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Results 1 to 25 of 19246

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Treating blood pressure between 140/90 and 160/95 mmHg: no proven benefitPrescrire international (Paris). 2014, Vol 23, Num 148, issn 1167-7422, p. 106Article

Efficacy and Effects on Lipid Metabolism of Combination Treatment With Losartan + Hydrochlorothiazide Versus Losartan + Amlodipine: A 48-Week Prospective, Multicenter, Randomized, Open-Label TrialNISHIWAKI, Masato; HOSOAI, Hiroshi; YOKOYAMA, Masako et al.Clinical therapeutics. 2013, Vol 35, Num 4, pp 461-473, issn 0149-2918, 13 p.Article

Design and synthesis of potent, isoxazole-containing renin inhibitorsFOURNIER, Pierre-André; ARBOUR, Melissa; HOULE, Robert et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 8, pp 2670-2674, issn 0960-894X, 5 p.Article

Telmisartan: A Review of its Use in Cardiovascular Disease PreventionFRAMPTON, James E.Drugs (Basel). 2011, Vol 71, Num 6, pp 651-677, issn 0012-6667, 27 p.Article

Angiotensin-I-converting enzyme inhibitory peptides: Chemical feature based pharmacophore generationZHANLI WANG; SAISAI ZHANG; HONGWEI JIN et al.European journal of medicinal chemistry. 2011, Vol 46, Num 8, pp 3428-3433, issn 0223-5234, 6 p.Article

Impact of passive permeability and gut efflux transport on the oral bioavailability of novel series of piperidine-based renin inhibitors in rodentsLEVESQUE, Jean-François; BLEASBY, Kelly; HAFEY, Michael et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 18, pp 5547-5551, issn 0960-894X, 5 p.Article

Renin inhibitors for the treatment of hypertension: Design and optimization of a novel series of spirocyclic piperidinesCHEN, Austin; ASPIOTIS, Renee; LALIBERTE, Sébastien et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 24, pp 7399-7404, issn 0960-894X, 6 p.Article

Synthesis, biological evaluation and docking studies of octane-carboxamide based renin inhibitors with extended segments toward S3' site of reninYONG WU; CHEN SHI; XIAOWEI SUN et al.Bioorganic & medicinal chemistry. 2011, Vol 19, Num 14, pp 4238-4249, issn 0968-0896, 12 p.Article

Antihypertensive activity of newer 1,4-dihydro-5-pyrimidine carboxamides: Synthesis and pharmacological evaluationALAM, Ozair; KHAN, Suroor A; SIDDIQUI, Nadeem et al.European journal of medicinal chemistry. 2010, Vol 45, Num 11, pp 5113-5119, issn 0223-5234, 7 p.Article

ACE inhibitors hypothesis generation for selective design, synthesis and biological evaluation of 3-mercapto-2-methyl-propanoyl-pyrrolidine-3-imine derivatives as antihypertensive agentsISMAIL, Mohamed A. H; NABIL ABOUL-ENEIN, M; ABOUZID, Khaled A. M et al.Bioorganic & medicinal chemistry. 2009, Vol 17, Num 10, pp 3739-3746, issn 0968-0896, 8 p.Article

Discovery of 3,3-disubstituted piperidine-derived trisubstituted ureas as highly potent soluble epoxide hydrolase inhibitorsSHEN, Hong C; DING, Fa-Xiang; PAI, Lee-Yuh et al.Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 18, pp 5314-5320, issn 0960-894X, 7 p.Article

New classes of potent and bioavailable human renin inhibitorsREMEN, L'uboš; BEZENCON, Olivier; HESS, Patrick et al.Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 23, pp 6762-6765, issn 0960-894X, 4 p.Article

Effect of Drugs on Defibrillation CapacityLEGREID DOPP, Anna; MILLER, John M; TISDAIE, James E et al.Drugs (Basel). 2008, Vol 68, Num 5, pp 607-630, issn 0012-6667, 24 p.Article

