GABA_A Receptor Subtype-Selective Efficacy : TPA023, an a2/a3 Selective Non-sedating Anxiolytic and α5IA, an α5 Selective Cognition EnhancerATACK, John R.CNS neuroscience & therapeutics (Print). 2008, Vol 14, Num 1, pp 25-35, issn 1755-5930, 11 p.Article

Inositol monophosphatase activity in normal, Down syndrome and dementia of the Alzheimer type CSFATACK, John R; SCHAPIRO, Mark B.Neurobiology of aging. 2002, Vol 23, Num 3, pp 389-396, issn 0197-4580Article

The complexity of the GABA_A receptor shapes unique pharmacological profilesD'HULST, Charlotte; ATACK, John R; KOOY, R. Frank et al.Drug discovery today. 2009, Vol 14, Num 17-18, pp 866-875, issn 1359-6446, 10 p.Article

Selective labelling of diazepam-insensitive GABA_A receptors in vivo using [³H]Ro 15-4513PYM, Luanda J; COOK, Susan M; ROSAHL, Thomas et al.British journal of pharmacology. 2005, Vol 146, Num 6, pp 817-825, issn 0007-1188, 9 p.Article

Contribution of GABA_A receptors containing α3 subunits to the therapeutic-related and side effects of benzodiazepine-type drugs in monkeysFISCHER, Bradford D; ATACK, John R; PLATT, Donna M et al.Psychopharmacologia. 2011, Vol 215, Num 2, pp 311-319, issn 0033-3158, 9 p.Article

2,3,7-trisubstituted pyrazolo[1,5-d][1,2,4]triazines : Functionally selective GABA_A α3-subtype agonistsCARLING, Robert W; RUSSELL, Michael G. N; MOORE, Kevin W et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 13, pp 3550-3554, issn 0960-894X, 5 p.Article

Discovery of functionally selective 7,8,9,10-tetrahydro-7,10-ethano-1,2,4-triazolo[3,4-a ]phthalazines as GABA_A receptor agonists at the α₃ subunitRUSSELL, Michael G. N; CARLING, Robert W; MOORE, Kevin W et al.Journal of medicinal chemistry (Print). 2005, Vol 48, Num 5, pp 1367-1383, issn 0022-2623, 17 p.Article

6,7-Dihydro-2-benzothiophen-4(5H)-ones: A novel class of GABA-A α5 receptor inverse agonistsCHAMBERS, Mark S; ATACK, John R; WAFFORD, Keith et al.Journal of medicinal chemistry (Print). 2002, Vol 45, Num 6, pp 1176-1179, issn 0022-2623Article

Reinforcing Effects Of Compounds Lacking Intrinsic Efficacy At αI Subunit-Containing GABA_A Receptor Subtypes in Midazolam- But Not Cocaine-Experienced Rhesus MonkeysSHINDAY, Nina M; SAWYER, Eileen K; FISCHER, Bradford D et al.Neuropsychopharmacology (New York, NY). 2013, Vol 38, Num 6, pp 1006-1014, issn 0893-133X, 9 p.Article

In vitro and in vivo characterization of JNJ-31020028 N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide, a selective brain penetrant small molecule antagonist of the neuropeptide Y Y₂ receptorSHOBLOCK, James R; WELTY, Natalie; ATACK, John R et al.Psychopharmacologia. 2010, Vol 208, Num 2, pp 265-277, issn 0033-3158, 13 p.Article

Novel substituted pyrrolidines are high affinity histamine H₃ receptor antagonistsSTOCKING, Emily M; ALUISIO, Leah; LORD, Brian et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 9, pp 2755-2760, issn 0960-894X, 6 p.Article

Detection of gender differences in rat lens proteins using 2-D-DIGEGUEST, Paul C; SKYNNER, Heather A; SALIM, Kamran et al.Proteomics (Weinheim. Print). 2006, Vol 6, Num 2, pp 667-676, issn 1615-9853, 10 p.Article

Anxiogenic properties of an inverse agonist selective for α3 subunit-containing GABA_A receptorsATACK, John R; HUTSON, Peter H; DAWSON, Gerard R et al.British journal of pharmacology. 2005, Vol 144, Num 3, pp 357-366, issn 0007-1188, 10 p.Article

