Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines : From anti-pestivirus to anti-hepatitis C virus activityPUERSTINGER, Gerhard; PAESHUYSE, Jan; DE CLERCQ, Erik et al.Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 2, pp 390-393, issn 0960-894X, 4 p.Article

Ribavirin antagonizes the in vitro anti-hepatitis C virus activity of 2'-C-methylcytidine, the active component of valopicitabineCOELMONT, Lotte; PAESHUYSE, Jan; WINDISCH, Marc P et al.Antimicrobial agents and chemotherapy. 2006, Vol 50, Num 10, pp 3444-3446, issn 0066-4804, 3 p.Article

Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines : A new class of pestivirus inhibitorsPUERSTINGER, Gerhard; PAESHUYSE, Jan; HERDEWIJN, Piet et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 20, pp 5345-5349, issn 0960-894X, 5 p.Article

Substituted 2,6-bis(benzimidazol-2-yl)pyridines: A novel chemical class of pestivirus inhibitors that targets a hot spot for inhibition of pestivirus replication in the RNA-dependent RNA polymeraseMUSIU, Simone; PÜRSTINGER, Gerhard; STALLINGER, Sylvia et al.Antiviral research. 2014, Vol 106, pp 71-79, issn 0166-3542, 9 p.Article

Synthesis and antiviral activity of an imidazo[1,2-a]pyrrolo[2,3-c]pyridine series against the bovine viral diarrhea virusCHEZAL, Jean-Michel; PAESHUYSE, Jan; NEYTS, Johan et al.European journal of medicinal chemistry. 2010, Vol 45, Num 5, pp 2044-2047, issn 0223-5234, 4 p.Article

Highly potent and selective inhibition of bovine viral diarrhea virus replication by γ-carboline derivativesSALIM, Mohammed T. A; GOTO, Yukinori; HERDEWIJN, Piet et al.Antiviral research. 2010, Vol 88, Num 3, pp 263-268, issn 0166-3542, 6 p.Article

Debio 025, a Cydophilin Binding Molecule, Is Highly Efficient in Clearing Hepatitis C Virus (HCV) Replicon-Containing Cells When Used Alone or in Combination with Specifically Targeted Antiviral Therapy for HCV (STAT-C) InhibitorsCOELMONT, Lotte; KAPTEIN, Suzanne; PAESHUYSE, Jan et al.Antimicrobial agents and chemotherapy. 2009, Vol 53, Num 3, pp 967-976, issn 0066-4804, 10 p.Article

Inhibition of Subgenomic Hepatitis C Virus RNA Replication by Acridone Derivatives: Identification of an NS3 Helicase InhibitorMANFRONI, Giuseppe; PAESHUYSE, Jan; MASSARI, Serena et al.Journal of medicinal chemistry (Print). 2009, Vol 52, Num 10, pp 3354-3365, issn 0022-2623, 12 p.Article

Proof of concept for the reduction of classical swine fever infection in pigs by a novel viral polymerase inhibitorVRANCKEN, Robert; HAEGEMAN, Andy; PAESHUYSE, Jan et al.Journal of general virology. 2009, Vol 90, pp 1335-1342, issn 0022-1317, 8 p., 6Article

Substituted imidazopyridines as potent inhibitors of HCV replicationVLIEGEN, Inge; PAESHUYSE, Jan; OARE, David et al.Journal of hepatology. 2009, Vol 50, Num 5, pp 999-1009, issn 0168-8278, 11 p.Article

Human pluripotent stem cell-derived hepatocytes support complete replication of hepatitis C virusROELANDT, Philip; OBEID, Susan; PAESHUYSE, Jan et al.Journal of hepatology. 2012, Vol 57, Num 2, pp 246-251, issn 0168-8278, 6 p.Article

Preclinical Characterization of Naturally Occurring Polyketide Cyclophilin Inhibitors from the Sanglifehrin FamilyGREGORY, Matthew A; BOBARDT, Michael; NUR-E-ALAM, Mohammad et al.Antimicrobial agents and chemotherapy. 2011, Vol 55, Num 5, pp 1975-1981, issn 0066-4804, 7 p.Article

The imidazopyrrolopyridine analogue AG110 is a novel, highly selective inhibitor of pestiviruses that targets the viral RNA-dependent RNA polymerase at a hot spot for inhibition of viral replicationPAESHUYSE, Jan; CHEZAL, Jean-Michel; KOENEN, Frank et al.Journal of virology. 2007, Vol 81, Num 20, pp 11046-11053, issn 0022-538X, 8 p.Article

A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerasePAESHUYSE, Jan; LEYSSEN, Pieter; LETELLIER, Carine et al.Journal of virology. 2006, Vol 80, Num 1, pp 149-160, issn 0022-538X, 12 p.Article

Impact of direct virus-induced neuronal dysfunction and immunological damage on the progression of flavivirus (Modoc) encephalitis in a murine modelLEYSSEN, Pieter; PAESHUYSE, Jan; CHARLIER, Nathalie et al.Journal of neurovirology. 2003, Vol 9, Num 1, pp 69-78, issn 1355-0284, 10 p.Article

Mechanistic Characterization of GS-9190 (Tegobuvir), a Novel Nonnucleoside Inhibitor of Hepatitis C Virus NS5B PolymeraseSHIH, I-Hung; VLIEGEN, Inge; XIAOPING QI et al.Antimicrobial agents and chemotherapy. 2011, Vol 55, Num 9, pp 4196-4203, issn 0066-4804, 8 p.Article

A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerasePAESHUYSE, Jan; LETELLIER, Carine; PUERSTINGER, Gerhard et al.Antiviral research. 2009, Vol 82, Num 3, pp 141-147, issn 0166-3542, 7 p.Article

Statins Potentiate the In Vitro Anti-Hepatitis C Virus Activity of Selective Hepatitis C Virus Inhibitors and Delay or Prevent Resistance DevelopmentDELANG, Leen; PAESHUYSE, Jan; VLIEGEN, Inge et al.Hepatology (Baltimore, Md.). 2009, Vol 50, Num 1, pp 6-16, issn 0270-9139, 11 p.Article

Synthesis and anti-BVDV activity of acridones as new potential antiviral agentsTABARRINI, Oriana; MANFRONI, Giuseppe; NEYTS, Johan et al.Journal of medicinal chemistry (Print). 2006, Vol 49, Num 8, pp 2621-2627, issn 0022-2623, 7 p.Article