Dipeptide analogues: versatile synthesis of the hydroxyethylene isostereKEMPF, D. J.Journal of organic chemistry. 1986, Vol 51, Num 21, pp 3921-3926, issn 0022-3263Article

NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 proteinHAJDUK, P. J; DINGES, J; HOLZMAN, T. F et al.Journal of medicinal chemistry (Print). 1997, Vol 40, Num 20, pp 3144-3150, issn 0022-2623Article

Human immunodeficiency virus type 1 virions composed of unprocessed Gag and Gag-Pol precursors are capable of reverse transcribing viral genomic RNAKAPLAN, A. H; KROGSTAD, P; KEMPF, D. J et al.Antimicrobial agents and chemotherapy. 1994, Vol 38, Num 12, pp 2929-2933, issn 0066-4804Article

Symmetry-based inhibitors of HIV protease. Structure-activity studies of acylated 2,4-diamino-1,5-diphenyl-3-hydroxypentane and 2,5-diamino-1,6-diphenylhexane-3,4-diolKEMPF, D. J; CODACOVI, L; GREEN, B. E et al.Journal of medicinal chemistry (Print). 1993, Vol 36, Num 3, pp 320-330, issn 0022-2623Article

Potent piperazine hydroxyethylamine HIV protease inhibitors containing novel p3 ligandsXIAOQI CHEN; KEMPF, D. J; MCDONALD, E et al.Bioorganic & medicinal chemistry letters (Print). 1998, Vol 8, Num 24, pp 3531-3536, issn 0960-894XArticle

Metabolism and disposition of the HIV-1 protease inhibitor ritonavir (ABT-538) in rats, dogs, and humansDENISSEN, J. F; GRABOWSKI, B. A; JOHNSON, M. K et al.Drug metabolism and disposition. 1997, Vol 25, Num 4, pp 489-501, issn 0090-9556Article

The β' lithiation of α,β-unsaturated amidesBEAK, P; KEMPF, D. J; WILSON, K. D et al.Journal of the American Chemical Society. 1985, Vol 107, Num 16, pp 4745-4756, issn 0002-7863Article

In vitro metabolism of the HIV-1 protease inhibitor ABT-378: Species comparison and metabolite identificationKUMAR, G. N; JAYANTI, V; KEMPF, D. J et al.Drug metabolism and disposition. 1999, Vol 27, Num 1, pp 86-91, issn 0090-9556Article

Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavirKEMPF, D. J; MARSH, K. C; SUN, E et al.Antimicrobial agents and chemotherapy. 1997, Vol 41, Num 3, pp 654-660, issn 0066-4804Article

Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C₂-symmetric protease inhibitorHO, D. D; TOYOSHIMA, T; HONGMEI MO et al.Journal of virology. 1994, Vol 68, Num 3, pp 2016-2020, issn 0022-538XArticle

Influence of stereochemistry on activity and binding modes for C₂ symmetry-based diol inhibitors of HIV-1 proteaseHOSUR, M. V; BHAT, T. N; KEMPF, D. J et al.Journal of the American Chemical Society. 1994, Vol 116, Num 3, pp 847-855, issn 0002-7863Article

Facile synthesis of potent HIV-1 protease inhibitors containing a novel pseudo-symmetric dipeptide isostereSHAM, H. L; BETEBENNER, D. A; CHEN ZHAO et al.Journal of the Chemical Society. Chemical communications. 1993, Num 13, pp 1052-1053, issn 0022-4936Article

Design, activity, and 2.8 Å crystal structures of a C₂ symmetric inhibitor complexed to HIV-1 proteaseERIKSON, J; NEIDHART, D. J; KOHLBRENNER, W. E et al.Science (Washington, D.C.). 1990, Vol 249, Num 4968, pp 527-533, issn 0036-8075, 7 p.Article

Renin inhibitors based on novel dipeptide analogues. Incorporation of the dehydrohydroxyethylene isostere at the scissile bondKEMPF, D. J; DE LARA, E; STEIN, H. H et al.Journal of medicinal chemistry (Print). 1987, Vol 30, Num 11, pp 1978-1983, issn 0022-2623Article

Progress in the discovery of orally bioavailable inhibitors of HIV proteaseKEMPF, D. J.Perspectives in drug discovery and design. 1995, Vol 2, Num 3, pp 427-436, issn 0928-2866Conference Paper

Synthesis of rigid, heterocyclic dipeptide analoguesKEMPF, D. J; CONDON, S. L.Journal of organic chemistry. 1990, Vol 55, Num 4, pp 1390-1394, issn 0022-3263Article

Ritonavir and saquinavir combination therapy for the treatment of HIV infectionCAMERON, D. W; JAPOUR, A. J; ANGEL, Jon B et al.AIDS (London). 1999, Vol 13, Num 2, pp 213-224, issn 0269-9370Article

The duration of viral suppression during protease inhibitor therapy for HIV-1 infection is predicted by plasma HIV-1 RNA at the nadirKEMPF, D. J; RODE, R. A; LEONARD, J. M et al.AIDS (London). 1998, Vol 12, Num 5, pp F9-F14, issn 0269-9370Article

Lack of stereospecificity in the binding of the P2 amino acid of ritonavir to HIV proteaseKEMPF, D. J; MOLLA, A; WIDEBURG, N. E et al.Bioorganic & medicinal chemistry letters (Print). 1997, Vol 7, Num 6, pp 699-704, issn 0960-894XArticle

Partial inhibition of the human immunodeficiency virus type 1 protease results in aberrant virus assembly and the formation of noninfectious particlesKAPLAN, A. H; ZACK, J. A; KNIGGE, M et al.Journal of virology. 1993, Vol 67, Num 7, pp 4050-4055, issn 0022-538XArticle

Pseudo-symmetrical difluoroketones : highly potent and specific inhibitors of HIV-1 proteaseSHAM, H. L; BETEBENNER, D. A; PLATTNER, J. J et al.FEBS letters. 1993, Vol 329, Num 1-2, pp 144-146, issn 0014-5793Article

Antiviral and pharmacokinetic properties of C₂ symmetries inhibitors of the human immunodeficiency virus type 1 proteaseKEMPF, D. J; MARSH, K. C; WIDEBURG, N. E et al.Antimicrobial agents and chemotherapy. 1991, Vol 35, Num 11, pp 2209-2214, issn 0066-4804Article

Renin inhibitors. Dipeptide analogues of angiotensinogen utilizing a structurally modified phenylalanine residue to impart proteolytic stabilityPLATTNER, J. J; MARCOTTE, P. A; KEMPF, D. J et al.Journal of medicinal chemistry (Print). 1988, Vol 31, Num 12, pp 2277-2288, issn 0022-2623Article