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In Silico Identification of Significant Detrimental Missense Mutations of EGFR and Their Effect with 4-Anilinoquinazoline-Based DrugsRAJASEKARAN, R; SETHUMADHAVAN, Rao.Applied biochemistry and biotechnology. 2010, Vol 160, Num 6, pp 1723-1733, issn 0273-2289, 11 p.Article

Synergistic proapoptotic effects of the two tyrosine kinase inhibitors pazopanib and lapatinib on multiple carcinoma cell linesOLAUSSEN, K. A; COMMO, F; KROEMER, G et al.Oncogene (Basingstoke). 2009, Vol 28, Num 48, pp 4249-4260, issn 0950-9232, 12 p.Article

Successful Treatment of HER-2-Positive Metastatic Apocrine Carcinoma of the Skin with Lapatinib and CapecitabineHIDAKA, Takanori; FUJIMURA, Taku; WATABE, Akiko et al.Acta dermato-venereologica. 2012, Vol 92, Num 6, pp 654-655, issn 0001-5555, 2 p.Article

FLUORESCENCE IN SITU HYBRIDIZATION GENE AMPLIFICATION ANALYSIS OF EGFR AND HER2 IN PATIENTS WITH MALIGNANT SALIVARY GLAND TUMORS TREATED WITH LAPATINIBVIDAL, Laura; TSAO, Ming S; HAYES, D. Neil et al.Head & neck. 2009, Vol 31, Num 8, pp 1006-1012, issn 1043-3074, 7 p.Article

Trastuzumab et lapatinib dans la prise en charge du cancer du sein HER2 positif = Trastuzumab and lapatinib for the management of the HER2-positive breast cancerGUIU, S; ADOUBI, I; KOUASSI COMOE, J. C et al.Journal africain du cancer (Print). 2011, Vol 3, Num 2, pp 128-140, issn 1965-0817, 13 p.Article

Hepatotoxicity associated with lapatinib in an experimental rat modelDEMIRCI, Umut; BUYUKBERBER, Suleyman; YILMAZ, Guldal et al.European journal of cancer (1990). 2012, Vol 48, Num 2, pp 279-285, issn 0959-8049, 7 p.Article

Activation of the neuregulin/ErbB system during physiological ventricular remodeling in pregnancyLEMMENS, Katrien; DOGGEN, Kris; DE KEULENAER, Gilles W et al.American journal of physiology. Heart and circulatory physiology. 2011, Vol 69, Num 3, issn 0363-6135, H931-H942Article

Determination of lapatinib (GW572016) in human plasma by liquid chromatography electrospray tandem mass spectrometry (LC-ESI-MS/MS)FENG BAI; FREEMAN, Burgess B; FRAGA, Charles H et al.Journal of chromatography. B. 2006, Vol 831, Num 1-2, pp 169-175, issn 1570-0232, 7 p.Article

Electrophysiological Effects of the Anti-Cancer Drug Lapatinib on Cardiac RepolarizationLEE, Hyang-Ae; KIM, Eun-Joo; HYUN, Sung-Ae et al.Basic & clinical pharmacology & toxicology (Print). 2010, Vol 107, Num 1, pp 614-618, issn 1742-7835, 5 p.Article

The Role of Efflux and Uptake Transporters in N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine (GW572016, Lapatinib) Disposition and Drug InteractionsPOLLI, Joseph W; HUMPHREYS, Joan E; HARMON, Kelly A et al.Drug metabolism and disposition. 2008, Vol 36, Num 4, pp 695-701, issn 0090-9556, 7 p.Article

Metabolic Intermediate Complex Formation of Human Cytochrome P450 3A4 by LapatinibTAKAKUSA, Hideo; WAHLIN, Michelle D; CHUNSHENG ZHAO et al.Drug metabolism and disposition. 2011, Vol 39, Num 6, pp 1022-1030, issn 0090-9556, 9 p.Article

Lapatinib plus capecitabine for HER2-positive advanced breast cancerGEYER, Charles E; FORSTER, John; SKARLOS, Dimosthenis et al.The New England journal of medicine. 2006, Vol 355, Num 26, pp 2733-2743, issn 0028-4793, 11 p.Article

