Anti-Influenza Drug Discovery: Structure—Activity Relationship and Mechanistic Insight into Novel Angelicin DerivativesYEH, Jiann-Yih; SELVARAJ COUMAR, Mohane; CHEN, Chi-Jene et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 4, pp 1519-1533, issn 0022-2623, 15 p.Article

Antitrypanosomal Activity of 1,2-Dihydroquinolin-6-ols and Their Ester DerivativesFOTIE, Jean; KAISER, Marcel; WERBOVETZ, Karl A et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 3, pp 966-982, issn 0022-2623, 17 p.Article

Catalysis and Inhibition of Mycobacterium tuberculosis Methionine AminopeptidaseLU, Jing-Ping; CHAI, Sergio C; YE, Qi-Zhuang et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 3, pp 1329-1337, issn 0022-2623, 9 p.Article

Characterization of Tunable Piperidine and Piperazine Carbamates as Inhibitors of Endocannabinoid HydrolasesLONG, Jonathan Z; XIN JIN; ADIBEKIAN, Alexander et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 4, pp 1830-1842, issn 0022-2623, 13 p.Article

Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and ThiocoumarinsMARESCA, Alfonso; TEMPERINI, Claudia; POCHET, Lionel et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 1, pp 335-344, issn 0022-2623, 10 p.Article

Design of O-Acetylserine Sulfhydrylase Inhibitors by Mimicking NatureSALSI, Enea; BAYDEN, Alexander S; RODERICK, Steven L et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 1, pp 345-356, issn 0022-2623, 12 p.Article

Development of (S)-N⁶-2-(4-(Isoquinolin-1-yl)piperazin-1-yl)ethyl-N⁶-propyl-4,5,6, tetrahydrobenzo[d]-thiazole-2,6-diamine and Its Analogue as a D3 Receptor Preferring Agonist: potent in Vivo Activity in Parkinson's Disease Animal ModelsGHOST, Balaram; ANTONIO, Tamara; JUAN ZHEN et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 3, pp 1023-1037, issn 0022-2623, 15 p.Article

Dihydroxyphenylisoindoline Amides as Orally Bioavailable Inhibitors of the Heat Shock Protein 90 (Hsp90) Molecular ChaperoneKUNG, Pei-Pei; BUWEN HUANG; ELLERAAS, Jeff et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 1, pp 499-503, issn 0022-2623, 5 p.Article

Discovery and Clinical Evaluation of 1-{N [2-(Amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a Thrombin Inhibitor with an Oxyguanidine P1 MotifTIANBAO LU; MARKOTAN, Thomas; END, David et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 4, pp 1843-1856, issn 0022-2623, 14 p.Article

Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of CancerSUTHERLIN, Daniel P; SAMPATH, Deepak; HEFFRON, Tim et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 3, pp 1086-1097, issn 0022-2623, 12 p.Article

Exploring Epidermal Growth Factor Receptor (EGFR) Inhibitor Features: The Role of Fused Dioxygenated Rings on the Quinazoline ScaffoldCHILIN, Adriana; CONCONI, Maria Teresa; MARZARO, Giovanni et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 4, pp 1862-1866, issn 0022-2623, 5 p.Article

Multifunctional Antioxidants for the Treatment of Age-Related DiseasesHONGXIA JIN; RANDAZZO, James; PENG ZHANG et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 3, pp 1117-1127, issn 0022-2623, 11 p.Article

New Structures and Bioactivity Properties of Jasplakinolide (Jaspamide) Analogues from Marine SpongesROBINSON, Sarah J; MORINAKA, Brandon I; AMAGATA, Taro et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 4, pp 1651-1661, issn 0022-2623, 11 p.Article

Novel Inhibitors of Dengue Virus Methyltransferase: Discovery by in Vitro-Driven Virtual Screening on a Desktop Computer GridPODVINEC, Michael; SIEW PHENG LIM; SCHMIDT, Tobias et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 4, pp 1483-1495, issn 0022-2623, 13 p.Article

Novel Synthesis of the Hexahydroimidazo[1,5b]isoquinoline Scaffold: Application to the Synthesis of Glucocorticoid Receptor ModulatorsXIAO, Hai-Yun; WU, Dauh-Rurng; MURALI DHAR, T. G et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 3, pp 1270-1280, issn 0022-2623, 11 p.Article

Scope and Difficulty in Generating Theoretical Insights Regarding Ligand Recognition and Activation of the β₂ Adrenergic ReceptorSORIANO-URSUA, Marvin A; TRUJILLO-FERRARA, José G; CORREA-BASURTO, José et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 3, pp 923-932, issn 0022-2623, 10 p.Article

Single Agents with Designed Combination Chemotherapy Potential: Synthesis and Evaluation of Substituted Pyrimido[4,5-b]indoles as Receptor Tyrosine Kinase and Thymidylate Synthase Inhibitors and as Antitumor AgentsGANGJEE, Aleem; ZAWARE, Nilesh; RAGHAVAN, Sudhir et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 4, pp 1563-1578, issn 0022-2623, 16 p.Article

Studies of the Synthesis of All Stereoisomers of MG-132 Proteasome Inhibitors in the Tumor Targeting ApproachMROCZKIEWICZ, Michał; WINKLER, Katarzyna; NOWIS, Dominika et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 4, pp 1509-1518, issn 0022-2623, 10 p.Article

Synthesis and Antimicrobial Evaluation of Amphiphilic Neamine DerivativesBAUSSANNE, Isabelle; BUSSIERE, Antoine; HALDER, Somnath et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 1, pp 119-127, issn 0022-2623, 9 p.Article

Synthesis and Antitumor Activity of a Novel Series of 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolate Inhibitors of Purine Biosynthesis with Selectivity for High Affinity Folate Receptors and the Proton-Coupled Folate Transporter over the Reduced Folate Carrier for Cellular EntryLEI WANG; CHERIAN, Christina; GANGJEE, Aleem et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 3, pp 1306-1318, issn 0022-2623, 13 p.Article

Synthesis and Preclinical Evaluations of 2-(2-Fluorophenyl)-6,7-methylenedioxyquinolin-4-one Monosodium Phosphate (CHM—1—P—Na) as a Potent Antitumor AgentCHOU, Li-Chen; CHEN, Chien-Ting; CHIEN, Du-Shieng et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 4, pp 1616-1626, issn 0022-2623, 11 p.Article

The Permeation of Amphoteric Drugs through Artificial Membranes — An in Combo Absorption Model Based on Paracellular and Transmembrane PermeabilityTAM, Kin Y; AVDEEF, Alex; TSINMAN, Oksana et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 1, pp 392-401, issn 0022-2623, 10 p.Article

The Structure—Activity Relationship of the Antimalarial Ozonide Arterolane (OZ277)YUXIANG DONG; WITTLIN, Sergio; CREEK, Darren J et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 1, pp 481-491, issn 0022-2623, 11 p.Article

Insight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and MutagenesisHUANCHEN WANG; XUAN LUO; MENGCHUN YE et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 4, pp 1726-1731, issn 0022-2623, 6 p.Article

Biomedical Application of Orexin/Hypocretin Receptor Ligands in NeuroscienceBOSS, Christoph; BRISBARE-ROCH, Catherine; JENCK, Francois et al.Journal of medicinal chemistry (Print). 2009, Vol 52, Num 4, pp 891-903, issn 0022-2623, 13 p.Article