Potent, Selective and Orally Bioavailable Dihydropyrimidine Inhibitors of Rho Kinase (ROCK1) as Potential Therapeutic Agents for Cardiovascular DiseasesSEHON, Clark A; WANG, Gren Z; DUL, Edward et al.Journal of medicinal chemistry (Print). 2008, Vol 51, Num 21, pp 6631-6634, issn 0022-2623, 4 p.Article

Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitorsHOLSWORTH, Daniel D; JALAIE, Mehran; MOCHALKIN, Igor et al.Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 13, pp 3575-3580, issn 0960-894X, 6 p.Article

Nifedipine-sensitive noradrenergic vasoconstriction is enhanced in spontaneously hypertensive rats : the influence of chronic captopril treatmentPAULIS, L; LISKOVA, S; PINTEROVA, M et al.Acta physiologica (Print). 2007, Vol 191, Num 4, pp 255-266, issn 1748-1708, 12 p.Article

Novel 2,7-dialkyl-substituted 5 (S ) -amino -4 (S ) -hydroxy -8 -phenyl -octanecarboxamide transition state peptidomimetics are potent and orally active inhibitors of human reninGOSCHKE, Richard; STUTZ, Stefan; GRUETTER, Markus G et al.Journal of medicinal chemistry (Print). 2007, Vol 50, Num 20, pp 4818-4831, issn 0022-2623, 14 p.Article

Synthesis of novel keto-ACE analogues as domain-selective angiotensin I-converting enzyme inhibitorsNCHINDA, Aloysius T; CHIBALE, Kelly; REDELINGHUYS, Pierre et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 17, pp 4612-4615, issn 0960-894X, 4 p.Article

Hypertension artérielle : Traitement antihypertenseur: quelle pression cible et pour qui ? = Antihypertensive therapy : who should be treated and to which target?WAEBER, B; BURNIER, M.Revue médicale suisse. 2006, Vol 2, Num 48, pp 123-127, issn 1660-9379, 4 p.Article

Improvement of ACE inhibitory activity of chitooligosaccharides (COS) by carboxyl modificationRONGHUA HUANG; MENDIS, Eresha; KIM, Se-Kwon et al.Bioorganic & medicinal chemistry. 2005, Vol 13, Num 11, pp 3649-3655, issn 0968-0896, 7 p.Article

Persistence with antihypertensives related to formulation : The case of nifedipineBREEKVELDT-POSTMA, Nancy S; HERINGS, Ron M. C.The Annals of pharmacotherapy. 2005, Vol 39, Num 2, pp 237-242, issn 1060-0280, 6 p.Article

Vasopeptidase inhibition for blood pressure control : Emerging experience : Perspectives of new antihypertensive drugsQUASCHNING, Thomas.Current pharmaceutical design. 2005, Vol 11, Num 25, pp 3293-3299, issn 1381-6128, 7 p.Article

Nébivolol (Nebilox, Temerit) : 15e bêtabloquant pour l'HTA, sans avantage pour les patients : Assez ! = Nebivolol (Nebilox, Temerit): 15th beta-blocker for essential arterial hypertension, without advantage for patients: stop!La Revue Prescrire. 2005, Vol 25, Num 257, pp 5-8, issn 0247-7750, 4 p.Article

Benzyl ether structure-activity relationships in a series of ketopiperazine-based renin inhibitorsPOWELL, Noel A; CLAY, Emma H; HOLSWORTH, Daniel D et al.Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 21, pp 4713-4716, issn 0960-894X, 4 p.Article

Dose-related efficacy of irbesartan in patients with mild-to-moderate essential hypertensionGRIMBERT, Philippe; GRENIER, Olivier; THUILLEZ, Christian et al.Thérapie (Paris). 2005, Vol 60, Num 6, pp 577-582, issn 0040-5957, 6 p.Article

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