The two-compartment recirculatory pharmacokinetic model: an introduction to recirculatory pharmacokinetic conceptsUPTON, R. N.British Journal of Anaesthesia. 2004, Vol 92, Num 4, pp 475-484, issn 0007-0912, 10 p.Article

A model of the first pass passage of drugs from i.v. injection site to the heart-parameter estimates for lignocaine in the sheepUPTON, R. N.British Journal of Anaesthesia. 1996, Vol 77, Num 6, pp 764-772, issn 0007-0912Article

Theoretical aspects of P-glycoprotein mediated drug efflux on the distribution volume of anaesthetic-related drugs in the brainUPTON, R. N.Anaesthesia and intensive care. 2002, Vol 30, Num 2, pp 183-191, issn 0310-057XArticle

An analysis of errors arising from the direct use of mass balance principles to describe regional drug uptake and elutionUPTON, R. N.Journal of pharmacokinetics and biopharmaceutics. 1994, Vol 22, Num 4, pp 309-321, issn 0090-466XArticle

Regional pharmacokinetics. I, Physiological and physicochemical basisUPTON, R. N.Biopharmaceutics & drug disposition. 1990, Vol 11, Num 8, pp 647-662, issn 0142-2782, 16 p.Article

A model of the kinetics and dynamics of induction of anaesthesia in sheep : variable estimation for thiopental and comparison with propofolUPTON, R. N; LUDBROOK, G. L.British Journal of Anaesthesia. 1999, Vol 82, Num 6, pp 890-899, issn 0007-0912Article

Diffusion-limited, but not perfusion-limited, compartmental models describe cerebral nitrous oxide kinetics at high and low cerebral blood flowsDOOLETTE, D. J; UPTON, R. N; GRANT, C et al.Journal of pharmacokinetics and biopharmaceutics. 1998, Vol 26, Num 6, pp 649-672, issn 0090-466XArticle

A physiological model of induction of anaesthesia with propofol in sheep. 1. Structure and estimation of variablesUPTON, R. N; LUDBROOK, G. L.British Journal of Anaesthesia. 1997, Vol 79, Num 4, pp 497-504, issn 0007-0912Article

A dose escalation study in sheep of the effects of the benzodiazepine CNS 7056 on sedation, the EEC and the respiratory and cardiovascular systemsUPTON, R. N; MARTINEZ, A. M; GRANT, C et al.British journal of pharmacology. 2008, Vol 155, Num 1, pp 52-61, issn 0007-1188, 10 p.Article

Countercurrent compartmental models describe hind limb skeletal muscle helium kinetics at resting and low blood flows in sheepDOOLETTE, D. J; UPTON, R. N; GRANT, C et al.Acta physiologica scandinavica. 2005, Vol 185, Num 2, pp 109-121, issn 0001-6772, 13 p.Article

A physiological model of induction of anaesthesia with propofol in sheep. 2. Model analysis and implications for dose requirementsLUDBROOK, G. L; UPTON, R. N.British Journal of Anaesthesia. 1997, Vol 79, Num 4, pp 505-513, issn 0007-0912Article

Skeletal muscle kinetics of propofol in anaesthetized sheep : effect of altered muscle blood flowZHENG, D; UPTON, R. N; MARTINEZ, A et al.Xenobiotica (London. Print). 2000, Vol 30, Num 11, pp 1079-1090, issn 0049-8254Article

The difficult airway : Propofol infusion as an alternative to gaseous inductionLUDBROOK, G. L; HITCHCOCK, M; UPTON, R. N et al.Anaesthesia and intensive care. 1997, Vol 25, Num 1, pp 71-73, issn 0310-057XArticle

An estimate of the rate of direct drug diffusion from the surface of heat and kidney : implications for their representation as compartmentsYI FEI HUANG; UPTON, R. N.Biopharmaceutics & drug disposition. 1993, Vol 14, Num 8, pp 647-658, issn 0142-2782Article

Comparison of the sedative properties of CNS 7056, midazolam, and propofol in sheepUPTON, R. N; MARTINEZ, A. M; GRANT, C et al.British journal of anaesthesia. 2009, Vol 103, Num 6, pp 848-857, issn 0007-0912, 10 p.Article

Diffusion-limited tissue equilibration and arteriovenous diffusion shunt describe skeletal muscle nitrous oxide kinetics at high and low blood flows in sheepDOOLETTE, D. J; UPTON, R. N; ZHENG, D et al.Acta physiologica scandinavica. 2001, Vol 172, Num 3, pp 167-177, issn 0001-6772Article

The cerebral and systemic kinetics of thiopentone and propofol in halothane anaesthetized sheepUPTON, R. N; LUDBROOK, G. L; GRANT, C et al.Anaesthesia and intensive care. 2001, Vol 29, Num 2, pp 117-123, issn 0310-057XConference Paper

Influence of cardiac output, injection time and injection volume on the initial mixing of drugs with venous blood after I.V. bolus administration to sheepUPTON, R. N; HUANG, Y. F.British Journal of Anaesthesia. 1993, Vol 70, Num 3, pp 333-338, issn 0007-0912Article

Cerebral and lung kinetics of morphine in conscious sheep after short intravenous infusionsUPTON, R. N; LUDBROOK, G. L; MARTINEZ, A. M et al.British Journal of Anaesthesia. 2003, Vol 90, Num 6, pp 750-758, issn 0007-0912, 9 p.Article

A mixture of alfentanil and morphine for rapid postoperative loading with opioid: theoretical basis and initial clinical investigationLUDBROOK, G. L; MACINTYRE, P. E; DOUGLAS, H et al.Anaesthesia. 2001, Vol 56, Num 8, pp 739-744, issn 0003-2409Article

Regional pharmacokinetics. II, Experimental methodsUPTON, R. N; RUNCIMAN, W. B; MATHER, L. E et al.Biopharmaceutics & drug disposition. 1990, Vol 11, Num 9, pp 741-752, issn 0142-2782, 12 p.Article

The effect of infusions of adrenaline, noradrenaline and dopamine on cerebral autoregulation under isoflurane anaesthesia in an ovine modelMYBURGH, J. A; UPTON, R. N; GRANT, C et al.Anaesthesia and intensive care. 2003, Vol 31, Num 3, pp 259-266, issn 0310-057X, 8 p.Article

Development and validation of a recirculatory physiological model of the myocardial concentrations of lignocaine after intravenous administration in sheepUPTON, R. N; ZHENG, D. A; GRANT, C et al.Journal of pharmacy and pharmacology. 2000, Vol 52, Num 2, pp 181-189, issn 0022-3573Article

Myocardial pharmacokinetics of thiopental in sheep after short-term administration : Relationship to thiopental-induced reductions in myocardial contractilityUPTON, R. N; YI FEI HUANG; GRANT, C et al.Journal of pharmaceutical sciences. 1996, Vol 85, Num 8, pp 863-867, issn 0022-3549Article

The hemodynamic effects of intravenous bolus doses of meperidine in conscious sheepYI FEI HUANG; UPTON, R. N; RUTTEN, A. J et al.Anesthesia and analgesia. 1994, Vol 78, Num 3, pp 442-449, issn 0003-2999Article