A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): Relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cellsWOOD, Edgar R; TRUESDALE, Anne T; ALLIGOOD, Krystal J et al.Cancer research (Baltimore). 2004, Vol 64, Num 18, pp 6652-6659, issn 0008-5472, 8 p.Article

Effects of Food on the Relative Bioavailability of Lapatinib in Cancer PatientsKOCH, Kevin M; REDDY, Nandi J; COHEN, Roger B et al.Journal of clinical oncology. 2009, Vol 27, Num 8, pp 1191-1196, issn 0732-183X, 6 p.Article

Cardiac Safety of Lapatinib : Pooled Analysis of 3689 Patients Enrolled in Clinical TrialsPEREZ, Edith A; KOEHLER, Maria; BYRNE, Julie et al.Mayo Clinic proceedings. 2008, Vol 83, Num 6, pp 679-686, issn 0025-6196, 8 p.Article

A first synthesis of 18F-radiolabeled lapatinib: a potential tracer for positron emission tomographic imaging of ErbB1/ErbB2 tyrosine kinase activityBASULI, Falguni; HAITAO WU; CHANGHUI LI et al.Journal of labelled compounds & radiopharmaceuticals. 2011, Vol 54, Num 9-10, pp 633-636, issn 0362-4803, 4 p.Article

LAPATINIB IN COMBINATION WITH RADIATION DIMINISHES TUMOR REGROWTH IN HER2+ AND BASAL-LIKE/EGFR+ BREAST TUMOR XENOGRAFTSSAMBADE, Maria J; KIMPLE, Randall J; TERESE CAMP, J. Terese et al.International journal of radiation oncology, biology, physics. 2010, Vol 77, Num 2, pp 575-581, issn 0360-3016, 7 p.Article

Hepatotoxicity of Tyrosine Kinase Inhibitors: Clinical and Regulatory PerspectivesSHAH, Rashmi R; MORGANROTH, Joel; SHAH, Devron R et al.Drug safety. 2013, Vol 36, Num 7, pp 491-503, issn 0114-5916, 13 p.Article

Study of the biologic effects of lapatinib, a reversible inhibitor of ErbB1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignanciesSPECTOR, Neil L; WENLE XIA; SMITH, Deborah A et al.Journal of clinical oncology. 2005, Vol 23, Num 11, pp 2502-2512, issn 0732-183X, 11 p.Conference Paper

Phase 1 study of pazopanib alone or combined with lapatinib in Japanese patients with solid tumorsMEGUMI, Inada-Inoue; ANDO, Yuichi; MIZUNO, Keiko et al.Cancer chemotherapy and pharmacology. 2014, Vol 73, Num 4, pp 673-683, issn 0344-5704, 11 p.Article

Resistance to HER2 inhibitors: Is addition better than substitution? Rationale for the hypothetical concept of drug sedimentationCAMPONE, Mario; JUIN, Philippe; ANDRE, Fabrice et al.Critical reviews in oncology/hematology. 2011, Vol 78, Num 3, pp 195-205, issn 1040-8428, 11 p.Article

Lapatinib in breast cancerBILANCIA, D; ROSATI, G; DINOTA, A et al.Annals of oncology. 2007, Vol 18, issn 0923-7534, vi26-vi30, SUP6Conference Paper

Cancer du sein HER2+ adjuvant: Trastuzumab, lapatinib ou les deux ?LAUNAY-VACHER, Vincent.Onko +. 2014, Vol 6, Num 48, pp 126-127, issn 2101-9495, 2 p.Article

Effect of CYP3A4 inducer dexamethasone on hepatotoxicity of lapatinib: clinical and in vitro evidenceYI LING TEO; SAETAEW, Manit; CHANTHAWONG, Suthan et al.Breast cancer research and treatment. 2012, Vol 133, Num 2, pp 703-711, issn 0167-6806, 9 p.Article

Lapatinib, trastuzumab or the combination added to preoperative chemotherapy for breast cancer: a meta-analysis of randomized evidenceVALACHIS, Antonis; NEARCHOU, Andreas; LIND, Pehr et al.Breast cancer research and treatment. 2012, Vol 135, Num 3, pp 655-662, issn 0167-6806, 8 p.Article

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