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Results 1 to 25 of 55

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Characterization of the biosynthetic gene cluster of rebeccamycin from Lechevalieria aerocolonigenes ATCC 39243ONAKA, Hiroyasu; TANIGUCHI, Shin-Ichi; IGARASHI, Yasuhiro et al.Bioscience, biotechnology, and biochemistry. 2003, Vol 67, Num 1, pp 127-138, issn 0916-8451, 12 p.Article

Isolation and structure of rebeccamycin ― a new antitumor antibiotic from Nocardia aerocoligenesNETTLETON, D. E; DOYLE, T. W; KRISHNAN, B et al.Tetrahedron letters. 1985, Vol 26, Num 34, pp 4011-4014, issn 0040-4039Article

Phase I trial of rebeccamycin analog (NSC #655649) in children with refractory solid tumors: A pediatric oncology group studyLANGEVIN, Anne-Marie; WEITMAN, Steven D; KUHN, John G et al.Journal of pediatric hematology/oncology. 2003, Vol 25, Num 7, pp 526-533, issn 1077-4114, 8 p.Article

Biosynthesis of Indolocarbazole and Goadsporin, Two Different Heterocyclic Antibiotics Produced by ActinomycetesONAKA, Hiroyasu.Bioscience, biotechnology, and biochemistry. 2009, Vol 73, Num 10, pp 2149-2155, issn 0916-8451, 7 p.Article

Synthesis and biological evaluation of rebeccamycin analogues modified at the imide moietyANIMATI, Fabio; BERETTONI, Marco; BIGIONI, Mario et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 15, pp 5013-5017, issn 0960-894X, 5 p.Article

Targeting topoisomerase I cleavage to specific sequences of DNA by triple helix-forming oligonucleotide conjugates. A comparison between a rebeccamycin derivative and camptothecinARIMONDO, P. B; BAILLY, C; BOUTORINE, A et al.Comptes rendus de l'Académie des sciences. Série 3, Sciences de la vie. 1999, Vol 322, Num 9, pp 785-790, issn 0764-4469Article

A phase II study of rebeccamycin analog (NSC-655649) in metastatic renal cell cancerHUSSAIN, Maha; VAISHAMPAYAN, Ulka; HEILBRUN, Lance K et al.Investigational new drugs. 2003, Vol 21, Num 4, pp 465-471, issn 0167-6997, 7 p.Article

A phase II study of rebeccamycin analog NSC 655649 in patients with metastatic colorectal cancerGOEL, Sanjay; WADLER, Scott; HOFFMAN, Anthony et al.Investigational new drugs. 2003, Vol 21, Num 1, pp 103-107, issn 0167-6997, 5 p.Article

Production and biological activity of rebeccamycin, a novel antitumor agentBUSH, J. A; LONG, B. H; CATINO, J. J et al.Journal of antibiotics (Tokyo. 1968). 1987, Vol 40, Num 5, pp 668-678, issn 0021-8820Article

Synthesis and biological activities of indolocarbazoles bearing amino acid residuesMOREAU, Pascale; SANCELME, Martine; BAILLY, Christian et al.European journal of medicinal chemistry. 2001, Vol 36, Num 11-12, pp 887-897, issn 0223-5234Article

Carbon catabolite regulation of rebeccamycin production in Saccharothrix aerocolonigenesKING SING LAM; MATTEI, J; FORENZA, S et al.Journal of industrial microbiology. 1989, Vol 4, Num 2, pp 105-108, issn 0169-4146Article

Engineering biosynthetic pathways to generate antitumor indolocarbazole derivativesSANCHEZ, César; MENDEZ, Carmen; SALAS, José A et al.Journal of industrial microbiology & biotechnology. 2006, Vol 33, Num 7, pp 560-568, issn 1367-5435, 9 p.Conference Paper

