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The active metabolite of leflunomide, A771726, inhibits both the generation of and the bone-resorbing activity of osteoclasts by acting directly on cells of the osteoclast lineageKOBAYASHI, Yukinao; UEYAMA, Seiichi; ARAI, Yoshinori et al.Journal of bone and mineral metabolism (English ed.). 2004, Vol 22, Num 4, pp 318-328, issn 0914-8779, 11 p.Article

New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffoldLOLLI, Marco L; GIORGIS, Marta; TOSCO, Paolo et al.European journal of medicinal chemistry. 2012, Vol 49, pp 102-109, issn 0223-5234, 8 p.Article

Méningite aseptique médicamenteuse induite par le léflunomide = Leflunomide-induced aseptic meningitisCOHEN, Jean David; JORGENSEN, Christian; SANY, Jacques et al.Revue du rhumatisme (Ed. française). 2004, Vol 71, Num 5, pp 412-414, issn 1169-8330, 3 p.Article

Place des traitements d'action lente (DMARD) dans le traitement des spondyloarthrites = Synthetic DMARDs in the treatment of spondyloarthritisWENDTIN, D.La Lettre du rhumatologue. 2013, Num 390, pp 14-17, issn 0761-5027, 4 p.Article

Birth Outcomes in Women Who Have Taken Leflunomide During PregnancyCHAMBERS, Christina D; JOHNSON, Diana L; LYONS JONES, Kenneth et al.Arthritis and rheumatism. 2010, Vol 62, Num 5, pp 1494-1503, issn 0004-3591, 10 p.Article

In vitro metabolism studies on the isoxazole ring scission in the anti-inflammatory agent leflunomide to its active α-cyanoenol metabolite A771726: Mechanistic similarities with the cytochrome P450-catalyzed dehydration of aldoximesKALGUTKAR, Amit S; NGUYEN, Hang T; VAZ, Alfin D. N et al.Drug metabolism and disposition. 2003, Vol 31, Num 10, pp 1240-1250, issn 0090-9556, 11 p.Article

An aggregation sensing reporter identifies leflunomide and teriflunomide as polyglutamine aggregate inhibitorsFUENTEALBA, Rodrigo A; MARASA, Jayne; DIAMOND, Marc I et al.Human molecular genetics (Print). 2012, Vol 21, Num 3, pp 664-680, issn 0964-6906, 17 p.Article

Pregnancy Outcome in Women Exposed to Leflunomide Before or During PregnancyCASSINA, M; JOHNSON, D. L; CHAMBERS, C. D et al.Arthritis and rheumatism. 2012, Vol 64, Num 7, pp 2085-2094, issn 0004-3591, 10 p.Article

Yeast as a model system to elucidate the mechanism of action of drugs: focus on immunosuppressive drug leflunomideFUJIMURA, Hiro-Aki.Recent research developments in applied microbiology and biotechnology (Vol. 1 (2003)). Recent research developments in applied microbiology and biotechnology. 2003, pp 1-10, isbn 81-271-0043-9, 10 p.Book Chapter

Clinical expression of leflunomide-induced pneumonitisCHIKURA, Batsi; LANE, Steven; DAWSON, Julie K et al.Rheumatology (Oxford. Print). 2009, Vol 48, Num 9, pp 1065-1068, issn 1462-0324, 4 p.Article

Efficacy and safety of leflunomide 10 mg versus 20 mg once daily in patients with active rheumatoid arthritis: multinational double-blind, randomized trialPOOR, G; STRAND, V.Rheumatology (Oxford. Print). 2004, Vol 43, Num 6, pp 744-749, issn 1462-0324, 6 p.Article

Leflunomide in the treatment of psoriasis: results of a phase II open trialTLACUILO-PARRA, J. A; GUEVARA-GUTIERREZ, E; RODRIGUEZ-CASTELLANOS, M. A et al.British journal of dermatology (1951). 2004, Vol 150, Num 5, pp 970-976, issn 0007-0963, 7 p.Article

