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Overcoming the immortality of tumour cells by telomere and telomerase based cancer therapeutics : current status and future prospects. CommentaryKELLAND, Lloyd R.European journal of cancer (1990). 2005, Vol 41, Num 7, issn 0959-8049, 970,971-979 [10 p.]Article

An expeditious synthesis of cytotoxic pyrroloisoquinoline derivatives. Structure-activity comparative studies with isomeric pyrroloquinolinesVLACHOU, Margarita; TSOTINIS, Andrew; KELLAND, Lloyd R et al.European journal of pharmaceutical sciences. 2002, Vol 17, Num 3, pp 139-143, issn 0928-0987, 5 p.Article

Synthesis and antimelanoma activity of analogues of N-acetyl-4-S-cysteaminylphenolLANT, Neil J; MCKEOWN, Paul; KELLAND, Lloyd R et al.Anti-cancer drug design. 2000, Vol 15, Num 4, pp 295-302, issn 0266-9536Article

Amide-Based Prodrugs of Spermidine-Bridged Dinuclear Platinum. Synthesis, DNA Binding, and Biological ActivityHEGMANS, Alexander; KASPARKOVA, Jana; VRANA, Oldrich et al.Journal of medicinal chemistry (Print). 2008, Vol 51, Num 7, pp 2254-2260, issn 0022-2623, 7 p.Article

In vitro prevention of the emergence of multidrug resistance in a pediatric rhabdomyosarcoma cell lineCOCKER, Hilary A; TIFFIN, Nicki; PRITCHARD-JONES, Kathy et al.Clinical cancer research. 2001, Vol 7, Num 10, pp 3193-3198, issn 1078-0432Article

Synthesis and antimelanoma activity of tertiary amide analogues of N-acetyl-4-S-cysteaminylphenolPEARSON, Vikki C; FERGUSON, Jillian; ROGERS, Paul M et al.Oncology research. 2003, Vol 13, Num 11, pp 503-512, issn 0965-0407, 10 p.Article

Establishment and characterization of acquired resistance to the farnesyl protein transferase inhibitor R115777 in a human colon cancer cell lineSMITH, Victoria; ROWLANDS, Martin G; BARRIE, Elaine et al.Clinical cancer research. 2002, Vol 8, Num 6, pp 2002-2009, issn 1078-0432Article

N4-(ω-aminoalkyl)-1-[(ω-aminoalkyl)amino]-4-acridinecarboxamides : Novel, potent, cytotoxic, and DNA-binding agentsANTONINI, Ippolito; POLUCCI, Paolo; KELLAND, Lloyd R et al.Journal of medicinal chemistry (Print). 2000, Vol 43, Num 25, pp 4801-4805, issn 0022-2623Article

Mechanisms of tumor vascular shutdown induced by 5,6-Dimethylxanthenone-4-Acetic Acid (DMXAA) : Increased tumor vascular permeabilityLIANGLI ZHAO; CHING, Lai-Ming; KESTELL, Philip et al.International journal of cancer. 2005, Vol 116, Num 2, pp 322-326, issn 0020-7136, 5 p.Article

Synthesis and antimelanoma activity of sterically congested tertiary amide analogues of N-acetyl-4-S-cysteaminylphenolFERGUSON, Jillian; ROGERS, Paul M; KELLAND, Lloyd R et al.Oncology research. 2005, Vol 15, Num 2, pp 87-94, issn 0965-0407, 8 p.Article

Synthesis and biological evaluation of an N10-Psec substituted pyrrolo[2,1-c][1,4]benzodiazepine prodrugBERRY, Jane M; HOWARD, Philip W; KELLAND, Lloyd R et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 10, pp 1413-1416, issn 0960-894XArticle

ErbB2 overexpression in an ovarian cancer cell line confers sensitivity to the HSP90 inhibitor geldanamycinSMITH, Vicki; HOBBS, Stephen; COURT, William et al.Anticancer research. 2002, Vol 22, Num 4, pp 1993-1999, issn 0250-7005, 7 p.Article

