The pharmaceutical potential of histone deacetylase inhibitorsELAUT, Greetje; ROGIERS, Vera; VANHAECKE, Tamara et al.Current pharmaceutical design. 2007, Vol 13, Num 25, pp 2584-2620, issn 1381-6128, 37 p.Article

Trichostatin A: like hydroxamate histone deacetylase inhibitors as therapeutic agents: Toxicological point of viewVANHAECKE, Tamara; PAPELEU, Peggy; ELAUT, Greetje et al.Current medicinal chemistry. 2004, Vol 11, Num 12, pp 1629-1643, issn 0929-8673, 15 p.Article

Primary hepatocyte cultures as prominent in vitro tools to study hepatic drug transportersRAMBOER, Eva; VANHAECKE, Tamara; ROGIERS, Vera et al.Drug metabolism reviews (Softcover ed.). 2013, Vol 45, Num 2, pp 196-217, issn 0360-2532, 22 p.Article

Differential role of epigenetic modulators in malignant and normal stem cells : a novel tool in preclinical in vitro toxicology and clinical therapySNYKERS, Sarah; VINKEN, Mathieu; ROGIERS, Vera et al.Archives of toxicology. 2007, Vol 81, Num 8, pp 533-544, issn 0340-5761, 12 p.Article

Hydroxypropyl-β-cyclodextrin as delivery system for thyroid hormones, regulating glutathione S-transferase expression in rat hepatocyte co-culturesVANHAECKE, Tamara; DERDE, Marie-Paule; VERCRUYSSE, Antoine et al.Biochemical pharmacology. 2001, Vol 61, Num 9, pp 1073-1078, issn 0006-2952Article

Spontaneous apoptosis, necrosis, energy status, glutathione levels and biotransformation capacities of isolated rat hepatocytes in suspension : Effect of the incubation mediumELAUT, Greetje; VANHAECKE, Tamara; VANDER HEYDEN, Yvan et al.Biochemical pharmacology. 2005, Vol 69, Num 12, pp 1829-1838, issn 0006-2952, 10 p.Article

Effect of the histone deacetylase inhibitor trichostatin A on spontaneous apoptosis in various types of adult rat hepatocyte culturesVANHAECKE, Tamara; HENKENS, Tom; KASS, George E. N et al.Biochemical pharmacology. 2004, Vol 68, Num 4, pp 753-760, issn 0006-2952, 8 p.Article

Opportunities for an alternative integrating testing strategy for carcinogen hazard assessment?DOKTOROVA, Tatyana Y; PAUWELS, Marleen; VINKEN, Mathieu et al.Critical reviews in toxicology. 2012, Vol 42, Num 2, pp 91-106, issn 1040-8444, 16 p.Article

Differential effects of histone deacetylase inhibitors in tumor and normal cells: What is the toxicological relevance?PAPELEU, Peggy; VANHAECKE, Tamara; ELAUT, Greetje et al.Critical reviews in toxicology. 2005, Vol 35, Num 4, pp 363-378, issn 1040-8444, 16 p.Article

Effect of long-term ethanol exposure on the acinar distribution of hepatic glutathione S-transferaseVANHAECKE, Tamara; LINDROS, Kai O; OINONEN, Teija et al.Drug metabolism and disposition. 2000, Vol 28, Num 12, pp 1470-1474, issn 0090-9556Article

Differential effects of hydroxamate histone deacetylase inhibitors on cellular functionality and gap junctions in primary cultures of mitogen-stimulated hepatocytesHENKENS, Tom; VINKEN, Mathieu; LUKASZUK, Aneta et al.Toxicology letters. 2008, Vol 178, Num 1, pp 37-43, issn 0378-4274, 7 p.Article

The novel histone deacetylase inhibitor 4-Me₂N-BAVAH differentially affects cell junctions between primary hepatocytesVINKEN, Mathieu; HENKENS, Tom; SNYKERS, Sarah et al.Toxicology (Amsterdam). 2007, Vol 236, Num 1-2, pp 92-102, issn 0300-483X, 11 p.Article

