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A simple method for differentiation of monoisotopic drug metabolites with hydrogen-deuterium exchange liquid chromatography/electrospray mass spectrometryTOLONEN, Ari; TURPEINEN, Miia; UUSITALO, Jouko et al.European journal of pharmaceutical sciences. 2005, Vol 25, Num 1, pp 155-162, issn 0928-0987, 8 p.Article

In Vivo-In Vitro-In Silico Pharmacokinetic Modelling in Drug Development: Current Status and Future DirectionsPELKONEN, Olavi; TURPEINEN, Miia; RAUNIO, Hannu et al.Clinical pharmacokinetics. 2011, Vol 50, Num 8, pp 483-491, issn 0312-5963, 9 p.Article

Cytochrome P450 and gene activation-from pharmacology to cholesterol elimination and regression of atherosclerosis. CommentaryPELKONEN, Olavi; HAKKOLA, Jukka; LUOMA, Pauli V et al.European journal of clinical pharmacology. 2008, Vol 64, Num 9, pp 837-850, issn 0031-6970, 14 p.Article

In vitro metabolism and interaction of profenofos by human, mouse and rat liver preparationsABASS, Khaled; REPONEN, Petri; JALONEN, Jorma et al.Pesticide biochemistry and physiology (Print). 2007, Vol 87, Num 3, pp 238-247, issn 0048-3575, 10 p.Article

Expression and regulation of xenobiotic-metabolizing cytochrome P450 (CYP) enzymes in human lungHUKKANEN, Janne; PELKONEN, Olavi; HAKKOLA, Jukka et al.Critical reviews in toxicology. 2002, Vol 32, Num 5, pp 391-411, issn 1040-8444, 21 p.Article

Polymorphisms of CYP2A6 and its practical consequencesRAUNIO, Hannu; RAUTIO, Arja; GULLSTEN, Harriet et al.British journal of clinical pharmacology. 2001, Vol 52, Num 4, pp 357-363, issn 0306-5251Article

An evaluation of the cytochrome P450 inhibition potential of selected pesticides in human hepatic microsomesABASS, Khaled; TURPEINEN, Miia; PELKONEN, Olavi et al.Journal of environmental science and health. Part B. Pesticides, food contaminants, and agricultural wastes. 2009, Vol 44, Num 6, pp 553-563, issn 0360-1234, 11 p.Article

Liquid chromatography-mass spectrometry in in vitro drug metabolite screeningTOLONEN, Ari; TURPEINEN, Miia; PELKONEN, Olavi et al.Drug discovery today. 2009, Vol 14, Num 3-4, pp 120-133, issn 1359-6446, 14 p.Article

Analysis of nine drugs and their cytochrome P450-specific probe metabolites from urine by liquid chromatography-tandem mass spectrometry utilizing sub 2 μm particle size columnPETSALO, Aleksanteri; TURPEINEN, Miia; PELKONEN, Olavi et al.Journal of chromatography. 2008, Vol 1215, Num 1-2, pp 107-115, issn 0021-9673, 9 p.Article

Human CYPs: In vivo and clinical aspectsPELKONEN, Olavi.Drug metabolism reviews (Softcover ed.). 2002, Vol 34, Num 1-2, pp 37-46, issn 0360-2532Article

In vitro inhibition of cytochrome P450 enzymes in human liver microsomes by a potent CYP2A6 inhibitor, trans-2-phenylcyclopropylamine (tranylcypromine), and its nonamine analog, cyclopropylbenzeneTAAVITSAINEN, Päivi; JUVONEN, Risto; PELKONEN, Olavi et al.Drug metabolism and disposition. 2001, Vol 29, Num 3, pp 217-222, issn 0090-9556Article

Marked effect of liver and kidney function on the pharmacokinetics of selegilineANTTILA, Markku; SOTANIEMI, Eero A; PELKONEN, Olavi et al.Clinical pharmacology and therapeutics. 2005, Vol 77, Num 1, pp 54-62, issn 0009-9236, 9 p.Article

Metabolism of Ophthalmic Timolol: New Aspects of an Old DrugVOLOTINEN, Marjo; HAKKOLA, Jukka; PELKONEN, Olavi et al.Basic & clinical pharmacology & toxicology (Print). 2011, Vol 108, Num 5, pp 297-303, issn 1742-7835, 7 p.Article

Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindroneKORHONEN, Tuomas; TURPEINEN, Miia; TOLONEN, Ari et al.Journal of steroid biochemistry and molecular biology. 2008, Vol 110, Num 1-2, pp 56-66, issn 0960-0760, 11 p.Article

Characterization of diuron N-demethylation by mammalian hepatic microsomes and cDNA-expressed human cytochrome P450 enzymesABASS, Khaled; REPONEN, Petri; TURPEINEN, Miia et al.Drug metabolism and disposition. 2007, Vol 35, Num 9, pp 1634-1641, issn 0090-9556, 8 p.Article

In vitro interaction cocktail assay for nine major cytochrome P450 enzymes with 13 probe reactions and a single LC/MSMS run : analytical validation and testing with monoclonal anti-CYP antibodiesTOLONEN, Ari; PETSALO, Aleksanteri; TURPEINEN, Miia et al.Journal of mass spectrometry. 2007, Vol 42, Num 7, pp 960-966, issn 1076-5174, 7 p.Article

Prediction of drug metabolism and interactions on the basis of in vitro investigationsPELKONEN, Olavi; TURPEINEN, Miia; UUSITALO, Jouko et al.Basic & clinical pharmacology & toxicology (Print). 2005, Vol 96, Num 3, pp 167-175, issn 1742-7835, 9 p.Article

Inhibition of cytochrome P450 2B6 activity by hormone replacement therapy and oral contraceptive as measured by bupropion hydroxylationPALOVAARA, Sanna; PELKONEN, Olavi; UUSITALO, Jouko et al.Clinical pharmacology and therapeutics. 2003, Vol 74, Num 4, pp 326-333, issn 0009-9236, 8 p.Article

Estimation of health risk by using toxicokinetic modelling: A case study of polychlorinated biphenyl PCB153ABASS, Khaled; HUUSKO, Antti; NIEMINEN, Pentti et al.Journal of hazardous materials (Print). 2013, Vol 261, pp 1-10, issn 0304-3894, 10 p.Article

Effects of Selective Serotonin Reuptake Inhibitors on Timolol Metabolism in Human Liver Microsomes and Cryo-Preserved HepatocytesVOLOTINEN, Marjo; KORJAMO, Timo; TOLONEN, Ari et al.Basic & clinical pharmacology & toxicology (Print). 2010, Vol 106, Num 4, pp 302-309, issn 1742-7835, 8 p.Article

Ospemifene metabolism in humans in vitro and in vivo: metabolite identification, quantitation, and CYP assignment of major hydroxylationsTOLONEN, Ari; KOSKIMIES, Pasi; TURPEINEN, Miia et al.Drug metabolism and drug interactions. 2013, Vol 28, Num 3, pp 153-161, issn 0792-5077, 9 p.Article

Metabolic and efflux properties of caco-2 cells stably transfected with nuclear receptorsKORJAMO, Timo; MÖNKKÖNEN, Jukka; UUSITALO, Jouko et al.Pharmaceutical research. 2006, Vol 23, Num 9, pp 1991-2001, issn 0724-8741, 11 p.Article

Placental transfer and DNA binding of benzo(a)pyrene in human placental perfusionKARTTUNEN, Vesa; MYLLYNEN, Päivi; PROCHAZKA, Gabriela et al.Toxicology letters. 2010, Vol 197, Num 2, pp 75-81, issn 0378-4274, 7 p.Article

Proceedings of the Final Congress of COST Action B25: Physiologically Based Pharmaco-Toxicokinetics and Dynamics, held in Athens, 26-27 May 2009GUNDERT-REMY, Ursula; MACHERAS, Panos; PELKONEN, Olavi et al.Basic & clinical pharmacology & toxicology (Print). 2010, Vol 106, Num 3, issn 1742-7835, 125 p.Conference Proceedings

Local Kinetics and Dynamics of XenobioticsPELKONEN, Olavi; KAPITULNIK, Jaime; GUNDERT-REMY, Ursula et al.Critical reviews in toxicology. 2008, Vol 38, Num 8, pp 697-720, issn 1040-8444, 24 p.Article

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