7-(1,1-dimethylethyl)-6-(2-ethyl-2h-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine : A functionally selective γ-aminobutyric Acid_A (GABA_A) α2/α3-subtype selective agonist that exhibits potent anxiolytic activity but is not sedating in animal modelsCARLING, Robert W; MADIN, Andrew; MCKERNAN, Ruth M et al.Journal of medicinal chemistry (Print). 2005, Vol 48, Num 23, pp 7089-7092, issn 0022-2623, 4 p.Article

Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazin es and analogues as subtype-selective inverse agonists for the GABA_Aα5 benzodiazepine binding siteSTREET, Leslie J; STERNFELD, Francine; DAWSON, Gerard R et al.Journal of medicinal chemistry (Print). 2004, Vol 47, Num 14, pp 3642-3657, issn 0022-2623, 16 p.Article

The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y₂ receptorSWANSON, Devin M; WONG, Victoria D; ATACK, John R et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 18, pp 5552-5556, issn 0960-894X, 5 p.Article

In Vivo Characterization and Dynamic Receptor Occupancy Imaging of TPA023B, an α2/α3/α5 Subtype Selective 7-Aminobutyric Acid-A Partial AgonistVAN LAERE, Koen; BORMANS, Guy; BURNS, H. Donald et al.Biological psychiatry (1969). 2008, Vol 64, Num 2, pp 153-161, issn 0006-3223, 9 p.Article

Pharmacokinetics and metabolism studies on 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy) pyrazolo[1,5-d][1,2,4]triazine, a functionally selective GABA_A α5 inverse agonist for cognitive dysfunctionJONES, Philip; ATACK, John R; SZETO, Nicola et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 4, pp 872-875, issn 0960-894X, 4 p.Article

A pyridazine series of α2/α3 subtype selective GABA_Aagonists for the treatment of anxietyLEWIS, Richard T; BLACKABY, Wesley P; REYNOLDS, David S et al.Journal of medicinal chemistry (Print). 2006, Vol 49, Num 8, pp 2600-2610, issn 0022-2623, 11 p.Article

Tricyclic pyridones as functionally selective human GABA_Aα_2/3 receptor-ion channel ligandsCRAWFORTH, James; ATACK, John R; STERNFELD, Francine et al.Bioorganic & medicinal chemistry letters (Print). 2004, Vol 14, Num 7, pp 1679-1682, issn 0960-894X, 4 p.Article

3-heteroaryl-2-pyridones: Benzodiazepine site ligands with functional selectivity for α2/α3-subtypes of human GABA_A receptor-ion channelsCOLLINS, Ian; MOYES, Christopher; DAWSON, Gerard R et al.Journal of medicinal chemistry (Print). 2002, Vol 45, Num 9, pp 1887-1900, issn 0022-2623Article

The plasma―occupancy relationship of the novel GABA_A receptor benzodiazepine site ligand, α5IA, is similar in rats and primatesATACK, John R; ENG, Wai-Si; GIBSON, Ray E et al.British journal of pharmacology. 2009, Vol 157, Num 5, pp 796-803, issn 0007-1188, 8 p.Article

Discovery of imidazo[1,2-b][1,2,4]triazines as GABA_A α2/3 subtype selective agonists for the treatment of anxietyRUSSELL, Michael G. N; CARLING, Robert W; SMITH, Alison J et al.Journal of medicinal chemistry (Print). 2006, Vol 49, Num 4, pp 1235-1238, issn 0022-2623, 4 p.Article

A new pyridazine series of GABA_A α5 ligandsVAN NIEL, Monique B; WILSON, Kevin; MAUBACH, Karen et al.Journal of medicinal chemistry (Print). 2005, Vol 48, Num 19, pp 6004-6011, issn 0022-2623, 8 p.Article

Pyrazolopyridinones as functionally selective GABA_A ligandsBLACKABY, Wesley P; ATACK, John R; BROMIDGE, Frances et al.Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 22, pp 4998-5002, issn 0960-894X, 5 p.Article