RDEA119/BAY 869766: A Potent, Selective, Allosteric Inhibitor of MEK1/2 for the Treatment of CancerIVERSON, Cory; LARSON, Gary; HAMATAKE, Robert et al.Cancer research (Chicago, Ill.). 2009, Vol 69, Num 17, pp 6839-6847, issn 0008-5472, 9 p.Article

Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/CXCR2 non-competitive allosteric inhibitorBERTINI, R; BARCELOS, L. S; CORSI, M. M et al.British journal of pharmacology. 2012, Vol 165, Num 2, pp 436-454, issn 0007-1188, 19 p.Article

Insights into MAPK p38α DFG flip mechanism by accelerated molecular dynamicsFILOMIA, Federico; DE RIENZO, Francesca; MENZIANI, M. Cristina et al.Bioorganic & medicinal chemistry. 2010, Vol 18, Num 18, pp 6805-6812, issn 0968-0896, 8 p.Article

STRUCTURAL SPECIFICITY OF THE ALLOSTERIC INHIBITOR OF PHOSPHOENOLPYRUVATE CARBOXYLASE OF ESCHERICHIA COLI.YOSHINAGA T.1977; J. BIOCHEM.; JAP.; DA. 1977; VOL. 81; NO 3; PP. 665-671; BIBL. 17 REF.Article

Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055VENDEVILLE, Sandrine; LIN, Tse-I; DEVOGELAERE, Benoit et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 13, pp 4437-4443, issn 0960-894X, 7 p.Article

Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole seriesMCGOWAN, David; VENDEVILLE, Sandrine; DEHERTOGH, Pascale et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 13, pp 4431-4436, issn 0960-894X, 6 p.Article

A quantitative study of [³H]-D-Ala²-D-Leu⁵-enkephalin binding to rat brain membranes. Evidence that oxymorphone is a noncompetitive inhibitor of the lower affinity δ-binding siteROTHMAN, R. B; BOWEN, W. D; HERKENHAM, M et al.Molecular pharmacology. 1985, Vol 27, Num 3, pp 399-409, issn 0026-895XArticle

Fused thiophene derivatives as MEK inhibitorsLAING, Victoria E; BROOKINGS, Daniel C; MEIER, Christoph et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 1, pp 472-475, issn 0960-894X, 4 p.Article

INFLUENCE OF PHOSPHATE ON THE ALLOSTERIC BEHAVIOR OF YEAST PHOSPHOFRUCTOKINASE.LAURENT M; SEYDOUX F.1977; BIOCHEM. BIOPHYS. RES. COMMUNIC.; U.S.A.; DA. 1977; VOL. 78; NO 4; PP. 1289-1295; BIBL. 22 REF.Article

STOPPED FLOW FLUORESCENCE STUDIES ON THE BINDING OF REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE TO CITRATE SYNTHASE OF ESCHERICHIA COLI: EFFECTS OF PH.SADAR MH; QUEEN A; DUCKWORTH HW et al.1977; CANAD. J. BIOCHEM.; CANADA; DA. 1977; VOL. 55; NO 7; PP. 714-720; BIBL. 8 REF.Article

FLAVODOXIN: AN ALLOSTERIC INHIBITOR OF AMP NUCLEOSIDASE FROM AZOTOBACTER VINELANDII.YOSHINO M; MURAKAMI K; TSUSHIMA K et al.1976; J. BIOCHEM.; JAP.; DA. 1976; VOL. 80; NO 4; PP. 839-843; BIBL. 14 REF.Article

EFFECT OF SOME NUCLEOTIDES ON THE REGULATION OF GLYCOSAMINOGLYCAN BIOSYNTHESIS.DE LUCA G; SPEZIALE P; RINDI S et al.1976; CONNECT. TISSUE RES.; G.B.; DA. 1976; VOL. 4; NO 4; PP. 247-254; BIBL. 32 REF.Article

