Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulatorsMONAGHAN, Daniel T; IRVINE, Mark W; MATHIAS COSTA, Blaise et al.Neurochemistry international. 2012, Vol 61, Num 4, pp 581-592, issn 0197-0186, 12 p.Article

Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-methyl-D-aspartate receptorsIRVINE, Mark W; COSTA, Blaise M; VOLIANSKIS, Arturas et al.Neurochemistry international. 2012, Vol 61, Num 4, pp 593-600, issn 0197-0186, 8 p.Article

Design and synthesis of substituted N-(1,3-diphenyl-1H-pyrazol-5-yl)-benzamides as positive allosteric modulators of the metabotropic glutamate receptor subtype 5ZOU, Mu-Fa; JIANJINGCAO; RODRIGUEZ, Alice L et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 9, pp 2650-2654, issn 0960-894X, 5 p.Article

New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): Identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolonesTRABANCO, Andrés A; DUVEY, Guillaume; LAVREYSEN, Hilde et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 3, pp 971-976, issn 0960-894X, 6 p.Article

Discovery of molecular switches within the ADX-47273 mGlu₅ PAM scaffold that modulate modes of pharmacology to afford potent mGlu₅ NAMs, PAMs and partial antagonistsLAMB, Jeffrey P; ENGERS, Darren W; NISWENDERA, Colleen M et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 9, pp 2711-2714, issn 0960-894X, 4 p.Article

Potent mGluR5 antagonists: Pyridyl and thiazolyl-ethynyl-3,5-disubstituted-phenyl seriesALAGILLE, David; DACOSTA, Herve; CHEN, Yelin et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 11, pp 3243-3247, issn 0960-894X, 5 p.Article

Hit-to-lead optimization of disubstituted oxadiazoles and tetrazoles as mGluRS NAMsWAGNER, Gábor; WEBER, Csaba; NAGY, József et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 12, pp 3737-3741, issn 0960-894X, 5 p.Article

A novel series of positive modulators of the AMPA receptor: Structure-based lead optimizationJAMIESON, Craig; CAMPBELL, Robert A; MARTIN, Frederic et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 20, pp 6072-6075, issn 0960-894X, 4 p.Article

N-Substituted pyrrolidines and tetrahydrofurans as novel AMPAR positive modulatorsTHEWLIS, Kevin M; ALDEGHERI, Laura; HARRIES, Mark H et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 23, pp 7116-7119, issn 0960-894X, 4 p.Article

Discovery of a potent and brain penetrant mGluRS positive allosteric modulatorRITZEN, Andreas; SINDET, Rikke; HENTZER, Morten et al.Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 12, pp 3275-3278, issn 0960-894X, 4 p.Article

Structure―Activity Relationships Comparing N-(6-Methylpyridin-yl)-Substituted Aryl Amides to 2-Methyl-6-(substituted-arylethynyl)pyridines or 2-Methyl-4-(substituted-arylethynyl)thiazoles as Novel Metabotropic Glutamate Receptor Subtype 5 AntagonistsKULKARNI, Santosh S; ZOU, Mu-Fa; JIANJING CAO et al.Journal of medicinal chemistry (Print). 2009, Vol 52, Num 11, pp 3563-3575, issn 0022-2623, 13 p.Article

Synthesis and evaluation of novel tricyclic benzo[4.5]cyclohepta[1.2]pyridine derivatives as NMDA/NR2B antagonistsMCINTYRE, Charles J; MCCAULEY, John A; KOBLAN, Ken S et al.Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 17, pp 5132-5135, issn 0960-894X, 4 p.Article

The discovery of a structurally novel class of inhibitors of the type 1 glycine transporterLOWE, John A; XINJUN HOU; TUNUCCI, Don et al.Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 11, pp 2974-2976, issn 0960-894X, 3 p.Article

Hydroxamic Acids As a Novel Family of Serine Racemase Inhibitors: Mechanistic Analysis Reveals Different Modes of Interaction with the Pyridoxal-5'-phosphate CofactorHOFFMAN, Hillary E; JIRASKOVA, Jana; CIGLER, Petr et al.Journal of medicinal chemistry (Print). 2009, Vol 52, Num 19, pp 6032-6041, issn 0022-2623, 10 p.Article

3D-QSAR studies of triazafluorenone inhibitors of metabotropic glutamate receptor subtype 1NATARAJA SEKHAR, Y; RAVIKUMAR, Muttineni; RAVI SHASHI NAYANA, M et al.European journal of medicinal chemistry. 2008, Vol 43, Num 5, pp 1025-1034, issn 0223-5234, 10 p.Article

Structures of the Ligand-Binding Core of iGluR2 in Complex with the Agonists (R)-and (S)-2-Amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic Acid Explain Their Unusual EquipotencyBEICH-FRANDSEN, Mads; PICKETING, Darryl S; MIRZA, Osman et al.Journal of medicinal chemistry (Print). 2008, Vol 51, Num 5, pp 1459-1463, issn 0022-2623, 5 p.Article

Synthesis and Biological Evaluation of D-Amino Acid Oxidase InhibitorsFERRARIS, Dana; DUVALL, Bridget; KO, Yao-Sen et al.Journal of medicinal chemistry (Print). 2008, Vol 51, Num 12, pp 3357-3359, issn 0022-2623, 3 p.Article

Synthesis and SAR of a mGluR5 allosteric partial antagonist lead : Unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffoldSHARMA, Sameer; RODRIGUEZ, Alice L; CONN, P. Jeffrey et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 14, pp 4098-4101, issn 0960-894X, 4 p.Article

Synthesis and characterization of 8-ethynyl-1,3-dihydrobenzo[b][1,4]diazepin-2-one derivatives: Part 2. New potent non-competitive metabotropic glutamate receptor 2/3 antagonistsWELTERING, Thomas J; ADAM, Geo; WICHMANN, Jürgen et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 3, pp 1091-1095, issn 0960-894X, 5 p.Article

3-(Imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-ylmethyl ethers : A novel series of mGluR2 positive allosteric modulatorsLEI ZHANG; ROGERS, Bruce N; DORAN, Angela C et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 20, pp 5493-5496, issn 0960-894X, 4 p.Article

Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonistsKULKARNI, Santosh S; HAUCK NEWMAN, Amy.Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 11, pp 2987-2991, issn 0960-894X, 5 p.Article

Glutamate-modulating drugs : & the treatment of mental disordersHOWLAND, Robert H.Journal of psychosocial nursing and mental health services. 2007, Vol 45, Num 1, issn 0279-3695, 3, 11-14 [5 p.]Article

Novel 5-substituted 1-pyrazolol analogues of ibotenic acid : Synthesis and pharmacology at glutamate receptorsJØRGENSEN, Charlotte G; BRÄUNER-OSBORNE, Hans; NIELSEN, Birgitte et al.Bioorganic & medicinal chemistry. 2007, Vol 15, Num 10, pp 3524-3538, issn 0968-0896, 15 p.Article

Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2' -phosphono -3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans_c1'-2'-2-(2 '-phosphonocyclopropyl)glycinesMARINOZZI, Maura; SERPI, Michaela; GIORGI, Gianluca et al.Bioorganic & medicinal chemistry. 2007, Vol 15, Num 9, pp 3161-3170, issn 0968-0896, 10 p.Article

Structure-activity relationship studies on N³-substituted willardiine derivatives acting as AMPA or kainate receptor antagonistsDOLMAN, Nigel P; MORE, Julia C. A; ALT, Andrew et al.Journal of medicinal chemistry (Print). 2006, Vol 49, Num 8, pp 2579-2592, issn 0022-2623, 14 p.Article