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Protein kinase Cα and ε small-molecule targeted therapeutics : a new roadmap to two Holy Grails in drug discovery?O'BRIAN, Catherine A; FENG CHU; BORNMANN, William G et al.Expert review of anticancer therapy. 2006, Vol 6, Num 2, pp 175-186, issn 1473-7140, 12 p.Article

Synthesis and biological evaluation of new 5-benzylated 4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indoles as PI3Kα inhibitorsBRUEL, Amélie; LOGE, Cedric; RUCHAUD, Sandrine et al.European journal of medicinal chemistry. 2012, Vol 57, pp 225-233, issn 0223-5234, 9 p.Article

Synthesis of N,N'-bis(5-arylidene-4-oxo-3,5-dihydro-4H-imidazol-2-yl)diamines bearing various linkers and biological evaluation as potential inhibitors of kinasesKARIME COULIBALY, Wacothon; PAQUIN, Ludovic; BENIE, Anoubilé et al.European journal of medicinal chemistry. 2012, Vol 58, pp 581-590, issn 0223-5234, 10 p.Article

Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cellsLANXI SONG; TURKSON, James; KARRAS, James G et al.Oncogene (Basingstoke). 2003, Vol 22, Num 27, pp 4150-4165, issn 0950-9232, 16 p.Article

Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitorsBIANCO, Roberto; INCHEOL SHIN; RITTER, Christoph A et al.Oncogene (Basingstoke). 2003, Vol 22, Num 18, pp 2812-2822, issn 0950-9232, 11 p.Article

Hormone-sensitive lipase activity and triacylglycerol hydrolysis are decreased in rat soleus muscle by cyclopiazonic acidWATT, Matthew J; STEINBERG, Gregory R; HEIGENHAUSER, G. J. F et al.American journal of physiology. Endocrinology and metabolism. 2003, Vol 48, Num 2, pp E412-E419, issn 0193-1849Article

Involvement of spinal tyrosine kinase in inflammatory and N-methyl-D-aspartate-induced hyperalgesia in ratsSATO, Eiru; TAKANO, Yoshito; KUNO, Yuichiro et al.European journal of pharmacology. 2003, Vol 468, Num 3, pp 191-198, issn 0014-2999, 8 p.Article

In vitro and In vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202RAYNAUD, Florence I; WHITTAKER, Steven R; VALENTI, Melanie et al.Clinical cancer research. 2005, Vol 11, Num 13, pp 4875-4888, issn 1078-0432, 14 p.Article

Emerging roles of targeted small molecule protein-tyrosine kinase inhibitors in cancer therapySMITH, John K; MAMOON, Naila M; DUHE, Roy J et al.Oncology research. 2004, Vol 14, Num 4-5, pp 175-225, issn 0965-0407, 51 p.Article

Kinase drug discovery approaches in chronic myeloproliferative disordersKUMAR, C; PURANDARE, A. V; LEE, F. Y et al.Oncogene (Basingstoke). 2009, Vol 28, Num 24, pp 2305-2313, issn 0950-9232, 9 p.Article

Myelosuppression and kinase selectivity of multikinase angiogenesis inhibitorsKUMAR, R; CROUTHAMEL, M.-C; ROMINGER, D. H et al.British journal of cancer. 2009, Vol 101, Num 10, pp 1717-1723, issn 0007-0920, 7 p.Article

Molecular Pathways: Resistance to Kinase Inhibitors and Implications for Therapeutic StrategiesLOVLY, Christine M; SHAW, Alice T.Clinical cancer research (Print). 2014, Vol 20, Num 9, pp 2249-2256, issn 1078-0432, 8 p.Article

Nilotinib: A Novel, Selective Tyrosine Kinase InhibitorBLAY, Jean-Yves; VON MEHREN, Margaret.Seminars in oncology. 2011, Vol 38, Num 2, issn 0093-7754, S3-S9, SUP1Article

NilotinibDEININGER, Michael W.Clinical cancer research. 2008, Vol 14, Num 13, pp 4027-4031, issn 1078-0432, 5 p.Article


Synthesis and biological evaluation of N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amines and their pyrido and pyrazino analogues as Ser/Thr kinase inhibitorsLOIDREAU, Yvonnick; MARCHAND, Pascal; DUBOUILH-BENARD, Carole et al.European journal of medicinal chemistry. 2012, Vol 58, pp 171-183, issn 0223-5234, 13 p.Article

Rationale and clinical basis for combining gefitinib (IRESSA, ZD1839) with radiation therapy for solid tumorsOCHS, Judith S.International journal of radiation oncology, biology, physics. 2004, Vol 58, Num 3, pp 941-949, issn 0360-3016, 9 p.Conference Paper

Tyrosine kinase inhibitor STI-571/gleevec down-regulates the β-catenin signaling activityLAN ZHOU; AN, Naili; JAE YOON PARKA et al.Cancer letters. 2003, Vol 193, Num 2, pp 161-170, issn 0304-3835, 10 p.Article

Third-Generation Tyrosine Kinase Inhibitors and BeyondQUINTAS-CARDAMA, Alfonso; KANTARJIAN, Hagop; CORTES, Jorge et al.Seminars in hematology. 2010, Vol 47, Num 4, pp 371-380, issn 0037-1963, 10 p.Article

The function of cyclin-dependent kinase inhibitor p21Cip-1/SDI-1-WAF-1 in chondrogenic differentiationNEGISHI, Yoichi; KAWASHIMA, Kohtaro.Recent research developments in biophysics and biochemistry vol. 4 - 2004 Part I. Recent research developments in biophysics and biochemistry. 2004, pp 175-187, isbn 81-7736-214-3, 13 p.Book Chapter

Design and synthesis of a highly selective, orally active and potent anaplastic lymphoma kinase inhibitor (CH5424802)KINOSHITA, Kazutomo; ASOH, Kohsuke; TSUKAGUCHI, Toshiyuki et al.Bioorganic & medicinal chemistry. 2012, Vol 20, Num 3, pp 1271-1280, issn 0968-0896, 10 p.Article

Tracing pathway activities with kinase inhibitors and reverse phase protein arrays : Analysis of drug effects and actionsVAN OOSTRUM, Jan; CALENDER, Claudio; RECHSTEINER, Daniel et al.Proteomics. Clinical applications (Print). 2009, Vol 3, Num 4, pp 412-422, issn 1862-8346, 11 p.Article

Design and combinatorial synthesis of a novel kinase-focused library using click chemistry-based fragment assemblyIRIE, Takayuki; FUJII, Ikuo; SAWA, Masaaki et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 1, pp 591-596, issn 0960-894X, 6 p.Article

Kinase inhibitors translate lab discoveries into exciting new cures for cancersMOHINDRU, Mani; VERMA, Amit.Indian journal of pediatrics. 2004, Vol 71, Num 8, pp 713-718, issn 0019-5456, 6 p.Article

Optimization and SAR for dual ErbB-1/ErbB-2 tyrosine kinase inhibition in the 6-furanylquinazoline seriesPETROV, Kimberly G; ZHANG, Yue-Mei; WOOD, Edgar R et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 17, pp 4686-4691, issn 0960-894X, 6 p.Article

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