Inhibitory potential of nonsteroidal anti-inflammatory drugs on UDP-glucuronosyltransferase 2B7 in human liver microsomesMANO, Yuji; USUI, Takashi; KAMIMURA, Hidetaka et al.European journal of clinical pharmacology. 2007, Vol 63, Num 2, pp 211-216, issn 0031-6970, 6 p.Article

Substrate-dependent modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1) by propofol in recombinant human UGT1A1 and human liver microsomesMANO, Yuji; USUI, Takashi; KAMIMURA, Hidetaka et al.Basic & clinical pharmacology & toxicology (Print). 2007, Vol 101, Num 3, pp 211-214, issn 1742-7835, 4 p.Article

Hepatobiliary transport of YM466, a novel factor Xa inhibitor, in ratsMANO, Yuji; USUI, Takashi; KAMIMURA, Hidetaka et al.European journal of drug metabolism and pharmacokinetics. 2006, Vol 31, Num 2, pp 117-121, issn 0378-7966, 5 p.Article

Species Differences in Inhibition Potential of Nonsteroidal Anti-Inflammatory Drugs against Estradiol 3β-Glucuronidation between Rats, Dogs, and HumansMANO, Yuji; USUI, Takashi; KAMIMURA, Hidetaka et al.Journal of pharmaceutical sciences. 2008, Vol 97, Num 7, pp 2805-2810, issn 0022-3549, 6 p.Article

Contribution of UDP-glucuronosyltransferases 1A9 and 2B7 to the glucuronidation of indomethacin in the human liverMANO, Yuji; USUI, Takashi; KAMIMURA, Hidetaka et al.European journal of clinical pharmacology. 2007, Vol 63, Num 3, pp 289-296, issn 0031-6970, 8 p.Article

In vitro inhibitory effects of non-steroidal antiinflammatory drugs on UDP-glucuronosyltransferase 1A1-catalysed estradiol 3β-glucuronidation in human liver microsomesMANO, Yuji; USUI, Takashi; KAMIMURA, Hidetaka et al.Biopharmaceutics & drug disposition. 2005, Vol 26, Num 1, pp 35-39, issn 0142-2782, 5 p.Article

A liquid chromatographic-tandem mass spectrometric method for the determination of YM466, a novel Factor Xa inhibitor, in rat plasmaMANO, Yuji; USUI, Takashi; KAMIMURA, Hidetaka et al.Journal of pharmaceutical and biomedical analysis. 2004, Vol 36, Num 4, pp 883-887, issn 0731-7085, 5 p.Article

Predominant contribution of UDP-glucuronosyltransferase 2B7 in the glucuronidation of racemic flurbiprofen in the human liverMANO, Yuji; USUI, Takashi; KAMIMURA, Hidetaka et al.Drug metabolism and disposition. 2007, Vol 35, Num 7, pp 1182-1187, issn 0090-9556, 6 p.Article

The UDP-glucuronosyltransferase 2B7 isozyme is responsible for gemfibrozil glucuronidation in the human liverMANO, Yuji; USUI, Takashi; KAMIMURA, Hidetaka et al.Drug metabolism and disposition. 2007, Vol 35, Num 11, pp 2040-2044, issn 0090-9556, 5 p.Article

Effects of β-estradiol and propofol on the 4-methylumbelliferone glucuronidation in recombinant human UGT isozymes 1A1, 1A8 and 1A9MANO, Yuji; USUI, Takashi; KAMIMURA, Hidetaka et al.Biopharmaceutics & drug disposition. 2004, Vol 25, Num 8, pp 339-344, issn 0142-2782, 6 p.Article

Pharmacokinetics of YM466, a new factor Xa inhibitor, in rats and dogsMANO, Yuji; USUI, Takashi; KAMIMURA, Hidetaka et al.European journal of drug metabolism and pharmacokinetics. 2004, Vol 29, Num 1, pp 7-13, issn 0378-7966, 7 p.Article

Comparison of inhibition potentials of drugs against zidovudine glucuronidation in rat hepatocytes and liver microsomesMANO, Yuji; USUI, Takashi; KAMIMURA, Hidetaka et al.Drug metabolism and disposition. 2007, Vol 35, Num 4, pp 602-606, issn 0090-9556, 5 p.Article

Identification of human UDP-glucuronosyltransferase responsible for the glucuronidation of niflumic acid in human liverMANO, Yuji; USUI, Takashi; KAMIMURA, Hidetaka et al.Pharmaceutical research. 2006, Vol 23, Num 7, pp 1502-1508, issn 0724-8741, 7 p.Article

In vitro drug interaction between diflunisal and indomethacin via glucuronidation in humansMANO, Yuji; USUI, Takashi; KAMIMURA, Hidetaka et al.Biopharmaceutics & drug disposition. 2006, Vol 27, Num 6, pp 267-273, issn 0142-2782, 7 p.Article

