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kw.\*:("Gene-Directed Enzyme Prodrug Therapy")

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Gene-directed enzyme prodrug therapy (GDEPT) : choice of prodrugsSPRINGER, C. J; NICULESCU-DUVAZ, I.Advanced drug delivery reviews. 1996, Vol 22, Num 3, pp 351-364, issn 0169-409XArticle

The design of selectively-activated anti-cancer prodrugs for use in antibody-directed and gene-directed enzyme-prodrug therapiesDENNY, W. A; WILSON, W. R.Journal of pharmacy and pharmacology. 1998, Vol 50, Num 4, pp 387-394, issn 0022-3573Conference Paper

The HIF-1-active microenvironment: An environmental target for cancer therapyKIZAKA-KONDOH, Shinae; TANAKA, Shotaro; HARADA, Hiroshi et al.Advanced drug delivery reviews. 2009, Vol 61, Num 7-8, pp 623-632, issn 0169-409X, 10 p.Article

Paclitaxel-2'-ethylcarbonate prodrug can circumvent P-glycoprotein-mediated cellular efflux to increase drug cytotoxicityTANINO, Tadatoshi; NAWA, Akihiro; ICHIDA, Seiji et al.Pharmaceutical research. 2007, Vol 24, Num 3, pp 555-565, issn 0724-8741, 11 p.Article

Tyrosinase mutants are capable of prodrug activation in transfected nonmelanotic cellsSIMONOVA, Maria; WALL, Alexander; WEISSLEDER, Ralph et al.Cancer research (Baltimore). 2000, Vol 60, Num 23, pp 6656-6662, issn 0008-5472Article

Potential Tumor-tropic Effect of Genetically Engineered Stem Cells Expressing Suicide Enzymes to Selectively Target Invasive Cancer in Animal ModelsKIM, Seung U; JEUNG, Eui-Bae; KIM, Yun-Bae et al.Anticancer research. 2011, Vol 31, Num 4, pp 1249-1258, issn 0250-7005, 10 p.Article

Prodrugs for Targeted Tumor Therapies: Recent Developments in ADEPT, GDEPT and PMTTIETZE, Lutz F; SCHMUCK, Kianga.Current pharmaceutical design (Print). 2011, Vol 17, Num 32, pp 3527-3547, issn 1381-6128, 21 p.Article

Recent Trends in Targeted Anticancer Prodrug and Conjugate DesignSINGH, Yashveer; PALOMBO, Matthew; SINKO, Patrick J et al.Current medicinal chemistry. 2008, Vol 15, Num 18, pp 1802-1826, issn 0929-8673, 25 p.Article

Gene regulation in cancer gene therapy strategiesSCANLON, Ian; LEHOURITIS, Panos; NICULESCU-DUVAZ, Ion et al.Current medicinal chemistry. 2003, Vol 10, Num 20, pp 2175-2184, issn 0929-8673, 10 p.Article

Nitroaryl phosphoramides as novel prodrugs for E. coli nitroreductase activation in enzyme prodrug therapyLONGQIN HU; CHENGZHI YU; YONGYING JIANG et al.Journal of medicinal chemistry (Print). 2003, Vol 46, Num 23, pp 4818-4821, issn 0022-2623, 4 p.Article

Crystal structure of FMN-dependent nitroreductase from Escherichia coli B: A prodrug-activating enzymePARKINSON, Gary N; SKELLY, Jane V; NEIDLE, Stephen et al.Journal of medicinal chemistry (Print). 2000, Vol 43, Num 20, pp 3624-3631, issn 0022-2623Article

Synthesis and evaluation of nitroheterocyclic carbamate prodrugs for use with nitroreductase-mediated gene-directed enzyme prodrug therapyHAY, Michael P; ANDERSON, Robert F; FERRY, Dianne M et al.Journal of medicinal chemistry (Print). 2003, Vol 46, Num 25, pp 5533-5545, issn 0022-2623, 13 p.Article

