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au.\*:("WEDGE, Stephen R")

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The Use and Refinement of Rodent Models in Anti-cancer Drug Discovery: A Review : RefinementCURWEN, Jon O; WEDGE, Stephen R.ATLA. Alternatives to laboratory animals. 2009, Vol 37, Num 2, pp 173-180, issn 0261-1929, 8 p.Article

Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinaseMORTLOCK, Andrew A; FOOTE, Kevin M; JOHNSON, Trevor et al.Journal of medicinal chemistry (Print). 2007, Vol 50, Num 9, pp 2213-2224, issn 0022-2623, 12 p.Article

Discovery of novel and potent thiazoloquinazolines as selective aurora A and B kinase inhibitorsJUNG, Frédéric H; PASQUET, Georges; DOUSSON, Cyril et al.Journal of medicinal chemistry (Print). 2006, Vol 49, Num 3, pp 955-970, issn 0022-2623, 16 p.Article

Placental growth factor neutralising antibodies give limited anti-angiogenic effects in an in vitro organotypic angiogenesis modelBRAVE, Sandra R; EBERLEIN, Cath; SHIBUYA, Masabumi et al.Angiogenesis (London). 2010, Vol 13, Num 4, pp 337-347, issn 0969-6970, 11 p.Article

Combination antiangiogenic and Androgen deprivation therapy for prostate cancer: A promising therapeutic approachNICHOLSON, Brian; GULDING, Kathryn; CONAWAY, Mark et al.Clinical cancer research. 2004, Vol 10, Num 24, pp 8728-8734, issn 1078-0432, 7 p.Article

Tumor Stromal Architecture Can Define the Intrinsic Tumor Response to VEGF-Targeted TherapySMITH, Neil R; BAKER, Dawn; WEDGE, Stephen R et al.Clinical cancer research (Print). 2013, Vol 19, Num 24, pp 6943-6956, issn 1078-0432, 14 p.Article

The kinase inhibitor O6-cyclohexylmethylguanine (NU2058) potentiates the cytotoxicity of cisplatin by mechanisms that are independent of its effect upon CDK2HARRISON, Luke R. E; OTTLEY, Christopher J; PEARSON, D. Graham et al.Biochemical pharmacology. 2009, Vol 77, Num 10, pp 1586-1592, issn 0006-2952, 7 p.Article

AZD2171 : A highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancerWEDGE, Stephen R; KENDREW, Jane; CHESTER, Rosemary et al.Cancer research (Baltimore). 2005, Vol 65, Num 10, pp 4389-4400, issn 0008-5472, 12 p.Article

AZD1152, a selective inhibitor of aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosisWILKINSON, Robert W; ODEDRA, Rajesh; BYTH, Kate F et al.Clinical cancer research. 2007, Vol 13, Num 12, pp 3682-3688, issn 1078-0432, 7 p.Article

Inhibition of Aurora-B kinase activity confers antitumor efficacy in preclinical mouse models of early and advanced gastrointestinal neoplasiaALFEREZ, Denis G; GOODLAD, Robert A; ODEDRA, Rajesh et al.International journal of oncology. 2012, Vol 41, Num 4, pp 1475-1485, issn 1019-6439, 11 p.Article

ZD6474, an inhibitor of vascular endothelial growth factor receptor tyrosine kinase, inhibits growth of experimental lung metastasis and production of malignant pleural effusions in a non-small cell lung cancer modelMATSUMORI, Yuka; YANO, Seiji; GOTO, Hisatsugu et al.Oncology research. 2006, Vol 16, Num 1, pp 15-26, issn 0965-0407, 12 p.Article

ZD6474, a potent inhibitor of Vascular endothelial growth factor signaling, combined with radiotherapy: Schedule-dependent enhancement of antitumor activityWILLIAMS, Kaye J; TELFER, Brian A; BRAVE, Sandra et al.Clinical cancer research. 2004, Vol 10, Num 24, pp 8587-8593, issn 1078-0432, 7 p.Article

Dynamic contrast-enhanced MRI of vascular changes induced by the VEGF-signalling inhibitor ZD4190 in human tumour xenograftsCHECKLEY, David; TESSIER, Jean J. L; WEDGE, Stephen R et al.Magnetic resonance imaging. 2003, Vol 21, Num 5, pp 475-482, issn 0730-725X, 8 p.Article

Anti-tumour and anti-vascular effects of cediranib (AZD2171) alone and in combination with other anti-tumour therapiesKENDREW, Jane; ODEDRA, Rajesh; LOGIE, Armelle et al.Cancer chemotherapy and pharmacology. 2013, Vol 71, Num 4, pp 1021-1032, issn 0344-5704, 12 p.Article

Expression of stromal genes associated with the angiogenic response are not differentiated between human tumour xenografts with divergent vascular morphologiesFARREN, Matthew; WESTON, Susie; WEDGE, Stephen R et al.Angiogenesis (London). 2012, Vol 15, Num 4, pp 555-568, issn 0969-6970, 14 p.Article

Synthesis and SAR of 1-acetanilide-4-aminopyrazole-substituted quinazolines : Selective inhibitors of Aurora B kinase with potent anti-tumor activityFOOTE, Kevin M; MORTLOCK, Andrew A; KEEN, Nicholas J et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 6, pp 1904-1909, issn 0960-894X, 6 p.Article

Novel 4-anilinoquinazolines with C-7 basic side chains: Design and structure activity relationship of a series of potent, orally active, VEGF receptor tyrosine kinase inhibitorsHENNEQUIN, Laurent F; STOKES, Elaine S. E; THOMAS, Andrew P et al.Journal of medicinal chemistry (Print). 2002, Vol 45, Num 6, pp 1300-1312, issn 0022-2623Article

ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administrationWEDGE, Stephen R; OGILVIE, Donald J; GRAHAM, George A et al.Cancer research (Baltimore). 2002, Vol 62, Num 16, pp 4645-4655, issn 0008-5472Article

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