In vitro inhibitory effects of non-steroidal anti-inflammatory drugs on 4-methylumbelliferone glucuronidation in recombinant human UDP-glucuronosyltransferase 1A9-potent inhibition by niflumic acidMANO, Yuji; USUI, Takashi; KAMIMURA, Hidetaka et al.Biopharmaceutics & drug disposition. 2006, Vol 27, Num 1, pp 1-6, issn 0142-2782, 6 p.Article

Effects of bosentan, an endothelin receptor antagonist, on bile salt export pump and multidrug resistance-associated protein 2MANO, Yuji; USUI, Takashi; KAMIMURA, Hidetaka et al.Biopharmaceutics & drug disposition. 2007, Vol 28, Num 1, pp 13-18, issn 0142-2782, 6 p.Article

Utility of P-Glycoprotein and Organic Cation Transporter 1 Double-Transfected LLC-PK1 Cells for Studying the Interaction of YM155 Monobromide, Novel Small-Molecule Survivin Suppressant, with P-GlycoproteinIWAI, Megumi; MINEMATSU, Tsuyoshi; QUN LI et al.Drug metabolism and disposition. 2011, Vol 39, Num 12, pp 2314-2320, issn 0090-9556, 7 p.Article

Involvement of Human Organic Cation Transporter 1 in the Hepatic Uptake of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1 H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel, Small Molecule Survivin SuppressantIWAI, Megumi; MINEMATSU, Tsuyoshi; NARIKAWA, Shinichi et al.Drug metabolism and disposition. 2009, Vol 37, Num 9, pp 1856-1863, issn 0090-9556, 8 p.Article

Role of Organic Anion Transporters in the Pharmacokinetics of Zonampanel, an a-Amino-3-hydroxy-5-methylisoxazole-4-propionate Receptor Antagonist, in RatsMINEMATSU, Tsuyoshi; HASHIMOTO, Tadashi; AOKI, Toshiko et al.Drug metabolism and disposition. 2008, Vol 36, Num 8, pp 1496-1504, issn 0090-9556, 9 p.Article

Absorption, distribution, metabolism and excretion of YM466, a novel factor Xa inhibitor, in ratsMANO, Yuji; SONODA, Takuya; NAKAMURA, Eiji et al.Biopharmaceutics & drug disposition. 2004, Vol 25, Num 6, pp 253-260, issn 0142-2782, 8 p.Article

A surface plasmon resonance sensor on a compact disk-type microfluidic deviceHEMMI, Akihide; USUI, Takashi; MOTO, Akihiro et al.Journal of separation science (Print). 2011, Vol 34, Num 20, pp 2913-2919, issn 1615-9306, 7 p.Article

The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibodyNAKASHIMA, Ran; IMURA, Yoshitaka; OKAWA, Katsuya et al.Rheumatology (Oxford. Print). 2010, Vol 49, Num 3, pp 433-440, issn 1462-0324, 8 p.Article

Investigation of Long-Term Retention of Unchanged (―)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide, A Novel Funny If Current Channel Inhibitor, and Its Metabolites in the Eyeball and Thoracic Aorta of RatsUMEHARA, Ken-Ichi; NAKADA, Naoyuki; NOGUCHI, Kiyoshi et al.Drug metabolism and disposition. 2009, Vol 37, Num 11, pp 2137-2144, issn 0090-9556, 8 p.Article

Characterization of Human Organic Cation Transporter 1 (OCT1/SLC22A1)- and OCT2 (SLC22A2)-Mediated Transport of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel Small Molecule Survivin SuppressantMINEMATSU, Tsuyoshi; IWAI, Megumi; UMEHARA, Ken-Ichi et al.Drug metabolism and disposition. 2010, Vol 38, Num 1, pp 1-4, issn 0090-9556, 4 p.Article

Time-Dependent Inhibitory Effects of (1R,9S,12S,13R,14S,17R,18F,21S,23S,24R,25S,27R)-1,14-Dihydroxy-12-(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylvinyl-23,25-dimethoxy-13,19,21,27-tetramethyl-17-(2-oxopropyl)-11,28-dioxa-4-azatricyclo[22.3.1.0^4.9]octacos-18-ene-2,3,10,16-tetrone (FK1706), a Novel Nonimmunosuppressive Immunophilin Ligand, on CYP3A4/5 Activity in Humans in Vivo and in VitroMINEMATSU, Tsuyoshi; LEE, Jennifer; JIUHONG ZHA et al.Drug metabolism and disposition. 2010, Vol 38, Num 2, pp 249-259, issn 0090-9556, 11 p.Article