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Results 1 to 25 of 819

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Screening of 64 Tryptamines at NMDA, 5-HT1A, and 5-HT2A Receptors: A Comparative Binding and Modeling StudyBERGER, M. L; PALANGSUNTIKUL, R; REBERNIK, P et al.Current medicinal chemistry. 2012, Vol 19, Num 18, pp 3044-3057, issn 0929-8673, 14 p.Article

Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulatorsMONAGHAN, Daniel T; IRVINE, Mark W; MATHIAS COSTA, Blaise et al.Neurochemistry international. 2012, Vol 61, Num 4, pp 581-592, issn 0197-0186, 12 p.Article

Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-methyl-D-aspartate receptorsIRVINE, Mark W; COSTA, Blaise M; VOLIANSKIS, Arturas et al.Neurochemistry international. 2012, Vol 61, Num 4, pp 593-600, issn 0197-0186, 8 p.Article

Glutamate Transporter 1: Target for the Treatment of Alcohol DependenceRAO, P. S. S; SARI, Y.Current medicinal chemistry. 2012, Vol 19, Num 30, pp 5148-5156, issn 0929-8673, 9 p.Conference Paper

Design and synthesis of substituted N-(1,3-diphenyl-1H-pyrazol-5-yl)-benzamides as positive allosteric modulators of the metabotropic glutamate receptor subtype 5ZOU, Mu-Fa; JIANJINGCAO; RODRIGUEZ, Alice L et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 9, pp 2650-2654, issn 0960-894X, 5 p.Article

New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): Identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolonesTRABANCO, Andrés A; DUVEY, Guillaume; LAVREYSEN, Hilde et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 3, pp 971-976, issn 0960-894X, 6 p.Article

Synthesis of 4-(aminoalkyl) substituted 1,3-dioxanes as potent NMDA and σ receptor antagonistsUTECH, Tina; KÖHLER, Jens; WÜNSCH, Bernhard et al.European journal of medicinal chemistry. 2011, Vol 46, Num 6, pp 2157-2169, issn 0223-5234, 13 p.Article

Discovery of molecular switches within the ADX-47273 mGlu5 PAM scaffold that modulate modes of pharmacology to afford potent mGlu5 NAMs, PAMs and partial antagonistsLAMB, Jeffrey P; ENGERS, Darren W; NISWENDERA, Colleen M et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 9, pp 2711-2714, issn 0960-894X, 4 p.Article

Potent mGluR5 antagonists: Pyridyl and thiazolyl-ethynyl-3,5-disubstituted-phenyl seriesALAGILLE, David; DACOSTA, Herve; CHEN, Yelin et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 11, pp 3243-3247, issn 0960-894X, 5 p.Article

Aromatic L-amino acid decarboxylase phosphorylation and activation by PKGIα in vitroDUCHEMIN, Anne-Marie; NEFF, Norton H; HADJICONSTANTINOU, Maria et al.Journal of neurochemistry. 2010, Vol 114, Num 2, pp 542-552, issn 0022-3042, 11 p.Article

Hit-to-lead optimization of disubstituted oxadiazoles and tetrazoles as mGluRS NAMsWAGNER, Gábor; WEBER, Csaba; NAGY, József et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 12, pp 3737-3741, issn 0960-894X, 5 p.Article

Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving miceKÄENMÄKI, Mikko; TAMMIMÄKI, Anne; MYÖHÄNEN, Timo et al.Journal of neurochemistry. 2010, Vol 114, Num 6, pp 1745-1755, issn 0022-3042, 11 p.Article

A novel series of positive modulators of the AMPA receptor: Structure-based lead optimizationJAMIESON, Craig; CAMPBELL, Robert A; MARTIN, Frederic et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 20, pp 6072-6075, issn 0960-894X, 4 p.Article

N-Substituted pyrrolidines and tetrahydrofurans as novel AMPAR positive modulatorsTHEWLIS, Kevin M; ALDEGHERI, Laura; HARRIES, Mark H et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 23, pp 7116-7119, issn 0960-894X, 4 p.Article

