Relationships between steady state blood concentrations and cardiac output during intravenous infusionsUPTON, Richard N.Biopharmaceutics & drug disposition. 2000, Vol 21, Num 2, pp 69-76, issn 0142-2782Article

A physiologically based, recirculatory model of the kinetics and dynamics ofpropofol in manUPTON, Richard N; LUDBROOK, Guy.Anesthesiology (Philadelphia). 2005, Vol 103, Num 2, pp 344-352, issn 0003-3022, 9 p.Article

A pharmacokinetic model for L-carnitine in patients receiving haemodialysisFORNASINI, Gianfranco; UPTON, Richard N; EVANS, Allan M et al.British journal of clinical pharmacology. 2007, Vol 64, Num 3, pp 335-345, issn 0306-5251, 11 p.Article

The effect of hypoxic hypoxia on the systemic and myocardial pharmacokinetics and dynamics of lidocaine in sheepYI FEI HUANG; UPTON, Richard N.Journal of pharmaceutical sciences. 2003, Vol 92, Num 1, pp 180-189, issn 0022-3549, 10 p.Article

The contribution of the coronary concentrations of propofol to its cardiovascular effects in anesthetized sheepDA ZHENG; UPTON, Richard N; MARTINEZ, Allison M et al.Anesthesia and analgesia. 2003, Vol 96, Num 6, pp 1589-1597, issn 0003-2999, 9 p.Article

In vivo cerebral pharmacokinetics and pharmacodynamics of diazepam and midazolam after short intravenous infusion administration in sheepUPTON, Richard N; LUDBROOK, Guy L; GRANT, Cliff et al.Journal of pharmacokinetics and biopharmaceutics. 2001, Vol 28, Num 2, pp 129-153, issn 0090-466XArticle

Epinephrine, norepinephrine and dopamine infusions decrease propofol concentrations during continuous propofol infusion in an ovine modelMYBURGH, John A; UPTON, Richard N; GRANT, Cliff et al.Intensive care medicine (Print). 2001, Vol 27, Num 1, pp 276-282, issn 0342-4642Article

The effect of infusions of adrenaline, noradrenaline and dopamine on cerebral autoregulation under propofol anaesthesia in an ovine modelMYBURGH, John A; UPTON, Richard N; GRANT, Cliff et al.Intensive care medicine (Print). 2003, Vol 29, Num 5, pp 817-824, issn 0342-4642, 8 p.Article

The effects of indomethacin on intracranial pressure and cerebral hemodynamics during isoflurane or propofol anesthesia in sheep with intracranial hypertensionRASMUSSEN, Mads; UPTON, Richard N; GRANT, Cliff et al.Anesthesia and analgesia. 2006, Vol 102, Num 6, pp 1823-1829, issn 0003-2999, 7 p.Article

Pharmacokinetic/Pharmacodynamic Relationships of Transdermal Buprenorphine and Fentanyl in Experimental Human Pain ModelsANDRESEN, Trine; UPTON, Richard N; FOSTER, David J. R et al.Basic & clinical pharmacology & toxicology (Print). 2011, Vol 108, Num 4, pp 274-284, issn 1742-7835, 11 p.Article

Inhibition of Morphine Metabolism by KetamineXIAOXIN QI; EVANS, Allan M; JIPING WANG et al.Drug metabolism and disposition. 2010, Vol 38, Num 5, pp 728-731, issn 0090-9556, 4 p.Article

The Performance of Compartmental and Physiologically Based Recirculatory Pharmacokinetic Models for Propofol: A Comparison Using Bolus, Continuous, and Target-Controlled Infusion DataMASUI, Kenichi; UPTON, Richard N; DOUFAS, Anthony G et al.Anesthesia and analgesia. 2010, Vol 111, Num 2, pp 368-379, issn 0003-2999, 12 p.Article

The acute disposition of (R)- and (S)-methadone in brain and lung of sheepFOSTER, David J. R; UPTON, Richard N; SOMOGYI, Andrew A et al.Journal of pharmacokinetics and pharmacodynamics (Print). 2005, Vol 32, Num 3-4, pp 547-570, issn 1567-567X, 24 p.Article

Pharmacokinetic-pharmacodynamic relationship of bosutinib in patients with chronic phase chronic myeloid leukemiaHSYU, Poe-Hirr; MOULD, Diane R; UPTON, Richard N et al.Cancer chemotherapy and pharmacology. 2013, Vol 71, Num 1, pp 209-218, issn 0344-5704, 10 p.Article

Reduced intrathoracic blood volume and left and right ventricular dimensions in patients with severe emphysema : An MRI studyJÖRGENSEN, Kirsten; MÜLLER, Markus F; NEL, Jacqueline et al.Chest. 2007, Vol 131, Num 4, pp 1050-1057, issn 0012-3692, 8 p.Article

Pharmacodynamic Modelling of Placebo and Buprenorphine Effects on Event-Related Potentials in Experimental PainJUUL, Rasmus V; FOSTER, David J. R; UPTON, Richard N et al.Basic & clinical pharmacology & toxicology (Print). 2014, Vol 115, Num 4, pp 343-351, issn 1742-7835, 9 p.Article

Population pharmacokinetics of buprenorphine following a two-stage intravenous infusion in healthy volunteersJENSEN, Mette L; FOSTER, David J. R; UPTON, Richard N et al.European journal of clinical pharmacology. 2007, Vol 63, Num 12, pp 1153-1159, issn 0031-6970, 7 p.Article

The effect of altered cerebral blood flow on the cerebral kinetics of Thiopental and propofol in sheepUPTON, Richard N; LUDBROOK, Guy L; GRANT, Cliff et al.Anesthesiology (Philadelphia). 2000, Vol 93, Num 4, pp 1085-1094, issn 0003-3022Article

Pharmacokinetic-Pharmacodynamic Relationships of Cognitive and Psychomotor Effects of Intravenous Buprenorphine Infusion in Human VolunteersJENSEN, Mette L; SJØGREN, Per; UPTON, Richard N et al.Basic & clinical pharmacology & toxicology (Print). 2008, Vol 103, Num 1, pp 94-101, issn 1742-7835, 8 p.Article

Blood-brain equilibration kinetics of levo-α-acetyl-methadol using a chronically instrumented sheep preparationFOSTER, David J. R; JENSEN, Mette L; UPTON, Richard N et al.British journal of pharmacology. 2006, Vol 147, Num 2, pp 209-217, issn 0007-1188, 9 p.Article

Cerebral kinetics of oxycodone in conscious sheepVILLESEN, Hanne H; FOSTER, David J. R; UPTON, Richard N et al.Journal of pharmaceutical sciences. 2006, Vol 95, Num 8, pp 1666-1676, issn 0022-3549, 11 p.Article