A PERSPECTIVE ON THE ROLE OF CHEMICALLY REACTIVE METABOLITES OF FOREIGN COMPOUNDS IN TOXICITY. II. ALTERATIONS IN THE KINETICS OF COVALENT BINDING = REVUE SUR LE ROLE DES METABOLITES CHIMIQUEMENT REACTIFS DES COMPOSES ETRANGERS DANS LA TOXICITE. II. MODIFICATIONS DANS LA CINETIQUE DE LA LIAISON COVALENTEGILLETTE JR.1974; BIOCHEM. PHARMACOL.; G.B.; DA. 1974; VOL. 23; NO 21; PP. 2927-2938; BIBL. 29REF.Article

KINETICS OF DECOMPOSITION OF CHEMICALLY UNSTABLE METABOLITES IN THE PRESENCE OF NUCLEOPHILES: DERIVATION OF EQUATIONS USED IN GRAPHICAL ANALYSESGILLETTE JR.1980; PHARMACOLOGY; CHE; DA. 1980; VOL. 20; NO 2; PP. 64-86; BIBL. 4 REF.Article

SEQUENTIAL FIRST-PASS ELIMINATION OF A METABOLITE DERIVED FROM A PRECURSORPANG KS; GILLETTE JR.1979; J. PHARMACOKINET. BIOPHARMACEUT.; GBR; DA. 1979; VOL. 7; NO 3; PP. 275-290; BIBL. 13 REF.Article

METABOLITE PHARMACOKINETICS: METHODS FOR SIMULTANEOUS ESTIMATES OF ELIMINATION RATE CONSTANTS OF A DRUG AND ITS METABOLITE: A COMMENTARYPANG KS; GILLETTE JR.1980; DRUG METABOL. DISPOSIT.; USA; DA. 1980; VOL. 8; NO 1; PP. 39-44; BIBL. 3 REF.Article

KINETIES OF METABOLITE FORMATION AND ELIMINATION IN THE PERFUSED RAT LIVER PREPARATION: DIFFERENCES BETWEEN THE ELIMINATION OF PREFORMED ACETAMINOPHEN AND ACETAMINOPHEN FORMED FROM PHENACETINPANG KS; GILLETTE JR.1978; J. PHARMACOL. EXPER. THERAPEUT.; USA; DA. 1978; VOL. 207; NO 1; PP. 178-194; BIBL. 1 P.Article

A THEORETICAL EXAMINATION OF THE EFFECTS OF GUT WALL METABOLISM, HEPATIC ELIMINATION, AND ENTEROHEPATIC RECYCLING ON ESTIMATES OF BIOAVAILABILITY AND OF HEPATIC BLOOD FLOWPANG KS; GILLETTE JR.1978; J. PHARMACOKINET. BIOPHARMACEUT.; GBR; DA. 1978; VOL. 6; NO 5; PP. 355-367; BIBL. 5 REF.Article

COMPLICATIONS IN THE ESTIMATION OF HEPATIC BLOOD FLOW IN VIVO BY PHARMACOKINETIC PARAMETERS. THE AREA UNDER THE CURVE AFTER THE CONCOMITANT INTRAVENOUS AND INTRAPERITONEAL (OR INTRAPORTAL) ADMINISTRATION OF ACETAMINOPHEN IN THE RAT.SANDY PANG K; GILLETTE JR.1978; DRUG METABOL. DISPOSIT.; USA; DA. 1978; VOL. 6; NO 5; PP. 567-576; BIBL. 41 REF.Article

METABOLISM, TISSUE DISTRIBUTION AND COVALENT BINDING OF TRIPELENNAMINE AND ITS N-NITROSO DERIVATIVE IN THE RAT. = METABOLISME, REPARTITION TISSULAIRE ET FIXATION COVALENTE DE LA TRIPELENNANINE ET DE SON DERIVE N-NITROSE CHEZ LE RATSUBBA RAO G; GOPAL KRISHNA; GILLETTE JR et al.1975; J. PHARMACOL. EXPER. THERAPEUT.; U.S.A.; DA. 1975; VOL. 195; NO 3; PP. 433-440; BIBL. 1 P.Article

BROMOBENZENE AND P-BROMOPHENOL TOXICITY AND COVALENT BINDING IN VIVOMONKS TJ; HINSON JA; GILLETTE JR et al.1982; LIFE SCI. (1973); ISSN 0024-3205; GBR; DA. 1982; VOL. 30; NO 10; PP. 841-848; BIBL. 28 REF.Article