Simple and quick method for whole-liver decellularization: a novel in vitro three-dimensional bioengineering tool?DE KOCK, Joery; CEELEN, Liesbeth; DE SPIEGELAERE, Ward et al.Archives of toxicology. 2011, Vol 85, Num 6, pp 607-612, issn 0340-5761, 6 p.Article

Critical selection of reliable reference genes for gene expression study in the HepaRG cell lineCEELEN, Liesbeth; DE SPIEGELAERE, Ward; DAVID, Michael et al.Biochemical pharmacology. 2011, Vol 81, Num 10, pp 1255-1261, issn 0006-2952, 7 p.Article

Biochemical Characterisation of an In Vitro Model of Hepatocellular Apoptotic Cell DeathVINKEN, Mathieu; DECROCK, Elke; DE VUYST, Elke et al.ATLA. Alternatives to laboratory animals. 2009, Vol 37, Num 2, pp 209-218, issn 0261-1929, 10 p.Article

Biology and Pathobiology of Gap Junctional Channels in HepatocytesVINKEN, Mathieu; HENKENS, Tom; DE ROP, Evelien et al.Hepatology (Baltimore, Md.). 2008, Vol 47, Num 3, pp 1077-1088, issn 0270-9139, 12 p.Article

Influence of culture system and medium enrichment on sulfotransferase and sulfatase expression in male rat hepatocyte culturesSLAUS, Katrien; COUGHTRIE, Michael W. H; SHARP, Sheila et al.Biochemical pharmacology. 2001, Vol 61, Num 9, pp 1107-1117, issn 0006-2952Article

Trichostatin A, a critical factor in maintaining the functional differentiation of primary cultured rat hepatocytesHENKENS, Tom; PAPELEU, Peggy; ELAUT, Greetje et al.Toxicology and applied pharmacology. 2007, Vol 218, Num 1, pp 64-71, issn 0041-008X, 8 p.Article

Effect of ethanol on the expression of hepatic glutathione S-transferase : An in vivo/in vitro studyVANHAECKE, Tamara; LINDROS, Kai O; OINONEN, Teija et al.Biochemical pharmacology. 2000, Vol 60, Num 10, pp 1491-1496, issn 0006-2952Article

Role of epigenetics in liver-specific gene transcription, hepatocyte differentiation and stem cell reprogrammationSNYKERS, Sarah; HENKENS, Tom; DE ROP, Evelien et al.Journal of hepatology. 2009, Vol 51, Num 1, pp 187-211, issn 0168-8278, 25 p.Article

The carcinoGENOMICS project : Critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assaysVINKEN, Mathieu; DOKTOROVA, Tatyana; BORT, Roque et al.Mutation research. Reviews in mutation research. 2008, Vol 659, Num 3, pp 202-210, issn 1383-5742, 9 p.Article

Trichostatin A induces differential cell cycle arrests but does not induce apoptosis in primary cultures of mitogen-stimulated rat hepatocytesPAPELEU, Peggy; LOYER, Pascal; VANHAECKE, Tamara et al.Journal of hepatology. 2003, Vol 39, Num 3, pp 374-382, issn 0168-8278, 9 p.Article

Assessment of stability, toxicity and immunogenicity of new polymeric nanoreactors for use in enzyme replacement therapy of MNGIEDE VOCHT, Caroline; RANQUIN, An; WILLAERT, Ronnie et al.Journal of controlled release. 2009, Vol 137, Num 3, pp 246-254, issn 0168-3659, 9 p.Article

Involvement of cell junctions in hepatocyte culture functionalityVINKEN, Mathieu; PAPELEU, Peggy; SNYKERS, Sarah et al.Critical reviews in toxicology. 2006, Vol 36, Num 4, pp 299-318, issn 1040-8444, 20 p.Article

Characterization of spontaneous cell death in monolayer cultures of primary hepatocytesVINKEN, Mathieu; DECROCK, Elke; DOKTOROVA, Tatyana et al.Archives of toxicology. 2011, Vol 85, Num 12, pp 1589-1596, issn 0340-5761, 8 p.Article