4-Oxo-β-lactams (Azetidine-2,4-diones) Are Potent and Selective Inhibitors of Human Leukocyte ElastaseMULCHANDE, Jalmira; OLIVEIRA, Rudi; CARRASCO, Marta et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 1, pp 241-253, issn 0022-2623, 13 p.Article

5-Modified-2'-dU and 2'-dC as Mutagenic Anti HIV-1 Proliferation Agents: Synthesis and ActivityEL SAFADI, Yazan; PAILLART, Jean-Christophe; LAUMOND, Géraldine et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 4, pp 1534-1545, issn 0022-2623, 12 p.Article

Antisense Oligonucleotides Containing Conformationally Constrained 2',4'-(N Methoxy)aminomethylene and 2',4'-Aminooxymethylene and 2'-O,4'-C-Aminomethylene Bridged Nucleoside Analogues Show Improved Potency in Animal ModelsPRAKASH, Thazha P; SIWKOWSKI, Andrew; ALLERSON, Charles R et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 4, pp 1636-1650, issn 0022-2623, 15 p.Article

Characterization of Sirtuin Inhibitors in Nematodes Expressing a Muscular Dystrophy Protein Reveals Muscle Cell and Behavioral Protection by Specific Sirtinol AnaloguesPASCO, Matthieu Y; ROTILI, Dante; ALTUCCI, Lucia et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 3, pp 1407-1411, issn 0022-2623, 5 p.Article

Chloro-Substituted 3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-Dioxides as ATP-Sensitive Potassium Channel Activators: Impact of the Position of the Chlorine Atom on the Aromatic Ring on Activity and Tissue SelectivityPIROTTE, Bernard; DE TULLIO, Pascal; NGUYEN, Quynh-Anh et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 1, pp 147-154, issn 0022-2623, 8 p.Article

Design and Synthesis of Novel Quinone Inhibitors Targeted to the Redox Function of Apurinic/Apyrimidinic Endonuclease 1/Redox Enhancing Factor-1 (Ape1/Ref-1)NYLAND, Rodney L; MEIHUA LUO; KELLEY, Mark R et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 3, pp 1200-1210, issn 0022-2623, 11 p.Article

Design, Synthesis, and Docking Studies of Novel Benzimidazoles for the Treatment of Metabolic SyndromeMIZUNO, Cassia S; CHITTIBOYINA, Amar G; SHAH, Falgun H et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 3, pp 1076-1085, issn 0022-2623, 10 p.Article

Discovery of Novel Fibroblast Growth Factor Receptor 1 Kinase Inhibitors by Structure-Based Virtual ScreeningRAVINDRANATHAN, Krishna P; MANDIYAN, Valsan; EKKATI, Anil R et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 4, pp 1662-1672, issn 0022-2623, 11 p.Article

In Vivo Positron Emission Tomography (PET) Imaging of Mesenchymal―Epithelial Transition (MET) ReceptorCHUNYING WU; ZHE TANG; WEIWEN FAN et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 1, pp 139-146, issn 0022-2623, 8 p.Article

One Step Radiosynthesis of 6-[¹⁸F]Fluoronicotinic Acid 2,3,5,6-Tetrafluorophenyl Ester [¹⁸F]F-Py-TFI A New Prosthetic Group for Efficient Labeling of Biomolecules with Fluorine-18OLBERG, Dag E; ARUKWE, Joseph M; GRACE, David et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 4, pp 1732-1740, issn 0022-2623, 9 p.Article

Phosphinic Tripeptides as Dual Angiotensin-Converting Enzyme C-Domain and Endothelin-Converting Enzyme-1 InhibitorsJULLIEN, Nicolas; MAKRITIS, Anastasios; GEORGIADIS, Dimitris et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 1, pp 208-220, issn 0022-2623, 13 p.Article

Potent Inhibitors of Furin and Furin-like Proprotein Convertases Containing Decarboxylated P1 arginine MimeticsBECKER, Gero. L; SIELAFF, Frank; THAN, Manuel E et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 3, pp 1067-1075, issn 0022-2623, 9 p.Article

Structural Discovery of Small Molecule Binding Sites in Cu—Zn Human Superoxide Dismutase Familial Amyotrophic Lateral Sclerosis Mutants Provides Insights for Lead OptimizationANTONYUK, Svetlana; STRANGE, Richard W; SAMAR HASNAIN, S et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 3, pp 1402-1406, issn 0022-2623, 5 p.Article