BIOACTIVATION OF CARBON TETRACHLORIDE, CHLOROFORM AND BROMOTRICHLOROMETHANE: ROLE OF CYTOCHROME P-450.SIPES IG; GOPAL KRISHNA; GILLETTE JR et al.1977; LIFE SCI.; G.B.; DA. 1977; VOL. 20; NO 9; PP. 1541-1548; BIBL. 32 REF.Article

A NEW PRINCIPLE FOR ESTIMATING HEPATIC BLOOD FLOW RATESGILLETTE JR; SAUL WF; MALING HM et al.1981; PHARMACOLOGY; ISSN 0031-7012; CHE; DA. 1981; VOL. 23; NO 5; PP. 237-246; BIBL. 15 REF.Article

SPIRONOLACTONE AND CYTOCHROME P-450: IMPAIRMENT OF STEROID 21-HYDROXYLATION IN THE ADRENAL CORTEXMENARD RH; BARTTER FC; GILLETTE JR et al.1976; ARCH. BIOCHEM. BIOPHYS.; U.S.A.; DA. 1976; VOL. 173; NO 2; PP. 395-402; BIBL. 9 REF.Article

EFFECTS OF ANTI-NADPH-CYTOCHROME C REDUCTASE AND ANTI-CYTOCHROME B₅ ANTIBODIES ON THE HEPATIC AND PULMONARY MICROSOMAL METABOLISM AND COVALENT BINDING OF THE PULMONARY TOXIN 4-IPOMEANOLSASAME HA; GILLETTE JR; BOYD MR et al.1978; BIOCHEM. BIOPHYS. RES. COMMUNIC.; USA; DA. 1978; VOL. 84; NO 2; PP. 389-395; BIBL. 9 REF.Article

ENZYMATIC FORMATION OF CHEMICALLY REACTIVE METABOLITES OF N-NITROSO-DESMETHYL TRIPELNNAMINE BY A MECHANISM OTHER THAN N-DEALKYLATION = LA FORMATION ENZYMATIQUE DE METABOLITES CHIMIQUEMENT REACTIFS DE LA N-NITROSO-DESMETHYL TRIPELENNAMINE PAR UN MECANISME AUTRE QUE LA N-DEALKYLATIONSUBBA RAO G; KRISHNA G; GILLETTE JR et al.1975; BIOCHEM PHARMACOL.; G.B.; DA. 1975; VOL. 24; NO 18; PP. 1707-1711; BIBL. 25 REF.Article

EFFECT OF CHRONIC TREATMENT WITH PHENOBARBITAL OR 3-METHYLCHOLANTHRENE ON THE MALE REPRODUCTIVE SYSTEM IN RATS = EFFET DU TRAITEMENT CHRONIQUE PAR LE PHENOBARBITAL OU LE METHYL-3 CHOLANTHRENE SUR LE SYSTEME REPRODUCTEUR MALE CHEZ LES RATSSTRIPP B; MENARD RH; GILLETTE JR et al.1974; LIFE SCI.; G.B.; DA. 1974; VOL. 14; NO 11; PP. 2121-2130; BIBL. 1P.Article

ENZYMATIC OXIDATION OF DIPHENYLMETHYLPHOSPHINE AND 3-DIMETHYLAMINOPROPYLDIPHENYLPHOSPHINE BY RAT LIVER MICROSOMES = L'OXYDATION ENZYMATIQUE DE LA DIPHENYLMETHYLPHOSPHINE ET DE LA DIMETHYLAMINOPROPYL DIPHENYLPHOSPHINE PAR LES MICROSOMES DU FOIE DU RATWILEY RA; STERNSON LA; SASAME HA et al.1972; BIOCHEM. PHARMACOL.; G.B.; DA. 1972; VOL. 21; NO 24; PP. 3235-3247; BIBL. 14REF.Serial Issue

STUDIES OF THE DESTRUCTION OF ADRENAL AND TESTICULAR CYTOCHROME P-450 BY SPIRONOLACTONE. REQUIREMENT FOR THE 7ALPHA -THIO GROUP AND EVIDENCE FOR THE LESS OF THE HEME AND APOPROTEINS OF CYTOCHROME P-450MENARD RH; GUENTHNER TM; KON H et al.1979; J. BIOL. CHEM.; USA; DA. 1979; VOL. 254; NO 5; PP. 1726-1733; BIBL. 28 REF.Article

