Discovery of N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a Selective and Orally Efficacious Inhibitor of the Met Kinase SuperfamilySCHROEDER, Gretchen M; YONGMI AN; HUNT, John T et al.Journal of medicinal chemistry (Print). 2009, Vol 52, Num 5, pp 1251-1254, issn 0022-2623, 4 p.Article

Inhibitors of human mitotic kinesin Eg5 : Characterization of the 4-phenyl-tetrahydroisoquinoline lead seriesTARBY, Christine M; KALTENBACH, Robert F; FAIRCHILD, Craig R et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 8, pp 2095-2100, issn 0960-894X, 6 p.Article

The structure of dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutantsTOKARSKI, John S; NEWITT, John A; DIANLIN XIE et al.Cancer research (Baltimore). 2006, Vol 66, Num 11, pp 5790-5797, issn 0008-5472, 8 p.Article

Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737), an in vivo active potent VEGFR-2 inhibitorRUEL, Réjean; THIBEAULT, Carl; HUNT, John T et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 9, pp 2985-2989, issn 0960-894X, 5 p.Article

Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarialsBENDALE, Pravin; OLEPU, Srinivas; FLOYD, David et al.Journal of medicinal chemistry (Print). 2007, Vol 50, Num 19, pp 4585-4605, issn 0022-2623, 21 p.Article

Discovery and evaluation of N-cyclopropyl-2,4-difluoro-5-(2-(pyridin-2-ylamino)thiazol-5-ylmethyl)aminobenzamide (BMS-605541), a selective and orally efficacious inhibitor of vascular endothelial growth factor receptor-2BORZILLERI, Robert M; BHIDE, Rajeev S; MARATHE, Punit et al.Journal of medicinal chemistry (Print). 2006, Vol 49, Num 13, pp 3766-3769, issn 0022-2623, 4 p.Article

Discovery of orally active pyrrolopyridine-and aminopyridine-based Met kinase inhibitorsCAI, Zhen-Wei; WEI, Donna; SACK, John S et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 11, pp 3224-3229, issn 0960-894X, 6 p.Article

Identification of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of Met kinaseSCHROEDER, Gretchen M; CHEN, Xiao-Tao; HUYNH, Tram et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 6, pp 1945-1951, issn 0960-894X, 7 p.Article

Design, synthesis, and evaluation of orally active 4-(2,4-difluoro-5-(methoxycarbamoyl)phenylamino)pyrrolo[2,1-f][1,2,4]triazines as dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 inhibitorsBORZILLERI, Robert M; XIAOPING ZHENG; KAMATH, Amrita et al.Journal of medicinal chemistry (Print). 2005, Vol 48, Num 12, pp 3991-4008, issn 0022-2623, 18 p.Article

Apoptotic and cytostatic farnesyltransferase inhibitors have distinct pharmacology and efficacy profiles in tumor modelsMANNE, Veeraswamy; LEE, Francis Y. F; TAI WAI WONG et al.Cancer research (Baltimore). 2004, Vol 64, Num 11, pp 3974-3980, issn 0008-5472, 7 p.Article

Pyrrolo[1,2-f]triazines as JAK2 inhibitors: Achieving potency and selectivity for JAK2 over JAK3HARIKRISHNAN, Lalgudi S; KAMAU, Muthoni G; POSS, Michael A et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 5, pp 1425-1428, issn 0960-894X, 4 p.Article

Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitorsWILLIAMS, David K; CHEN, Xiao-Tao; HENLEY, Benjamin J et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 9, pp 2998-3002, issn 0960-894X, 5 p.Article

Discovery of Pyrrolopyridine-Pyridone Based Inhibitors of Met Kinase : Synthesis, X-ray Crystallographic Analysis, and Biological ActivitiesKYOUNG SOON KIM; LIPING ZHANG; YONGMI AN et al.Journal of medicinal chemistry (Print). 2008, Vol 51, Num 17, pp 5330-5341, issn 0022-2623, 12 p.Article

Metabolism of 5-lsopropyl-6-(5-methyl-1 ,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737) : Identification of an Unusual N-Acetylglucosamine Conjugate in the Cynomolgus MonkeyJOHNSON, Benjamin M; KAMATH, Amrita V; SHU, Yue-Zhong et al.Drug metabolism and disposition. 2008, Vol 36, Num 12, pp 2475-2483, issn 0090-9556, 9 p.Article

Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein famesyltransferaseVAN VOORHIS, Wesley C; RIVAS, Kasey L; VERLINDE, Christophe L. M. J et al.Antimicrobial agents and chemotherapy. 2007, Vol 51, Num 10, pp 3659-3671, issn 0066-4804, 13 p.Article

Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitorsKYOUNG SOON KIM; SONGFENG LU; WILLIAMS, David K et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 15, pp 3937-3942, issn 0960-894X, 6 p.Article

Discovery of N-(2-chloro-6-methylphenyl)-2-6-(4-(2-hydroxyethyl)-piperazin-1-yl)-2-methylpyr imidin-4-ylaminothiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assaysLOMBARDO, Louis J; LEE, Francis Y; FAIRCHILD, Craig et al.Journal of medicinal chemistry (Print). 2004, Vol 47, Num 27, pp 6658-6661, issn 0022-2623, 4 p.Article