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Identification of 1-arylmethyl-3-(2-aminoethyl)-5-aryluracil as novel gonadotropin-releasing hormone receptor antagonistsZHU, Yun-Fei; GROSS, Timothy D; BONNEVILLE, Anne L et al.Journal of medicinal chemistry (Print). 2003, Vol 46, Num 11, pp 2023-2026, issn 0022-2623, 4 p.Article

A novel synthesis of 7-aryl-8-fluoro-pyrrolo[1,2-a]pyrimid-4-ones as potent, stable GnRH receptor antagonistsTUCCI, Fabio C; ZHU, Yun-Fei; ZHIQIANG GUO et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 23, pp 3491-3495, issn 0960-894X, 5 p.Article

Discovery of Sodium R-(+)-4-{2 [5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1 -yl] -1 -phenylethylamino}butyrate (Elagolix), a Potent and Orally Available Nonpeptide Antagonist of the Human Gonadotropin-Releasing Hormone ReceptorCHEN CHEN; DONGPEI WU; YONGSHENG CHEN et al.Journal of medicinal chemistry (Print). 2008, Vol 51, Num 23, pp 7478-7485, issn 0022-2623, 8 p.Article

Synthesis and structure-activity relationships of (R)-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils as human GnRH receptor antagonistsROWBOTTOM, Martin W; TUCCI, Fabio C; ZHU, Yun-Fei et al.Bioorganic & medicinal chemistry letters (Print). 2004, Vol 14, Num 9, pp 2269-2274, issn 0960-894X, 6 p.Article

Pharmacological characterization of a novel nonpeptide antagonist of the human gonadotropin-releasing hormone receptor, NBI-42902STRUTHERS, R. Scott; QUI XIE; MAKI, Richard A et al.Endocrinology (Philadelphia). 2007, Vol 148, Num 2, pp 857-867, issn 0013-7227, 11 p.Article

Synthesis and structure-activity relationships of 1-arylmethyl-3-(1-methyl-2-amino)ethyl-5-aryl-6-methyluracils as antagonists of the human GnRH receptorTUCCI, Fabio C; ZHU, Yun-Fei; ZHIQIANG GUO et al.Bioorganic & medicinal chemistry letters (Print). 2003, Vol 13, Num 19, pp 3317-3322, issn 0960-894X, 6 p.Article

Synthesis and initial structure-activity relationships of a novel series of imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonistsWILCOXEN, Keith M; ZHU, Yun-Fei; CONNORS, Patrick J et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 16, pp 2179-2183, issn 0960-894XArticle

Design and structure-activity relationships of 2-alkyl-3-aminomethyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1, 2-a]pyrimid-5-ones as potent GnRH receptor antagonistsZHU, Yun-Fei; ZHIQIANG GUO; SAUNDERS, John et al.Journal of medicinal chemistry (Print). 2003, Vol 46, Num 9, pp 1769-1772, issn 0022-2623, 4 p.Article

A novel synthesis of 2-arylpyrrolo[1,2-a]pyrimid-7-ones and their structure-activity relationships as potent GnRH receptor antagonistsZHU, Yun-Fei; WILCOXEN, Keith; QIU XIE et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 3, pp 403-406, issn 0960-894XArticle

Design, synthesis and structure-activity relationships of novel imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonistsGROSS, Timothy D; ZHU, Yun-Fei; SAUNDERS, John et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 16, pp 2185-2187, issn 0960-894XArticle

Initial structure-activity relationship studies of a novel series of pyrrolo[1,2-a]pyrimid-7-ones as GnRH receptor antagonistsZHU, Yun-Fei; STRUTHERS, R. Scott; CONNORS, Patrick J et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 3, pp 399-402, issn 0960-894XArticle

Determination of the binding mode of thienopyrimidinedione antagonists to the human gonadotropin releasing hormone receptor using structure-activity relationships, site-directed mutagenesis, and homology modelingBETZ, Stephen F; LIO, Francisco M; YINGHONG GAO et al.Journal of medicinal chemistry (Print). 2006, Vol 49, Num 21, pp 6170-6176, issn 0022-2623, 7 p.Article

3-[(2R)-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl) -6-methylpyrimidin-2,4-dione (NBI 42902) as a potent and orally active antagonist of the human gonadotropin-releasing hormone receptor. Design, synthesis, and in vitro and in vivo characterizationTUCCI, Fabio C; ZHU, Yun-Fei; REINHART, Greg J et al.Journal of medicinal chemistry (Print). 2005, Vol 48, Num 4, pp 1169-1178, issn 0022-2623, 10 p.Article

3-(2-aminoalkyl)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)-6-methyl-ur acils as orally bioavailable antagonists of the human gonadotropin releasing hormone receptorTUCCI, Fabio C; ZHU, Yun-Fei; TA KUNG CHEN et al.Journal of medicinal chemistry (Print). 2004, Vol 47, Num 14, pp 3483-3486, issn 0022-2623, 4 p.Article

Synthesis and structure-activity relationships of 1-arylmethyl-3-(2-aminopropyl)-5-aryl-6-methyluracils as potent GnRH receptor antagonistsZHIQIANG GUO; ZHU, Yun-Fei; TUCCI, Fabio C et al.Bioorganic & medicinal chemistry letters (Print). 2003, Vol 13, Num 19, pp 3311-3315, issn 0960-894X, 5 p.Article