STUDIES ON THE MECHANISM OF THE LUNG TOXICITY OF PARAQUAT: COMPARISON OF TISSUE DISTRIBUTION AND SOME BIOCHEMICAL PARAMETERS IN RATS AND RABBITS = RECHERCHES SUR LE MECANISME DE LA TOXICITE PULMONAIRE DU PARAQUAT: COMPARAISON DE LA REPARTITION TISSULAIRE ET DE QUELQUES PARAMETRES BIOCHIMIQUES CHEZ LES RATS ET LES LAPINSILETT KF; STRIPP B; MENARD RH et al.1974; TOXICOL. APPL. PHARMACOL.; U.S.A.; DA. 1974; VOL. 28; NO 2; PP. 216-226; BIBL. 1P.1/2Article

ENHANCED HEPATIC MICROSOMAL ACTIVITY BY PRETREATMENT OF RAT WITH ACETONE OR ISOPROPANOL = AUGMENTATION DE L'ACTIVITE DES MICROSOMES HEPATIQUES PAR LE TRAITEMENT PREALABLE DE RAT PAR L'ACETONE OU L'ISOPROPANOLSIPES IG; STRIPP B; GOPAL KRISHNA et al.1973; PROC. SOC. EXPER. BIOL. MED.; U.S.A.; DA. 1973; VOL. 142; NO 1; PP. 237-240; BIBL. 22 REF.Serial Issue

3-HYDROXYACETAMINOPHEN: A MICROSOMAL METABOLITE OF ACETAMINOPHEN. EVIDENCE AGAINST AN EPOXIDE AS THE REACTIVE METABOLITE OF ACETAMINOPHENHINSON JA; POHL LR; MONKS TJ et al.1980; DRUG METAB. DISPOS.; ISSN 0090-9556; USA; DA. 1980; VOL. 8; NO 5; PP. 289-294; BIBL. 29 REF.Article

SPIRONOLACTONE AND CYTOCHROME P-450: IMPAIRMENT OF STEROID HYDROXYLATION IN THE ADRENAL CORTEX = SPIROLACTONE ET CYTOCHROME P-450: PERTURBATION DE L'HYDROXYLATION DES CORTICOSTEROIDES DANS LA CORTICO SURRENALEMENARD RH; MARTIN HF; STRIPP B et al.1974; LIFE SCI.; G.B.; DA. 1974; VOL. 15; NO 9; PP. 1639-1648; BIBL. 6REF.Article

PRODUCTION OF DIMER OF 2-ACETYLAMINOFLUORENE DURING THE SULFATION OF N-HYDROXY-2-ACETYLAMINOFLUORENE IN VITROANDREWS LS; POHL LR; HINSON JA et al.1979; DRUG METABOL. DISPOSIT.; USA; DA. 1979; VOL. 7; NO 5; PP. 296-300; BIBL. 23 REF.Article

BROMOBENZENE-INDUCED LIVER NECROSIS. PROTECTIVE ROLE OF GLUTATHIONE AND EVIDENCE FOR 3,4-BROMOBENZENE OXIDE AS THE HEPATOTOXIC METABOLITE = LA NECROSE HEPATIQUE INDUITE PAR LE BROMOBENZENE. LE ROLE PROTECTEUR DU GLUTATHION ET LA MISE EN EVIDENCE DE L'EPOXYDE 3,4 DU BROMOBENZENE EN TANT QUE METABOLITE HEPATOTOXIQUEJOLLOW DJ; MITCHELL JR; ZAMPAGLIONE N et al.1974; PHARMACOLOGY; SWITZ.; DA. 1974; VOL. 11; NO 3; PP. 151-169; BIBL. 2P.Article

INVESTIGATION OF THE EFFECTS OF METHYLTESTOSTERONE, CORTISONE AND SPIRONOLACTONE ON THE HEPATIC MICROSOMAL MIXED FUNCTION OXIDASE SYSTEM IN MALE AND FEMALE RATS = RECHERCHES SUR LES EFFETS DE LA METHYLTESTOSTERONE, DE LA CORTISONE ET DE LA SPIRONOLACTONE SUR LE SYSTEME DE L'OXYDASE A FONCTION MIXTE DES MICROSOMES HEPATIQUES CHEZ LES RATS MALES ET FEMELLESHAMRICK ME; ZAMPAGLIONE NG; STRIPP B et al.1973; BIOCHEM. PHARMACOL.; G.B.; DA. 1973; VOL. 22; NO 3; PP. 293-310; BIBL. 30 REF.Serial Issue

REDUCED BODY CLEARANCE AS THE MAJOR MECHANISM OF THE POTENTIATION BY BETA ₂-ADRENERGIC AGONISTS OF PARAQUAT LETHALITY IN RATS.MALING HM; SAUL W; WILLIAMS MA et al.1978; TOXICOL. APPL. PHARMACOL.; U.S.A.; DA. 1978; VOL. 43; NO 1; PP. 57-72; BIBL. 1 P.Article