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Synthesis and inhibition of Src kinase activity by 7-ethenyl and 7-ethynyl-4-anilino-3-quinolinecarbonitrilesBARRIOS SOSA, Ana Carolina; BOSCHELLI, Diane H; FEI YE et al.Bioorganic & medicinal chemistry letters (Print). 2004, Vol 14, Num 9, pp 2155-2158, issn 0960-894X, 4 p.Article

Inhibition of Src kinase activity by 4-anilino-5,10-dihydropyrimido[4,5-b]quinolinesBOSCHELLI, Diane H; POWELL, Dennis; GOLAS, Jennifer M et al.Bioorganic & medicinal chemistry letters (Print). 2003, Vol 13, Num 18, pp 2977-2980, issn 0960-894X, 4 p.Article

A Src/Abl kinase inhibitor, SKI-606, blocks breast cancer invasion, growth, and metastasis in vitro and in vivoJALLAL, Houda; VALENTINE, Maria-Luisa; GAOPING CHEN et al.Cancer research (Baltimore). 2007, Vol 67, Num 4, pp 1580-1588, issn 0008-5472, 9 p.Article

Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activityZAPF, Christoph W; BLOOM, Jonathan D; HAO LIU et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 8, pp 2278-2282, issn 0960-894X, 5 p.Article

8-Anilinoimidazo[4,5-g]quinoline-7-carbonitriles as Src kinase inhibitorsBERGER, Dan; DUTIA, Minu; POWELL, Dennis et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 19, pp 2761-2765, issn 0960-894X, 5 p.Article

Substituted 4-anilino-7-phenyl-3-quinolinecarbonitriles as Src kinase inhibitorsBERGER, Dan; DUTIA, Minu; POWELL, Dennis et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 20, pp 2989-2992, issn 0960-894X, 4 p.Article

Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activityZAPF, Christoph W; BLOOM, Jonathan D; BOSCHELLI, Frank et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 11, pp 3411-3416, issn 0960-894X, 6 p.Article

Optimization of 7-alkene-3-quinolinecarbonitriles as Src kinase inhibitorsBOSCHELLI, Diane H; WANG, Daniel; YAN WANG et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 9, pp 2924-2927, issn 0960-894X, 4 p.Article

Inhibition of Src kinase activity by 4-anilino-7-thienyl-3-quinolinecarbonitrilesBOSCHELLI, Diane H; WANG, Daniel Y; FEI YE et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 15, pp 2011-2014, issn 0960-894XArticle

Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor which significantly decreases tumor volume in a mouse xenograft modelZAPF, Christoph W; BLOOM, Jonathan D; BOSCHELLI, Frank et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 15, pp 4602-4607, issn 0960-894X, 6 p.Article

Valproic acid enhances bosutinib cytotoxicity in colon cancer cellsMOLOGNI, Luca; CLERIS, Loredana; MAGISTRONI, Vera et al.International journal of cancer (Print). 2009, Vol 124, Num 8, pp 1990-1996, issn 0020-7136, 7 p.Article

Synthesis and Src kinase inhibitory activity of a series of 4-phenylamino-3-quinolinecarbonitrilesBOSCHELLI, Diane H; WANG, Yanong D; BOSCHELLI, Frank et al.Journal of medicinal chemistry (Print). 2001, Vol 44, Num 5, pp 822-833, issn 0022-2623Article

Inhibitors of Src tyrosine kinase : The preparation and structure-activity relationship of 4-anilino-3-cyanoquinolines and 4-anilinoquinazolinesWANG, Yanong D; MILLER, Karen; BOSCHELLI, Diane H et al.Bioorganic & medicinal chemistry letters (Print). 2000, Vol 10, Num 21, pp 2477-2480, issn 0960-894XArticle

Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft modelZAPF, Christoph W; BLOOM, Jonathan D; MCBEAN, Jamie L et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 12, pp 3627-3631, issn 0960-894X, 5 p.Article

Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatmentMILLER, Lori M; MAYER, Scott C; HESS KENNY, Cynthia et al.Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 1, pp 62-66, issn 0960-894X, 5 p.Article

Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Heat Shock Protein 90GOPALSAMY, Ariamala; SHI, Mengxiao; CHOPRA, Rajiv et al.Journal of medicinal chemistry (Print). 2008, Vol 51, Num 3, pp 373-375, issn 0022-2623, 3 p.Article

Facile preparation of new 4-phenylamino-3-quinolinecarbonitrile Src kinase inhibitors via 7-fluoro intermediates : Identification of potent 7-amino analogsBOSCHELLI, Diane H; BIQI WU; FEI YE et al.Bioorganic & medicinal chemistry. 2008, Vol 16, Num 1, pp 405-412, issn 0968-0896, 8 p.Article

In vitro and in vivo activity of SKI-606, a novel Src-Abi inhibitor, against imatinib-resistant Bcr-Abl⁺ neoplastic cellsPUTTINI, Miriam; LUCE COLUCCIA, Addolorata Maria; ANDREONI, Federica et al.Cancer research (Baltimore). 2006, Vol 66, Num 23, pp 11314-11322, issn 0008-5472, 9 p.Article

SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft modelsGALAS, Jennifer M; LUCAS, Judy; FANGBIAO LI et al.Cancer research (Baltimore). 2005, Vol 65, Num 12, pp 5358-5364, issn 0008-5472, 7 p.Article

SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude miceGOLAS, Jennifer M; ARNDT, Kim; ETIENNE, Carlo et al.Cancer research (Baltimore). 2003, Vol 63, Num 2, pp 375-381, issn 0008-5472, 7 p.Article

Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activityBOSCHELLI, Diane H; FEI YE; TISCHLER, Mark et al.Journal of medicinal chemistry (Print). 2001, Vol 44, Num 23, pp 3965-3977, issn 0022-2623Article