Inhibition of HIV entry by carbohydrate-binding proteinsBALZARINI, J.Antiviral research. 2006, Vol 71, Num 2-3, pp 237-247, issn 0166-3542, 11 p.Article

Suppression of resistance to drugs targeted to human immunodeficiency virus reverse transcriptase by combination therapyBALZARINI, J.Biochemical pharmacology. 1999, Vol 58, Num 1, pp 1-27, issn 0006-2952Article

Assay method for monitoring the inhibitory effects of antimetabolites on the activity of inosinate dehydrogenase in intact human CEM lymphocytesBALZARINI, J; DE CLERCQ, E.Biochemical journal (London. 1984). 1992, Vol 287, pp 785-790, issn 0264-6021, 3Article

Acyclic and carbocyclic nucleoside analogues as inhibitors of HIV replicationBALZARINI, J; DE CLERCQ, E.Pharmacochemistry library. 1990, Vol 14, pp 175-194, issn 0165-7208, 20 p.Article

The thiocarboxanilides UC-10 and UC-781 have an additive inhibitory effect against human immunodeficiency virus type 1 reverse transcriptase and replication in cell culture when combined with other antiretroviral drugsBALZARINI, J; DE CLERCQ, E.Antiviral chemistry & chemotherapy. 1997, Vol 8, Num 3, pp 197-204, issn 0956-3202Article

9-β-D-arabinofuranosyladenine 5'-monophosphate (araAMP) is converted directly to its antivirally active 5'-triphosphate form by 5-phosphoribosyl-1-pyrophosphate (PRPP) synthetaseBALZARINI, J; DE CLERCQ, E.Biochemical and biophysical research communications (Print). 1990, Vol 173, Num 3, pp 781-787, issn 0006-291X, 7 p.Article

Strategies for the measurement of the inhibitory effects of thymidine analogs on the activity of thymidylate synthase in intact murine leukemia L1210 cellsBALZARINI, J; DE CLERCQ, E.Biochimica et biophysica acta. 1984, Vol 785, Num 1-2, pp 36-45, issn 0006-3002Article

Rapid alternation of drug therapy is highly efficient in suppressing the emergence of mutant drug-resistant HIV strains in cell cultureBALZARINI, J; DE CLERCQ, E.AIDS research and human retroviruses. 2001, Vol 17, Num 17, pp 1625-1634, issn 0889-2229Article

5-Phosphoribosyl 1-pyrophosphate synthetase converts the acyclic nucleoside phosphonates 6-(2-hydroxy-2-phosphonylmethoxypropyl)adenine ,and 9-(2-phosphonylmethoxyethyl)adenine directly to their antivirally active diphosphate derivativesBALZARINI, J; DE CLERQ, E.The Journal of biological chemistry (Print). 1991, Vol 266, Num 14, pp 8686-8689, issn 0021-9258, 4 p.Article

SIV/HIV-1 hybrid virus expressing the reverse transcriptase gene of HIV-1 remains sensitive to HIV-1-specific reverse transcriptase inhibitors after passage in rhesus macaquesBALZARINI, J; DE CLERCQ, E; ÜBERLA, K et al.Journal of acquired immune deficiency syndromes and human retrovirology. 1997, Vol 15, Num 1, pp 1-4, issn 1077-9450Article

Differential mechanism of cytostatic effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine, 9-(1,3-dihydroxy-2-propoxymethyl)guanine, and other antiherpetic drugs on tumor cells transfected by the thymidine kinase gene of herpes simplex virus type 1 or type 2BALZARINI, J; BOHMAN, C; DE CLERCQ, E et al.The Journal of biological chemistry (Print). 1993, Vol 268, Num 9, pp 6332-6337, issn 0021-9258Article

Pharmacokinetics in mice of the anti-retrovirus agent 9-(2-phosphonylmethoxyethyl)adenineNAESSENS, L; BALZARINI, J; DE CLERCQ, E et al.Drug metabolism and disposition. 1992, Vol 20, Num 5, pp 747-752, issn 0090-9556Article

Mechanism of antiviral and cytotoxic action of (±)-6'β-fluoroaristeromycin, a potent inhibitor of S-adenosylhomocysteine hydrolaseCOOLS, M; BALZARINI, J; DE CLERCQ, E et al.Molecular pharmacology. 1991, Vol 39, Num 6, pp 718-724, issn 0026-895X, 7 p.Article