Safety of leflunomide plus infliximab combination therapy in rheumatoid arthritisGODINHO, F; GODFRIN, B; EL MAHOU, S et al.Clinical and experimental rheumatology (Testo stampato). 2004, Vol 22, Num 3, pp 328-330, issn 0392-856X, 3 p.Article

Methotrexate plus leflunomide for the treatment of relapsing Wegener's granulomatosis. A retrospective uncontrolled studyBREMER, J. P; ULLRICH, S; LAUDIEN, M et al.Clinical and experimental rheumatology (Testo stampato). 2010, Vol 28, Num 1, issn 0392-856X, S67-S71, SUP57Article

Les traitements médicamenteux (hors biothérapie) dans la prise en charge de patients atteints de rhumatisme psoriasique périphérique : élaboration de recommandations pour la pratique clinique, à partir d'une analyse systématique de la littérature et de l'opinion d'experts = Pharmacological treatment (biotherapy excluded) of peripheral psoriatic arthritis : development of recommendations for clinical practice based on data from the literature and experts opinionDERNIS, Emmanuelle; LAVIE, Frédéric; GAUDIN, Philippe et al.Revue du rhumatisme (Ed. française). 2007, Vol 74, issn 1169-8330, S31-S38, SUP2Conference Paper

Erythema multiforme-like drug eruption with oral involvement after intake of leflunomideFISCHER, Tobias W; BAUER, Heike I; GRAEFE, Tim et al.Dermatology (Basel). 2003, Vol 207, Num 4, pp 386-389, issn 1018-8665, 4 p.Article

Determination of leflunomide in tablets by high performance liquid chromatographyYENICELI, Duygu; DOGRUKOL-AK, Dilek; TUNCEL, Muzaffer et al.Journal of pharmaceutical and biomedical analysis. 2006, Vol 40, Num 1, pp 197-201, issn 0731-7085, 5 p.Article

Suppressive effect of combination treatment of leflunomide and methotrexate on chemokine expression in patients with rheumatoid arthritisHO, C. Y; WONG, C. K; LI, E. K et al.Clinical and experimental immunology (Print). 2003, Vol 133, Num 1, pp 132-138, issn 0009-9104, 7 p.Article

Cost effectiveness of adding leflunomide to a 5-year strategy of conventional disease-modifying antirheumatic drugs in patients with rheumatoid arthritisMAETZEL, Andreas; STRAND, Vibeke; TUGWELL, Peter et al.Arthritis care and research. 2002, Vol 47, Num 6, pp 655-661, issn 0893-7524, 7 p.Article

Leflunomide Inhibition of BK Virus Replication in Renal Tubular Epithelial CellsBERNHOFF, Eva; TYLDEN, Garth D; KJERPESETH, Lars J et al.Journal of virology. 2010, Vol 84, Num 4, pp 2150-2156, issn 0022-538X, 7 p.Article

Inhibition of tumour necrosis factor and IL-17 production by leflunomide involves the JAK/STAT pathwayGONZALEZ-ALVARO, I; ORTIZ, A. M; DOMINGUEZ-JIMENEZ, C et al.Annals of the rheumatic diseases. 2009, Vol 68, Num 10, pp 1644-1650, issn 0003-4967, 7 p.Article

The immunosuppressive drug leflunomide affects mating-pheromone response and sporulation by different mechanisms in Saccharomyces cerevisiaeFUJIMURA, Hiro-Aki.FEMS microbiology letters. 2000, Vol 191, Num 1, pp 57-60, issn 0378-1097Article

Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexateSTRAND, V; COHEN, S; CALDWELL, J et al.Archives of internal medicine (1960). 1999, Vol 159, Num 21, pp 2542-2550, issn 0003-9926Article

Leflunomide, a novel immunomodulator for the treatment of active rheumatoid arthritisGOLDENBERG, M. M.Clinical therapeutics. 1999, Vol 21, Num 11, pp 1837-1852, issn 0149-2918Article

In vivo effects of leflunomide on normal pancreatic islet and syngeneic islet graft functionGUO, Z; CHONG, A. S. F; SHEN, J et al.Transplantation. 1997, Vol 63, Num 5, pp 716-721, issn 0041-1337Article

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