Attenuation of the development of morphine dependence/tolerance by nefiracetam : involvement of adenosine 3' :5'-cyclic monophosphate systemITOH, Akio; SHIOTANI, Tadashi; NAKAYAMA, Shinobu et al.Behavioural brain research. 2000, Vol 115, Num 1, pp 65-74, issn 0166-4328Article

Investigation of testicular toxicity of nefiracetam, a neurotransmission enhancer, in ratsSHIMADA, Makoto; SHIKANAI, Yukari; SHIMOMURA, Kazuhiro et al.Toxicology letters. 2003, Vol 143, Num 3, pp 307-315, issn 0378-4274, 9 p.Article

Anticonvulsant properties of the novel nootropic agent nefiracetam in seizure models of mice and ratsKITANO, Yutaka; KOMIYAMA, Chika; MAKINO, Mitsuhiro et al.Epilepsia (Copenhagen). 2005, Vol 46, Num 6, pp 811-818, issn 0013-9580, 8 p.Article

Testicular toxicity induced in dogs by nefiracetam, a neutrotransmission enhancerSHIMOMURA, Kazuhiro; SHIMADA, Makoto; HAGIWARA, Miyoko et al.Reproductive toxicology (Elmsford, NY). 2004, Vol 18, Num 3, pp 423-430, issn 0890-6238, 8 p.Article

Effects of nefiracetam, a novel pyrrolidone-type nootropic agent, on the amygdala-kindled seizures in ratsKITANO, Yutaka; KOMIYAMA, Chika; MAKINO, Mitsuhiro et al.Epilepsia (Copenhagen). 2005, Vol 46, Num 10, pp 1561-1568, issn 0013-9580, 8 p.Article

Nefiracetam metabolism by human liver microsomes: role of cytochrome P450 3A4 and cytochrome P450 1A2 in 5-hydroxynefiracetam formationFUJIMAKI, Yuko; ARAI, Nobuko; NAKAZAWA, Tsunenori et al.Journal of pharmacy and pharmacology. 2001, Vol 53, Num 6, pp 795-804, issn 0022-3573Article

Nefiracetam elevates extracellular acetylcholine level in the frontal cortex of rats with cerebral cholinergic dysfunctions : an in vivo microdialysis studySAKURAI, T; KATO, T; MORI, K et al.Neuroscience letters. 1998, Vol 246, Num 2, pp 69-72, issn 0304-3940Article

Effects of nefiracetam on amnesia animal models with neuronal dysfunctionsHIRAMATSU, M; SHIOTANI, T; KAMEYAMA, T et al.Behavioural brain research. 1997, Vol 83, Num 1-2, pp 107-115, issn 0166-4328Conference Paper

Nefiracetam induces a long-lasting facilitation of hippocampal postsynaptic responses in mice lacking the NMDA receptor ∈1 subunitMATSUMOTO, Shinji; KANNO, Takeshi; NOMURA, Tamotsu et al.Brain research. 2002, Vol 956, Num 1, pp 178-181, issn 0006-8993, 4 p.Article

Improvement of depressive behaviors by nefiracetam is associated with activation of CaM kinases in olfactory bulbectomized miceFENG HAN; NAKANO, Tetsuo; YAMAMOTO, Yui et al.Brain research. 2009, Vol 1265, pp 205-214, issn 0006-8993, 10 p.Article

Basic science and epilepsy: Experimental epilepsy surgeryTANAKA, Tatsuya; HASHIZUME, Kiyotaka; SAWAMURA, Atsushi et al.Stereotactic and functional neurosurgery. 2002, Vol 77, Num 1-4, pp 239-244, issn 1011-6125Conference Paper

Antiepileptic effect of nefiracetam on kainic acid-induced limbic seizure in ratsHASHIZUME, K; KUNIMOTO, M; MAEDA, T et al.Epilepsy research. 2000, Vol 39, Num 3, pp 221-228, issn 0920-1211Article