Discovery of a potent and brain penetrant mGluRS positive allosteric modulatorRITZEN, Andreas; SINDET, Rikke; HENTZER, Morten et al.Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 12, pp 3275-3278, issn 0960-894X, 4 p.Article

Mechanism of okadaic acid-induced neuronal death and the effect of estrogensKUN DON YI; COVEY, Douglas F; SIMPKINS, James W et al.Journal of neurochemistry. 2009, Vol 108, Num 3, pp 732-740, issn 0022-3042, 9 p.Article

Structure―Activity Relationships Comparing N-(6-Methylpyridin-yl)-Substituted Aryl Amides to 2-Methyl-6-(substituted-arylethynyl)pyridines or 2-Methyl-4-(substituted-arylethynyl)thiazoles as Novel Metabotropic Glutamate Receptor Subtype 5 AntagonistsKULKARNI, Santosh S; ZOU, Mu-Fa; JIANJING CAO et al.Journal of medicinal chemistry (Print). 2009, Vol 52, Num 11, pp 3563-3575, issn 0022-2623, 13 p.Article

Synthesis and evaluation of novel tricyclic benzo[4.5]cyclohepta[1.2]pyridine derivatives as NMDA/NR2B antagonistsMCINTYRE, Charles J; MCCAULEY, John A; KOBLAN, Ken S et al.Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 17, pp 5132-5135, issn 0960-894X, 4 p.Article

Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)aminesDUQUE, Maria D; CAMPS, Pelayo; RADHIKA PRATHALINGAM, S et al.Bioorganic & medicinal chemistry. 2009, Vol 17, Num 8, pp 3198-3206, issn 0968-0896, 9 p.Article

The discovery of a structurally novel class of inhibitors of the type 1 glycine transporterLOWE, John A; XINJUN HOU; TUNUCCI, Don et al.Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 11, pp 2974-2976, issn 0960-894X, 3 p.Article

Hydroxamic Acids As a Novel Family of Serine Racemase Inhibitors: Mechanistic Analysis Reveals Different Modes of Interaction with the Pyridoxal-5'-phosphate CofactorHOFFMAN, Hillary E; JIRASKOVA, Jana; CIGLER, Petr et al.Journal of medicinal chemistry (Print). 2009, Vol 52, Num 19, pp 6032-6041, issn 0022-2623, 10 p.Article

Discovery and biological profile of isoindolinone derivatives as novel metabotropic glutamate receptor 1 antagonists: A potential treatment for psychotic disordersITO, Satoru; HIRATA, Yukari; OHTA, Hisashi et al.Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 18, pp 5310-5313, issn 0960-894X, 4 p.Article

Discovery and in vitro and in vivo profiles of 4-fluoro-N-[4-[6-(isopropylamino) pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide as novel class of an orally active metabotropic glutamate receptor 1 (mGluR1) antagonistSATOH, Atsushi; NAGATOMI, Yasushi; OHTA, Hisashi et al.Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 18, pp 5464-5468, issn 0960-894X, 5 p.Article

3D-QSAR studies of triazafluorenone inhibitors of metabotropic glutamate receptor subtype 1NATARAJA SEKHAR, Y; RAVIKUMAR, Muttineni; RAVI SHASHI NAYANA, M et al.European journal of medicinal chemistry. 2008, Vol 43, Num 5, pp 1025-1034, issn 0223-5234, 10 p.Article

Structures of the Ligand-Binding Core of iGluR2 in Complex with the Agonists (R)-and (S)-2-Amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic Acid Explain Their Unusual EquipotencyBEICH-FRANDSEN, Mads; PICKETING, Darryl S; MIRZA, Osman et al.Journal of medicinal chemistry (Print). 2008, Vol 51, Num 5, pp 1459-1463, issn 0022-2623, 5 p.Article

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