Plasma and cerebrospinal fluid pharmacokinetics of rebeccamycin (NSC 655649) in nonhuman primatesBERG, Stacey L; ALEKSIC, Alexander; MCGUFFEY, Leticia et al.Cancer chemotherapy and pharmacology. 2004, Vol 54, Num 2, pp 127-130, issn 0344-5704, 4 p.Article

Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituentMOREAU, P; ANIZON, F; SANCELME, M et al.Journal of medicinal chemistry (Print). 1999, Vol 42, Num 4, pp 584-592, issn 0022-2623Article

Synthesis, mode of action, and biological activities of rebeccamycin bromo derivativesMOREAU, P; ANIZON, F; TAZZI, J et al.Journal of medicinal chemistry (Print). 1999, Vol 42, Num 10, pp 1816-1822, issn 0022-2623Article

A stereoselective synthesis of indole-β-N-glycosides : An application to the synthesis of rebeccamycinGALLANT, M; LINK, J. T; DANISHEFSKY, S. J et al.Journal of organic chemistry. 1993, Vol 58, Num 2, pp 343-349, issn 0022-3263Article

The biosynthetic origins of rebeccamycinPEARCE, C. J; DOYLE, T. W; FORENZA, S et al.Journal of natural products (Print). 1988, Vol 51, Num 5, pp 937-940, issn 0163-3864Article

Phase I and pharmacokinetic study of NSC 655649, a rebeccamycin analog with topoisomerase inhibitory propertiesTOLCHER, Anthony W; ECKHARDT, S. Gail; FELTON, Sally et al.Journal of clinical oncology. 2001, Vol 19, Num 11, pp 2937-2947, issn 0732-183XArticle

Cellular uptake and interaction with purified membranes of rebeccamycin derivativesGOOSSENS, J.-F; HENICHART, J.-P; ANIZON, F et al.European journal of pharmacology. 2000, Vol 389, Num 2-3, pp 141-146, issn 0014-2999Article

Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl groupANIZON, F; BELIN, L; FABBRO, D et al.Journal of medicinal chemistry (Print). 1997, Vol 40, Num 21, pp 3456-3465, issn 0022-2623Article

Synthesis and cytotoxicities of 7-aza rebeccamycin analogues bearing various substituents on the sugar moiety, on the imide nitrogen and on the carbazole frameworkMESSAOUDI, Samir; ANIZON, Fabrice; LEONCE, Stéphane et al.European journal of medicinal chemistry. 2005, Vol 40, Num 10, pp 961-971, issn 0223-5234, 11 p.Article

A TOPological Sub-structural Molecular Design (TOPS-MODE)-QSAR approach for modeling the antiproliferative activity against murine leukemia tumor cell line (L1210)MOLINA-RUIZ, Reinaldo; SAIZ-URRA, Liane; RODRIGUEZ-BORGES, J. E et al.Bioorganic & medicinal chemistry. 2009, Vol 17, Num 2, pp 537-547, issn 0968-0896, 11 p.Article

A three-step synthesis from rebeccamycin of an efficient checkpoint kinase 1 inhibitorANIZON, Fabrice; GOISTEYN, Roy M; LEONCE, Stéphane et al.European journal of medicinal chemistry. 2009, Vol 44, Num 5, pp 2234-2238, issn 0223-5234, 5 p.Article

Synthesis, and cytotoxic activity of nind-alkoxy derivatives of antibiotic arcyriarubin and dechloro-rebeccamycin aglyconLAKATOSH, S. A; BALZARINI, J; ANDREI, G et al.Journal of antibiotics (Tokyo. 1968). 2002, Vol 55, Num 8, pp 768-773, issn 0021-8820, 6 p.Article

In vitro antitumor activity of rebeccamycin analog (NSC# 655649) against pediatric solid tumorsWEITMAN, S; MOORE, R; BARRERA, H et al.Journal of pediatric hematology/oncology. 1998, Vol 20, Num 2, pp 136-139, issn 1077-4114Article

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