A 'long-term-potentiation-like' facilitation of hippocampal synaptic transmission induced by the nootropic nefiracetamNISHIZAKI, T; MATSUOKA, T; NOMURA, T et al.Brain research. 1999, Vol 826, Num 2, pp 281-288, issn 0006-8993Article

Cellular mechanisms underlying cognition-enhancing actions of nefiracetam (DM-9384)YOSHII, M; WATABE, S; SAKURAI, T et al.Behavioural brain research. 1997, Vol 83, Num 1-2, pp 185-188, issn 0166-4328Conference Paper

Nefiracetam facilitates hippocampal neurotransmission by a mechanism independent of the piracetam and aniracetam actionNOMURA, T; NISHIZAKI, T.Brain research. 2000, Vol 870, Num 1-2, pp 157-162, issn 0006-8993Article

Anticonvulsant actions of nefiracetam on epileptic EL mice and their relation to peripheral-type benzodiazepine receptorsSHIOTANI, T; NAKAMOTO, Y; WATABE, S et al.Brain research. 2000, Vol 859, Num 2, pp 255-261, issn 0006-8993Article

Investigation on urinary proteins and renal mRNA expression in canine renal papillary necrosis induced by nefiracetamTSUCHIYA, Yoshimi; TOMINAGA, Yuri; MATSUBAYASHI, Kyuichi et al.Archives of toxicology. 2005, Vol 79, Num 9, pp 500-507, issn 0340-5761, 8 p.Article

Nefiracetam and physostigmine: separate and combined effects on learning in older rabbitsWOODRUFF-PAK, Diana S; EWERS, Michael; SHIOTANI, Tadashi et al.Neurobiology of aging. 2004, Vol 25, Num 6, pp 807-816, issn 0197-4580, 10 p.Article

The cognition-enhancer nefiracetam is protective in BDNF-independent neuronal cell death under the serum-free conditionFUJITA, Ryousuke; TAKAYAMA, Naoko; UEDA, Hiroshi et al.Neurochemistry international. 2002, Vol 40, Num 2, pp 139-143, issn 0197-0186Article

The anti-dementia drug nefiracetam facilitates hippocampal synaptic transmission by functionally targeting presynaptic nicotinic ACh receptorsNISHIZAKI, T; NOMURA, T; MATUOKA, T et al.Molecular brain research. 2000, Vol 80, Num 1, pp 53-62, issn 0169-328XArticle

Nefiracetam improves Morris water maze performance following traumatic brain injury in ratsDEFORD, S. Michelle; WILSON, Margaret S; GIBSON, Cynthia J et al.Pharmacology, biochemistry and behavior. 2001, Vol 69, Num 3-4, pp 611-616, issn 0091-3057Article

Mecamylamine, or scopolamine-induced learning impairment : ameliorated by nefiracetamWOODRUFF-PAK, D. S; HINCHLIFFE, R. M.Psychopharmacologia. 1997, Vol 131, Num 2, pp 130-139, issn 0033-3158Article

Mutagenicity study of the new cognition-enhancing agent nefiracetamSHIMADA, H; HATTORI, C; TANAKA, N et al.Arzneimittel-Forschung. 1994, Vol 44, Num 2A, pp 251-253, issn 0004-4172Article

Discriminative-stimulus effects of methamphetamine and morphine in rats are attenuated by cAMP-related compoundsYIJIN YAN; NITTA, Atsumi; MIZUNO, Tomoko et al.Behavioural brain research. 2006, Vol 173, Num 1, pp 39-46, issn 0166-4328, 8 p.Article

A therapeutic strategy to prevent morphine dependence and tolerance by coadministration of cAMP-related reagents with morphineITOH, A; NODA, Y; MAMIYA, T et al.Methods and findings in experimental and clinical pharmacology. 1998, Vol 20, Num 7, pp 619-625, issn 0379-0355Conference Paper