A new class of symmetric bisbenzimidazole-based DNA minor groove-binding agents showing antitumor activityMANN, John; BARON, Anne; OPOKU-BOAHEN, Yaw et al.Journal of medicinal chemistry (Print). 2001, Vol 44, Num 2, pp 138-144, issn 0022-2623Article

Synthesis and antimelanoma activity of reversed amide analogues of N-acetyl-4-S-cysteaminylphenolNICOLL, Kathryn; ROBERTSON, Jane; LANT, Neil et al.Oncology research. 2006, Vol 16, Num 2, pp 97-106, issn 0965-0407, 10 p.Article

SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity. Part 1: Cellular pharmacology, in vitro and initial in vivo antitumor activityHARTLEY, John A; SPANSWICK, Victoria J; HOLLINGSHEAD, Melinda G et al.Cancer research (Baltimore). 2004, Vol 64, Num 18, pp 6693-6699, issn 0008-5472, 7 p.Article

Chemical synthesis and cytotoxicity of dihydroxylated cyclopentenone analogues of Neocarzinostatin chromophoreURBANIAK, Michael D; FROST, Lisa M; BINGHAM, John P et al.Bioorganic & medicinal chemistry letters (Print). 2003, Vol 13, Num 12, pp 2025-2027, issn 0960-894X, 3 p.Article

Synthesis of the first example of a C2-C3/C2'-C3'-endo unsaturated pyrrolo[2,1-c][1,4]benzodiazepine dimerGREGSON, Stephen J; HOWARD, Philip W; CORCORAN, Kathryn E et al.Bioorganic & medicinal chemistry letters (Print). 2001, Vol 11, Num 21, pp 2859-2862, issn 0960-894XArticle

Trisubstituted acridine derivatives as potent and selective telomerase inhibitorsHARRISON, R. John; CUESTA, Javier; WILSON, W. David et al.Journal of medicinal chemistry (Print). 2003, Vol 46, Num 21, pp 4463-4476, issn 0022-2623, 14 p.Article

Antitumor polycyclic acridines. 8. Synthesis and telomerase-inhibitory activity of methylated pentacyclic acridinium saltsHEALD, Robert A; MODI, Chetna; COOKSON, Jenny C et al.Journal of medicinal chemistry (Print). 2002, Vol 45, Num 3, pp 590-597, issn 0022-2623Article

G-quadruplex compounds and cis-platin act synergistically to inhibit cancer cell growth in vitro and in vivoGUNARATNAM, Mekala; GREEN, Colin; MOREIRA, Joao Bruno et al.Biochemical pharmacology. 2009, Vol 78, Num 2, pp 115-122, issn 0006-2952, 8 p.Article

Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agentsMARTINS, Cristina; GUNARATNAM, Mekala; STUART, John et al.Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 8, pp 2293-2298, issn 0960-894X, 6 p.Article

Tumor dose response to the vascular disrupting agent, 5,6-dimethylxanthenone-4-acetic acid, using in vivo magnetic resonance spectroscopyMCPHAIL, Lesley D; CHUNG, Yuen-Li; MADHU, Basetti et al.Clinical cancer research. 2005, Vol 11, Num 10, pp 3705-3713, issn 1078-0432, 9 p.Article

Enhancement of aqueous solubility and stability employing a trans acetate axis in trans planar amine platinum compounds while maintaining the biological profileMA, Erin S. F; BATES, W. Douglas; EDMUNDS, Armistead et al.Journal of medicinal chemistry (Print). 2005, Vol 48, Num 18, pp 5651-5654, issn 0022-2623, 4 p.Article

Synthesis and anti-melanoma activity of analogues of N-acetyl-4-S-cysteaminylphenol substituted with two methyl groups α to the nitrogenLANT, Neil J; MCKEOWN, Paul; TIMONEY, Maire C et al.Anti-cancer drug design. 2001, Vol 16, Num 1, pp 49-55, issn 0266-9536Article

Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicityGREGSON, Stephen J; HOWARD, Philip W; HARTLEY, John A et al.Journal of medicinal chemistry (Print). 2001, Vol 44, Num 5, pp 737-748, issn 0022-2623Article

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