Estimation of the lipophilicity of anti-HIV nucleoside analogues by determination of the partition coefficient and retention time on a lichrospher 60 RP-8 HPLC columnBALZARINI, J; COOLS, M; DE CLERCQ, E et al.Biochemical and biophysical research communications (Print). 1989, Vol 158, Num 2, pp 413-422, issn 0006-291XArticle

Homocysteine potentiates the antiviral and cytostatic activity of those nucleoside analogues that are targeted at S-adenosylhomocysteine hydrolaseDE CLERCQ, E; COOLS, M; BALZARINI, J et al.Biochemical pharmacology. 1989, Vol 38, Num 11, pp 1771-1778, issn 0006-2952Article

SYNTHESIS AND BIOLOGICAL PROPERTIES OF 2'-DEOXY-5-VINYLURIDINE AND 2'-DEOXY-5-VINYLKYTIDINERAHIM SG; DUGGAN MJH; WALKER RT et al.1982; NUCLEIC ACIDS RES.; ISSN 0305-1048; GBR; DA. 1982; VOL. 10; NO 17; PP. 5285-5295; BIBL. 21 REF.Article

Role of antimetabolites of purine and pyrimidine nucleotide metabolism in tumor cell differentiationHATSE, S; DE CLERCQ, E; BALZARINI, J et al.Biochemical pharmacology. 1999, Vol 58, Num 4, pp 539-555, issn 0006-2952Article

Differential activities of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives against different human immunodefiency virus type 1 mutant strainsBALZARINI, J; MASANORI BABA; DE CLERCQ, E et al.Antimicrobial agents and chemotherapy. 1995, Vol 39, Num 4, pp 998-1002, issn 0066-4804Article

Human immunodeficiency virus type 1 drug-resistance patterns with different 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivativesBALZARINI, J; KARLSSON, A; DE CLERCQ, E et al.Molecular pharmacology. 1993, Vol 44, Num 4, pp 694-701, issn 0026-895XArticle

Acyclic adenine nucleoside phosphonates in plasma determined by high-performance liquid chromatography with fluorescence detectionNAESENS, L; BALZARINI, J; DE CLERCQ, E et al.Clinical chemistry (Baltimore, Md.). 1992, Vol 38, Num 4, pp 480-485, issn 0009-9147Article

Potent differentiation-inducing properties of the antiretroviral agent 9-(2-phosphonylmethoxyethyl) adenine (PMEA) in the rat choriocarcinoma (RCHO) tumor cell modelHATSE, S; NAESENS, L; DE CLERCQ, E et al.Biochemical pharmacology. 1998, Vol 56, Num 7, pp 851-859, issn 0006-2952Article

Aurintricarboxylic acid and Evans Blue represent two different classes of anionic compounds which selectively inhibit the cytopathogenicity of human T-cell lymphotropic virus type III/lymphadenopathy-associated virusBALZARINI, J; MITSUYA, H; DE CLERCQ, E et al.Biochemical and biophysical research communications (Print). 1986, Vol 136, Num 1, pp 64-71, issn 0006-291XArticle

9-(2-Phosphonylmethoxyethyl)adenine induces tumor cell differentiation or cell death by blocking cell cycle progression through the S phaseHATSE, S; SCHOLS, D; DE CLERCQ, E et al.Cell growth and differentiation. 1999, Vol 10, Num 6, pp 435-446, issn 1044-9523Article

A novel mutation (F227L) arises in the reverse transcriptase of human immunodeficiency virus type 1 on dose-escalating treatment of HIV type 1-infected cell cultures with the nonnucleoside reverse transcriptase inhibitor thiocarboxanilide UC-781BALZARINI, J; PELEMANS, H; ESNOUF, R et al.AIDS research and human retroviruses. 1998, Vol 14, Num 3, pp 255-260, issn 0889-2229Article

Cyclic saligenyl phosphotriesters of 2',3'-dideoxy-2',3'-didehydrothymidine (d4T) : A new pro-nucleotide approachMEIER, C; LOREY, M; DE CLERCQ, E et al.Bioorganic & medicinal chemistry letters (Print). 1997, Vol 7, Num 2, pp 99-104, issn 0960-894XArticle