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Results 1 to 25 of 753

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APP processing enzymes (secretases) as therapeutic targets: Insights from the use of transgenics (Tgs) and transfected cells : Application of genetically altered mice models and their significance in neurodegenerative diseaseMARKS, Neville; BERG, Martin J.Neurochemical research. 2003, Vol 28, Num 7, pp 1049-1062, issn 0364-3190, 14 p.Article

Association of Omi/HtrA2 with γ-secretase in mitochondriaBEHBAHANI, Homira; PAVLOV, Pavel F; WIEHAGER, Birgitta et al.Neurochemistry international. 2010, Vol 57, Num 6, pp 668-675, issn 0197-0186, 8 p.Article

Presenilin diversifies its portfolioPARKS, Annette L; CURTIS, Daniel.Trends in genetics (Regular ed.). 2007, Vol 23, Num 3, pp 140-150, issn 0168-9525, 11 p.Article

Presenilin-null cells have altered two-pore calcium channel expression and lysosomal calcium: Implications for lysosomal functionNEELY KAYALA, Kara M; DICKINSON, George D; MINASSIAN, Anet et al.Brain research. 2012, Vol 1489, pp 8-16, issn 0006-8993, 9 p.Article

Interference with splicing of Presenilin transcripts has potent dominant negative effects on Presenilin activityNORNES, Svanhild; NEWMAN, Morgan; VERDILE, Giuseppe et al.Human molecular genetics (Print). 2008, Vol 17, Num 3, pp 402-412, issn 0964-6906, 11 p.Article

Analysis of transcriptional modulation of the presenilin 1 gene promoter by ZNF237, a candidate binding partner of the Ets transcription factor ERMPASTORCIC, Martine; DAS, Hriday K.Brain research. 2007, Vol 1128, pp 21-32, issn 0006-8993, 12 p.Article

Presenilin 1 Glu318Gly polymorphism : Interpret with cautionGOLDMAN, Jill S; JOHNSON, Julene K; MCELLIGOTT, Karen et al.Archives of neurology (Chicago). 2005, Vol 62, Num 10, pp 1624-1627, issn 0003-9942, 4 p.Article

GPI-1046 Increases Presenilin-1 Expression and Restores NMDA Channel ActivitySTEINER, Joseph P; PAYNE, Kathryn B; DRUMMOND MAIN, Christopher et al.Canadian journal of neurological sciences. 2010, Vol 37, Num 4, pp 457-467, issn 0317-1671, 11 p.Article

Presenilin-1 is indirectly implicated in Notchl cleavageGODIN, Chantal; AUCLAIR, Annie; FERLAND, Mélissa et al.Neuroreport (Oxford). 2003, Vol 14, Num 12, pp 1613-1616, issn 0959-4965, 4 p.Article

Atypical dementia associated with a novel presenilin-2 mutationBINETTI, Giuliano; SIGNORINI, Simona; TESTA, Cristina et al.Annals of neurology. 2003, Vol 54, Num 6, pp 832-836, issn 0364-5134, 5 p.Article

Changes in Presenilin 1 gene methylation pattern in diet-induced B vitamin deficiencyFUSO, Andrea; NICOLIA, Vincenzina; PASQUALATO, Alessia et al.Neurobiology of aging. 2011, Vol 32, Num 2, pp 187-199, issn 0197-4580, 13 p.Article

Frontotemporal dementia and parkinsonism associated with the IVSI+IG→A mutation in progranulin : a clinicopathologic studyGOEDERT, Michel; GRAZIA SPILLANTINI, Maria; RADEMAKERS, Rosa et al.Brain. 2006, Vol 129, issn 0006-8950, 2808-2810,3103-3114 [15 p.], 11Article

Inhibition of angiogenesis and tumor growth by β and γ-secretase inhibitorsPARIS, Daniel; QUADROS, Amita; PATEL, Nikunj et al.European journal of pharmacology. 2005, Vol 514, Num 1, pp 1-15, issn 0014-2999, 15 p.Article

Enrichment of Presenilin 1 peptides in neuronal large dense-core and somatodendritic clathrin-coated vesiclesEFTHIMIOPOULOS, S; FLOOR, E; GEORGAKOPOULOS, A et al.Journal of neurochemistry. 1998, Vol 71, Num 6, pp 2365-2372, issn 0022-3042Article

Analysis of notch function in presomitic mesoderm suggests a γ-secretase-independent role for presenilins in somite differentiationHUPPERT, Stacey S; ILAGAN, Ma. Xenia G; DE STROOPER, Bart et al.Developmental cell. 2005, Vol 8, Num 5, pp 677-688, issn 1534-5807, 12 p.Article

A presenilin 1 R278I mutation presenting with language impairmentGODBOLT, A. K; BECK, J. A; COLLINGE, J et al.Neurology. 2004, Vol 63, Num 9, pp 1702-1704, issn 0028-3878, 3 p.Article

Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilinCHIANG, Po-Min; FORTNA, RyanR; PRICE, DonaldL et al.Neurobiology of aging. 2012, Vol 33, Num 2, pp 277-285, issn 0197-4580, 9 p.Article

Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific y secretaseJANKOWSKY, Joanna L; FADALE, Daniel J; YOUNKIN, Steven G et al.Human molecular genetics (Print). 2004, Vol 13, Num 2, pp 159-170, issn 0964-6906, 12 p.Article

Neuropsychological function in nondemented carriers of presenilin-1 mutationsRINGMAN, J. M; DIAZ-OLAVARRIETA, C; GHETTI, B et al.Neurology. 2005, Vol 65, Num 4, pp 552-558, issn 0028-3878, 7 p.Article

Decrease in NF-κB, AP-I and SP-I activities in neuronal cells expressing presenilin 2HONG NGA NGUYEN; SUN YOUNG LEE; HWANG, Daeyoun et al.Neuroreport (Oxford). 2005, Vol 16, Num 7, pp 731-735, issn 0959-4965, 5 p.Article

Inhibition of basal activity of c-jun-NH2-terminal kinase (JNK) represses the expression of presenilin-1 by a p53-dependent mechanismLEE, Sebum; DAS, Hriday K.Brain research. 2008, Vol 1207, pp 19-31, issn 0006-8993, 13 p.Article

Calcium oscillations in type-1 astrocytes, the effect of a presenilin 1 (PS1) mutationJOHNSTON, Jane M; BURNETT, Paul; THOMAS, Andrew P et al.Neuroscience letters. 2006, Vol 395, Num 2, pp 159-164, issn 0304-3940, 6 p.Article

Ets transcription factors ER81 and Elk1 regulate the transcription of the human presenilin 1 gene promoterPASTORCIC, Martine; DAS, Hriday K.Molecular brain research. 2003, Vol 113, Num 1-2, pp 57-66, issn 0169-328X, 10 p.Article

Developing Preventive Therapies for Chronic Diseases : Lessons Learned from Alzheimer's DiseaseSELKOE, Dennis J.Nutrition reviews. 2007, Vol 65, Num 12, issn 0029-6643, S239-S243, 2Conference Paper

Dementia, pyramidal system involvement, and leukoencephalopathy with a presenilin 1 mutationMARROSU, M. G; FLORIS, G; COSTA, G et al.Neurology. 2005, Vol 66, Num 1, pp 108-111, issn 0028-3878, 4 p.Article

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