Identification of aspartic acid-203 in human thymidine phosphorylase as an important residue for both catalysis and non-competitive inhibition by the small molecule crystallization chaperone 5¹-O-tritylinosine (KIN59)BRONCKAERS, A; AGUADA, L; NEGRI, A et al.Biochemical pharmacology. 2009, Vol 78, Num 3, pp 231-240, issn 0006-2952, 10 p.Article

Arylamide derivatives as allosteric inhibitors of the integrin α₂β₁/type I collagen interactionHANG YIN; GERLACH, Lars Ole; MILLER, Meredith W et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 13, pp 3380-3382, issn 0960-894X, 3 p.Article

Inhibitors Targeting the LFA-1/ICAM-1 Cell-Adhesion Interaction : Design and Mechanism of ActionZIMMERMAN, Tahl; BLANCO, Francisco J.Current pharmaceutical design. 2008, Vol 14, Num 22, pp 2128-2139, issn 1381-6128, 12 p.Article

A Structure-Function Perspective of Jak2 Mutations and Implications for Alternate Drug Design Strategies: The Road not TakenGNANASAMBANDAN, K; SAYESKI, P. P.Current medicinal chemistry. 2011, Vol 18, Num 30, pp 4659-4673, issn 0929-8673, 15 p.Article

Preclinical Characterization of BMS-791325, an Allosteric Inhibitor of Hepatitis C Virus NS5B PolymeraseLEMM, Julie A; MENGPING LIU; KNIPE, Jay O et al.Antimicrobial agents and chemotherapy. 2014, Vol 58, Num 6, pp 3485-3495, issn 0066-4804, 11 p.Article

New Directions in Targeting Protein Kinases: Focusing Upon True Allosteric and Bivalent InhibitorsLAMBA, Vandana; GHOSH, Indraneel.Current pharmaceutical design (Print). 2012, Vol 18, Num 20, pp 2936-2945, issn 1381-6128, 10 p.Article

Matrix metalloproteinase inhibitors : New challenges in the era of post broad-spectrum inhibitorsNUTI, Elisa; TUCCINARDI, Tiziano; ROSSELLO, Armando et al.Current pharmaceutical design. 2007, Vol 13, Num 20, pp 2087-2100, issn 1381-6128, 14 p.Article

Phosphoenolpyruvate-insensitive phosphofructokinase isozyme from Thermus thermophilus HB8JING XU; OSHIMA, T; YOSHIDA, M et al.Journal of biochemistry (Tokyo). 1991, Vol 109, Num 2, pp 199-203, issn 0021-924X, 5 p.Article

The role of Glu187 in the regulation of phosphofructokinase by phosphoenolpyruvateAUZAT, I; LE BRAS, G; BRANNY, P et al.Journal of molecular biology. 1994, Vol 235, Num 1, pp 68-72, issn 0022-2836Article

Crystallographic binding studies on the allosteric inhibitor glucose-6-phosphate to T state glycogen phosphorylase bJOHNSON, L. N; SNAPE, P; MARTIN, J. L et al.Journal of molecular biology. 1993, Vol 232, Num 1, pp 253-267, issn 0022-2836Article

A general technique to rank protein-ligand binding affinities and determine allosteric versus direct binding site competition in compound mixturesANNIS, D. Allen; NAZEF, Naim; CHUANG, Cheng-Chi et al.Journal of the American Chemical Society. 2004, Vol 126, Num 47, pp 15495-15503, issn 0002-7863, 9 p.Article

Inhibition of hepatic tryptophan-2,3-dioxygenase : Superior potency of melatonin over serotoninWALSH, H. A; DAYA, S.Journal of pineal research. 1997, Vol 23, Num 1, pp 20-23, issn 0742-3098Article

Enhanced oxygenation in vivo by allosteric inhibitors of hemoglobin saturationKHANDELWAL, S. R; RANDAD, R. S; PECK-SUN LIN et al.American journal of physiology. Heart and circulatory physiology. 1993, Vol 34, Num 4, pp H1450-H1453, issn 0363-6135Article