 2549-2557, issn 0022-2623, 9 p.Article

N-substituted piperidinyl alkyl imidazoles : Discovery of methimepip as a potent and selective histamine H3 receptor agonistKITBUNNADAJ, Ruengwit; HASHIMOTO, Takeshi; CORUZZI, Gabriella et al.Journal of medicinal chemistry (Print). 2005, Vol 48, Num 6, pp 2100-2107, issn 0022-2623, 8 p.Article

New high affinity H3 receptor agonists without a basic side chainKITBUNNADAJ, Ruengwit; HOFFMANN, Marcel; LEURS, Rob et al.Bioorganic & medicinal chemistry. 2005, Vol 13, Num 23, pp 6309-6323, issn 0968-0896, 15 p.Article

New insights into the second generation antihistaminesWALSH, Garry M; ANNUNZIATO, Lucio; FROSSARD, Nelly et al.Drugs (Basel). 2001, Vol 61, Num 2, pp 207-236, issn 0012-6667Article

Pharmacogenomic and structural analysis of constitutive G protein-coupled receptor activitySMIT, Martine J; VISCHER, Henry F; BAKKER, Remko A et al.Annual review of pharmacology and toxicology. 2007, Vol 47, pp 53-87, issn 0362-1642, 35 p.Article

Synthesis and pharmacological identification of neutral histamine H1-Receptor antagonistsGOVONI, Marinella; BAKKER, Remko A; VAN DE WETERING, Ineke et al.Journal of medicinal chemistry (Print). 2003, Vol 46, Num 26, pp 5812-5824, issn 0022-2623, 13 p.Article

Synthesis and use of FSCPX, an irreversible adenosine A1 antagonist, as a 'Receptor knock-down' toolVAN MUIJLWIJK-KOEZEN, Jacqueline E; TIMMERMAN, Henk; VAN DER SLUIS, Richard P et al.Bioorganic & medicinal chemistry letters (Print). 2001, Vol 11, Num 6, pp 815-818, issn 0960-894XArticle

A role for spinal, but not supraspinal, α2 adrenergic receptors in the actions of improgan, a powerful, non-opioid analgesicSVOKOS, Konstantina; NALWALK, Julia W; LEURS, Rob et al.Brain research. 2001, Vol 923, Num 1-2, pp 12-19, issn 0006-8993Article

Synthesis and structure-activity relationship of 3-phenyl-3H-quinazolin-4-one derivatives as CXCR3 chemokine receptor antagonistsSTORELLI, Stefania; VERDIJK, Pauline; VERZIJL, Dennis et al.Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 11, pp 2910-2913, issn 0960-894X, 4 p.Article

Differential activation of murine herpesvirus 68- and Kaposi's sarcoma-associated herpesvirus-encoded ORF74 G protein-coupled receptors by human and murine chemokinesVERZIJL, Dennis; FITZSIMONS, Carlos P; VAN DIJK, Marie et al.Journal of virology. 2004, Vol 78, Num 7, pp 3343-3351, issn 0022-538X, 9 p.Article

Synthesis and structure-activity relationships of conformationally constrained histamine H3 receptor agonistsKITBUNNADAJ, Ruengwit; ZUIDERVELD, Obbe P; TIMMERMAN, Henk et al.Journal of medicinal chemistry (Print). 2003, Vol 46, Num 25, pp 5445-5457, issn 0022-2623, 13 p.Article

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