Structure-Activity Studies of Urea, Carbamate, and Sulfonamide Derivatives of AcylfulveneMCMORRIS, Trevor C; CHIMMANI, Ramesh; ALISALA, Kashinatham et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 3, pp 1109-1116, issn 0022-2623, 8 p.Article

Structure-Function Relationships and Crystal Structures of the Vitamin D Receptor Bound 2α-Methyl-(20S,23S)- and 2α-Methyl-(20S,23R)-epoxymethano-1α,2S-dihydroxyvitamin D₃ANTONY, Pierre; SIGÜEIRO, Rita; HUET, Tiphaine et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 3, pp 1159-1171, issn 0022-2623, 13 p.Article

Synthesis and Biological Evaluation of New Podophyllic Aldehyde Derivatives with Cytotoxic and Apoptosis-Inducing ActivitiesCASTRO, Angeles; DEL CORRAL, José Mamiguel; GARCIA, Pablo A et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 3, pp 983-993, issn 0022-2623, 11 p.Article

Synthesis and Biological Evaluation of Polysulfated Oligosaccharide Glycosides as Inhibitors of Angiogenesis and Tumor GrowthJOHNSTONE, Ken D; KAROLI, Tomislav; CHIU, Francis C. K et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 4, pp 1686-1699, issn 0022-2623, 14 p.Article

Synthesis, Biological Evaluation, X-ray Structure, and Pharmacokinetics of Aminopyrimidine c-jun-N-terminal Kinase (JNK) InhibitorsKAMENECKA, Ted; RONG JIANG; CAMERON, Michael D et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 1, pp 419-431, issn 0022-2623, 13 p.Article

Two-Step Synthesis of Galactosylated Human Serum Albumin as a Targeted Optical Imaging Agent for Peritoneal CarcinomatosisREGINO, Celeste Aida S; OGAWA, Mikako; ALFORD, Raphael et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 4, pp 1579-1586, issn 0022-2623, 8 p.Article

Discovery of Cyclic Acylguanidines as Highly Potent and Selective β-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I—Inhibitor Design and ValidationZHAONING ZHU; SUN, Zhong-Yue; WYSS, Daniel F et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 3, pp 951-965, issn 0022-2623, 15 p.Article

Probing Torpedo californica Acetylcholinesterase Catalytic Gorge with Two Novel Bis-functional Galanthamine DerivativesBARTOLUCCI, Cecilia; HALLER, Lars A; JORDIS, Ulrich et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 2, pp 745-751, issn 0022-2623, 7 p.Article

Antagonists of the P2X₇ Receptor. From Lead Identification to Drug DevelopmentGUILE, Simon D; ALCARAZ, Lilian; BIRKINSHAW, Timothy N et al.Journal of medicinal chemistry (Print). 2009, Vol 52, Num 10, pp 3123-3141, issn 0022-2623, 19 p.Article

2-[(2,3-Dihydro-1H-indol-1-yl)methyl]melatonin Analogues : A Novel Class of MT₂-Selective Melatonin Receptor AntagonistsZLOTOS, Darius P; ATTIA, Mohamed I; JULIUS, Justin et al.Journal of medicinal chemistry (Print). 2009, Vol 52, Num 3, pp 826-833, issn 0022-2623, 8 p.Article

5,7,8-Trimethyl-benzopyran and 5,7,8-Trimethyl-1,4-benzoxazine Aminoamide Derivatives as Novel Antiarrhythmics against Ischemia-Reperfusion InjuryKOINI, Eftychia N; PAPAZAFIRI, Panagiota; VASSILOPOULOS, Athanasios et al.Journal of medicinal chemistry (Print). 2009, Vol 52, Num 8, pp 2328-2340, issn 0022-2623, 13 p.Article

A Dihydrobenzofuran Lignan Induces Cell Death by Modulating Mitochondrial Pathway and G2/M Cell Cycle ArrestBOSE, Julie S; GANGAN, Vijay; PRAKASH, Ravi et al.Journal of medicinal chemistry (Print). 2009, Vol 52, Num 10, pp 3184-3190, issn 0022-2623, 7 p.Article