Cytochrome P450-Activated Prodrugs : Targeted Drug DeliveryHUTTUNEN, Kristiina M; MÄHÖNEN, Niina; RAUNIO, Hannu et al.Current medicinal chemistry. 2008, Vol 15, Num 23, pp 2346-2365, issn 0929-8673, 20 p.Article

Aziridinyldinitrobenzamides: Synthesis and structure-activity relationships for activation by E. coli nitroreductaseHELSBY, Nuala A; ATWELL, Graham J; SHANGJIN YANG et al.Journal of medicinal chemistry (Print). 2004, Vol 47, Num 12, pp 3295-3307, issn 0022-2623, 13 p.Article

Self-immolative nitrogen mustards prodrugs cleavable by carboxypeptidase G2 (CPG2) showing large cytotoxicity differentials in GDEPTNICULESCU-DUVAZ, Dan; NICULESCU-DUVAZ, Ion; FRIEDLOS, Frank et al.Journal of medicinal chemistry (Print). 2003, Vol 46, Num 9, pp 1690-1705, issn 0022-2623, 16 p.Article

Prodrug strategies in cancer therapyDENNY, William A.European journal of medicinal chemistry. 2001, Vol 36, Num 7-8, pp 577-595, issn 0223-5234Article

Synthesis and structure-activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugsLONGQIN HU; XINGHUA WU; KNOX, Richard J et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 13, pp 3986-3991, issn 0960-894X, 6 p.Article

Nitrobenzylcarbamate prodrugs of cytotoxic acridines for potential use with nitroreductase gene-directed enzyme prodrug therapyASCHE, Christian; DUMY, Pascal; CARREZ, Danièle et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 7, pp 1990-1994, issn 0960-894X, 5 p.Article

Yeast cytosine deaminase improves radiosensitization and bystander effect by 5-fluorocytosine of human colorectal cancer xenograftsKIEVIT, Els; NYATI, Mukesh K; NG, Emily et al.Cancer research (Baltimore). 2000, Vol 60, Num 23, pp 6649-6655, issn 0008-5472Article

Gene-directed enzyme prodrug therapy with a mustard prodrug/carboxypeptidase G2 combinationMARAIS, R; SPOONER, R. A; LIGHT, Y et al.Cancer research (Baltimore). 1996, Vol 56, Num 20, pp 4735-4742, issn 0008-5472Article

Nitroarylmethylcarbamate prodrugs of doxorubicin for use with nitroreductase gene-directed enzyme prodrug therapyHAY, Michael P; WILSON, William R; DENNY, William A et al.Bioorganic & medicinal chemistry. 2005, Vol 13, Num 12, pp 4043-4055, issn 0968-0896, 13 p.Article

Structure-activity relationships for 4-nitrobenzyl carbamates of 5-aminobenz[e]indoline minor groove alkylating agents as prodrugs for GDEPT in conjunction with E. coli nitroreductaseHAY, Michael P; ATWELL, Graham J; WILSON, William R et al.Journal of medicinal chemistry (Print). 2003, Vol 46, Num 12, pp 2456-2466, issn 0022-2623, 11 p.Article

Nitrobenzyl carbamate prodrugs of enediynes for nitroreductase gene-directed enzyme prodrug therapy (GDEPT)HAY, M. P; WILSON, W. R; DENNY, W. A et al.Bioorganic & medicinal chemistry letters (Print). 1999, Vol 9, Num 24, pp 3417-3422, issn 0960-894XArticle

Self-immolative anthracycline prodrugs for suicide gene therapyNICULESCU-DUVAZ, I; NICULESCU-DUVAZ, D; FRIEDLOS, F et al.Journal of medicinal chemistry (Print). 1999, Vol 42, Num 13, pp 2485-2489, issn 0022-2623Article

Significant differences in biological parameters between prodrugs cleavable by carboxypeptidase G2 that generate 3,5-difluoro-phenol and -aniline nitrogen mustards in gene-directed enzyme prodrug therapy systemsNICULESCU-DUVAZ, I; SCANLON, I; NICULESCU-DUVAZ, D et al.Journal of medicinal chemistry (Print). 2004, Vol 47, Num 10, pp 2651-2658, issn 0022-2623, 8 p.Article

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