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The redox protein thioredoxin-1 regulates the constitutive and inducible expression of the estrogen metabolizing cytochromes P450 1B1 and 1A1 in MCF-7 human breast cancer cellsHUSBECK, Bryan; POWIS, Garth.Carcinogenesis (New York. Print). 2002, Vol 23, Num 10, pp 1625-1630, issn 0143-3334, 6 p.Article

Practicalities of drugging the phosphatidylinositol-3-kinase/akt cell survival signaling pathwayPOWIS, Garth; IHLE, Nathan; KIRKPATRICK, D. Lynn et al.Clinical cancer research. 2006, Vol 12, Num 10, pp 2964-2966, issn 1078-0432, 3 p.Article

Antitumor agent PX-12 inhibits HIF-1α protein levels through an Nrf2/PMF-1-mediated increase in spermidine/spermine acetyl transferaseYON HUI KIM; COON, Amy; BAKER, Amanda F et al.Cancer chemotherapy and pharmacology. 2011, Vol 68, Num 2, pp 405-413, issn 0344-5704, 9 p.Article

The Hypoxia-Associated Factor Switches Cells from HIF-1α- to HIF-2α-Dependent Signaling Promoting Stem Cell Characteristics, Aggressive Tumor Growth and InvasionMEI YEE KOH; LEMOS, Robert; XIUPING LIU et al.Cancer research (Chicago, Ill.). 2011, Vol 71, Num 11, pp 4015-4027, issn 0008-5472, 13 p.Article

The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1α protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesisWELSH, Sarah J; BELLAMY, William T; BRIEHL, Margaret M et al.Cancer research (Baltimore). 2002, Vol 62, Num 17, pp 5089-5095, issn 0008-5472, 7 p.Article

Structure-activity relationship of Aza-steroids as PI-PLC inhibitorsWENGE XIE; HAIRUO PENG; KIM, Deog-Il et al.Bioorganic & medicinal chemistry. 2001, Vol 9, Num 5, pp 1073-1083, issn 0968-0896Article

Cyclodextrin-derived diorganyl tellurides as glutathione peroxidase mimics and inhibitors of thioredoxin reductase and cancer cell growthMCNAUGHTON, Michael; ENGMAN, Lars; BIRMINGHAM, Anne et al.Journal of medicinal chemistry (Print). 2004, Vol 47, Num 1, pp 233-239, issn 0022-2623, 7 p.Article

Catalase-overexpressing thymocytes are resistant to glucocorticoid-induced apoptosis and exhibit increased net tumor growthTOME, Margaret E; BAKER, Amanda F; POWIS, Garth et al.Cancer research (Baltimore). 2001, Vol 61, Num 6, pp 2766-2773, issn 0008-5472Article

3-Deoxy-3-substituted-D-myo-inositol imidazolyl ether lipid phosphates and carbonate as inhibitors of the phosphatidylinositol 3-kinase pathway and cancer cell growthYOUHONG HU; MEUILLET, Emmanuelle J; BERGGREN, Margareta et al.Bioorganic & medicinal chemistry letters (Print). 2001, Vol 11, Num 2, pp 173-176, issn 0960-894XArticle

Hypoxia Triggers Hedgehog-Mediated Tumor―Stromal Interactions in Pancreatic CancerSPIVAK-KROIZMAN, Taly R; HOSTETTER, Galen; KIRIAKOVA, Galina M et al.Cancer research (Chicago, Ill.). 2013, Vol 73, Num 11, pp 3235-3247, issn 0008-5472, 13 p.Article

AMPKα Modulation in Cancer Progression: Multilayer Integrative Analysis of the Whole Transcriptome in Asian Gastric CancerYON HUI KIM; HAN LIANG; YONGMING SUN et al.Cancer research (Chicago, Ill.). 2012, Vol 72, Num 10, pp 2512-2521, issn 0008-5472, 10 p.Article

IL-24 is expressed during wound repair and inhibits TGFα-induced migration and proliferation of keratinocytesPOINDEXTER, Nancy J; WILLIAMS, Ryan R; POWIS, Garth et al.Experimental dermatology. 2010, Vol 19, Num 8, pp 714-722, issn 0906-6705, 9 p.Article

The thioredoxin-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide (PX-12) decreases vascular permeability in tumor xenografts monitored by dynamic contrast enhanced magnetic resonance imagingJORDAN, Bénédicte F; RUNQUIST, Matthew; RAGHUNAND, Natarajan et al.Clinical cancer research. 2005, Vol 11, Num 2, pp 529-536, issn 1078-0432, 8 p., 1Article

The skin and hair as surrogate tissues for measuring the target effect of inhibitors of phosphoinositide-3-kinase signalingWILLIAMS, Ryan; BAKER, Amanda F; IHLE, Nathan T et al.Cancer chemotherapy and pharmacology. 2006, Vol 58, Num 4, pp 444-450, issn 0344-5704, 7 p.Article

Effect of KRAS Oncogene Substitutions on Protein Behavior: Implications for Signaling and Clinical OutcomeIHLE, Nathan T; BYERS, Lauren A; LIXIA DIAO et al.Journal of the National Cancer Institute. 2012, Vol 104, Num 3, pp 228-239, issn 0027-8874, 12 p.Article

Development of sulfonamide AKT PH domain inhibitorsAHAD, Ali Md; SONG ZUOHE; DU-CUNY, Lei et al.Bioorganic & medicinal chemistry. 2011, Vol 19, Num 6, pp 2046-2054, issn 0968-0896, 9 p.Article

In vitro and In vivo Activity of Novel Small-Molecule Inhibitors Targeting the Pleckstrin Homology Domain of Protein Kinase B/AKTMOSES, Sylvestor A; AHAD ALI, M; POWIS, Garth et al.Cancer research (Chicago, Ill.). 2009, Vol 69, Num 12, issn 0008-5472, 5073-5081 [9 p.]Article

The antitumor thioredoxin-1 inhibitor PX-12 (1-methylpropyl 2-imidazolyl disulfide) decreases thioredoxin-1 and VEGF levels in cancer patient plasmaBAKER, Amanda F; DRAGOVICH, Tomislav; TATE, Wendy R et al.The Journal of laboratory and clinical medicine. 2006, Vol 147, Num 2, pp 83-90, issn 0022-2143, 8 p.Article

The hypoxic inducible stress response as a target for cancer drug discoveryWELSH, Sarah J; MEI YEE KOH; POWIS, Garth et al.Seminars in oncology. 2006, Vol 33, Num 4, pp 486-497, issn 0093-7754, 12 p.Article

Increased expression of thioredoxin-1 in human colorectal cancer is associated with decreased patient survivalRAFFEL, Jennifer; BHATTACHARYYA, Achyut K; GALLEGOS, Alfred et al.The Journal of laboratory and clinical medicine. 2003, Vol 142, Num 1, pp 46-51, issn 0022-2143, 6 p.Article

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