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In vitro metabolism studies on the isoxazole ring scission in the anti-inflammatory agent leflunomide to its active α-cyanoenol metabolite A771726: Mechanistic similarities with the cytochrome P450-catalyzed dehydration of aldoximesKALGUTKAR, Amit S; NGUYEN, Hang T; VAZ, Alfin D. N et al.Drug metabolism and disposition. 2003, Vol 31, Num 10, pp 1240-1250, issn 0090-9556, 11 p.Article

An aggregation sensing reporter identifies leflunomide and teriflunomide as polyglutamine aggregate inhibitorsFUENTEALBA, Rodrigo A; MARASA, Jayne; DIAMOND, Marc I et al.Human molecular genetics (Print). 2012, Vol 21, Num 3, pp 664-680, issn 0964-6906, 17 p.Article

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Clinical Analysis of Chinese Patients With Rheumatoid Arthritis Treated With Leflunomide and Methotrexate Combined With Different Dosages of GlucocorticoidDING, Cong-Zhu; YAO YAO; FENG, Xue-Bing et al.Current therapeutic research. 2012, Vol 73, Num 4-5, pp 123-133, issn 0011-393X, 11 p.Article

Ritonavir―induced lipoatrophy and dyslipidaemia is reversed by the anti-inflammatory drug leflunomide in a PPAR-y-dependent mannerMENCARELLI, Andrea; FRANCISCI, Daniela; RENGA, Barbara et al.Antiviral therapy (London). 2012, Vol 17, Num 4, pp 669-678, issn 1359-6535, 10 p.Article

Rheumatoid Arthritis and Pregnancy: Safety Considerations in Pharmacological ManagementMAKOL, Ashima; WRIGHT, Kerry; AMIN, Shreyasee et al.Drugs (Basel). 2011, Vol 71, Num 15, pp 1973-1987, issn 0012-6667, 15 p.Article

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Microarray analysis of Leflunomide-induced limb malformations in CD-1 miceFUKUSHIMA, Ryou; KANETO, Masako; KITAGAWA, Hiroshi et al.Reproductive toxicology (Elmsford, NY). 2010, Vol 29, Num 1, pp 42-48, issn 0890-6238, 7 p.Article

Clinical expression of leflunomide-induced pneumonitisCHIKURA, Batsi; LANE, Steven; DAWSON, Julie K et al.Rheumatology (Oxford. Print). 2009, Vol 48, Num 9, pp 1065-1068, issn 1462-0324, 4 p.Article

Inhibition of tumour necrosis factor and IL-17 production by leflunomide involves the JAK/STAT pathwayGONZALEZ-ALVARO, I; ORTIZ, A. M; DOMINGUEZ-JIMENEZ, C et al.Annals of the rheumatic diseases. 2009, Vol 68, Num 10, pp 1644-1650, issn 0003-4967, 7 p.Article

Involvement of Breast Cancer Resistance Protein Expression on Rheumatoid Arthritis Synovial Tissue Macrophages in Resistance to Methotrexate and LeflunomideVAN DER HEIJDEN, Joost W; OERLEMANS, Ruud; JANSEN, Gerrit et al.Arthritis and rheumatism. 2009, Vol 60, Num 3, pp 669-677, issn 0004-3591, 9 p.Article

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Genetic polymorphism of CYP1A2 and the toxicity of leflunomide treatment in rheumatoid arthritis patientsBOHANEC GRABAR, Petra; ROZMAN, Blaz; TOMSIC, Matija et al.European journal of clinical pharmacology. 2008, Vol 64, Num 9, pp 871-876, issn 0031-6970, 6 p.Article

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Treatment of Crohn's Disease with Leflunomide as Second-Line Immunosuppression : A Phase 1 Open-Label Trial on Efficacy, Tolerability and SafetyHOLTMANN, Martin H; GERTS, Anna-Lena; WEINMAN, Arndt et al.Digestive diseases and sciences. 2008, Vol 53, Num 4, pp 1025-1032, issn 0163-2116, 8 p.Article

Limited efficacy of conventional DMARDs after initial methotrexate failure in patients with recent onset rheumatoid arthritis treated according to the disease activity scoreVAN DER KOOIJ, Sjoerd M; DE VRIES-BOUWSTRA, Jeska K; DIJKMANS, Ben A. C et al.Annals of the rheumatic diseases. 2007, Vol 66, Num 10, pp 1356-1362, issn 0003-4967, 7 p.Article

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