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Toward systematic metabolic engineering based on the analysis of metabolic regulation by the integration of different levels of informationSHIMIZU, Kazuyuki.Biochemical engineering journal. 2009, Vol 46, Num 3, pp 235-251, issn 1369-703X, 17 p.Article

The relationships between the metabolic fluxes and 13C-labeled isotopomer distribution for the flux analysis of the main metabolic pathwaysMATSUOKA, Yu; SHIMIZU, Kazuyuki.Biochemical engineering journal. 2010, Vol 49, Num 3, pp 326-336, issn 1369-703X, 11 p.Article

Metabolic flux analysis of Escherichia coli K12 grown on 13C-labeled acetate and glucose using GC-MS and powerful flux calculation methodJIAO ZHAO; SHIMIZU, Kazuyuki.Journal of biotechnology. 2003, Vol 101, Num 2, pp 101-117, issn 0168-1656, 17 p.Article

Effect of fadR gene knockout on the metabolism of Escherichia coli based on analyses of protein expressions, enzyme activities and intracellular metabolite concentrationsLIFENG PENG; SHIMIZU, Kazuyuki.Enzyme and microbial technology. 2006, Vol 38, Num 3-4, pp 512-520, issn 0141-0229, 9 p.Article

Metabolic flux analysis based on 13C-labeling experiments and integration of the information with gene and protein expression patternsSHIMIZU, Kazuyuki.Advances in biochemical engineering, biotechnology. 2004, Vol 91, pp 1-49, issn 0724-6145, 49 p.Article

Investigation into the effect of soxR and soxS genes deletion on the central metabolism of Escherichia coli based on gene expressions and enzyme activitiesMOHIUDDIN KABIR, Md; SHIMIZU, Kazuyuki.Biochemical engineering journal. 2006, Vol 30, Num 1, pp 39-47, issn 1369-703X, 9 p.Article

Gene expression patterns for metabolic pathway in pgi knockout Escherichia coli with and without phb genes based on RT-PCRMOHIUDDIN KABIR, Md; SHIMIZU, Kazuyuki.Journal of biotechnology. 2003, Vol 105, Num 1-2, pp 11-31, issn 0168-1656, 21 p.Article

Proteome analysis of a temperature-inducible recombinant Escherichia coli for poly-β-hydroxybutyrate productionKABIR, Md. Mohiuddin; SHIMIZU, Kazuyuki.Journal of bioscience and bioengineering. 2001, Vol 92, Num 3, pp 277-284, issn 1389-1723Article

Metabolic regulation of Escherichia coli and its glnG and zwf mutants under nitrogen limitationSUKMARINI, Linda; SHIMIZU, Kazuyuki.Biochemical engineering journal. 2010, Vol 48, Num 2, pp 230-236, issn 1369-703X, 7 p.Article

A possible link between Trousseau's syndrome and tissue factor producing plasma cellsSHIMIZU, Kazuyuki; ITOH, Junji.American journal of hematology. 2009, Vol 84, Num 6, pp 382-385, issn 0361-8609, 4 p.Article

Metabolic regulation analysis of icd-gene knockout Escherichia coli based on 2D electrophoresis with MALDI-TOF mass spectrometry and enzyme activity measurementsMOHIUDDIN KABIR, M; SHIMIZU, Kazuyuki.Applied microbiology and biotechnology. 2004, Vol 65, Num 1, pp 84-96, issn 0175-7598, 13 p.Article

Co-production of 3-hydroxypropionic acid and 1,3-propanediol by Klebseilla pneumoniae expressing aldH under microaerobic conditionsYANNA HUANG; ZHIMIN LI; SHIMIZU, Kazuyuki et al.Bioresource technology. 2013, Vol 128, pp 505-512, issn 0960-8524, 8 p.Article

Analysis of metabolic and physiological responses to gnd knockout in Escherichia coli by using C-13 tracer experiment and enzyme activity measurementZHAO JIAO; BABA, Tomoya; MORI, Hirotada et al.FEMS microbiology letters. 2003, Vol 220, Num 2, pp 295-301, issn 0378-1097, 7 p.Article

Improvement of vitamin B12 fermentation by reducing the inhibitory metabolites by cell recycle system and a mixed cultureMIYANO, Ken-Ichiro; YE, Kaiming; SHIMIZU, Kazuyuki et al.Biochemical engineering journal. 2000, Vol 6, Num 3, pp 207-214, issn 1369-703XArticle

Proteomic investigation on the pyk-F gene knockout Escherichia coli for aromatic amino acid productionKEDAR, Prabhakar; COLAH, Roshan; SHIMIZU, Kazuyuki et al.Enzyme and microbial technology. 2007, Vol 41, Num 4, pp 455-465, issn 0141-0229, 11 p.Article

An improved method for statistical analysis of metabolic flux analysis using isotopomer mapping matrices with analytical expressionsARAUZO-BRAVO, Marcos J; SHIMIZU, Kazuyuki.Journal of biotechnology. 2003, Vol 105, Num 1-2, pp 117-133, issn 0168-1656, 17 p.Article

Effects of glucose, vitamins, and DO concentrations on pyruvate fermentation using Torulopsis glabrata IFO 0005 with metabolic flux analysisQIANG HUA; ARAKI, Minako; KOIDE, Yohko et al.Biotechnology progress. 2001, Vol 17, Num 1, pp 62-68, issn 8756-7938Article

Simultaneous production of 3-hydroxypropionic acid and 1,3-propanediol from glycerol by a recombinant strain of Klebsiella pneumoniaeYANNA HUANG; ZHIMIN LI; SHIMIZU, Kazuyuki et al.Bioresource technology. 2012, Vol 103, Num 1, pp 351-359, issn 0960-8524, 9 p.Article

Characterization of tableting using the OSDRC systemSHIMIZU, Kazuyuki; ANDO, Masaki; NAKAYAMA, Yukiharu et al.Pharmaceutical research. 2007, Vol 24, Num 10, pp 1902-1909, issn 0724-8741, 8 p.Article

Design of metabolic regulatory structures for enhanced lysine synthesis flux using (log)linearized kinetic modelsQIANG HUA; CHEN YANG; SHIMIZU, Kazuyuki et al.Biochemical engineering journal. 2001, Vol 9, Num 1, pp 49-57, issn 1369-703XArticle

Metabolic control analysis for lysine synthesis using Corynebacterium glutamicum and experimental verificationQIANG HUA; CHEN YANG; SHIMIZU, Kazuyuki et al.Journal of bioscience and bioengineering. 2000, Vol 90, Num 2, pp 184-192, issn 1389-1723Article

Growth phase-dependent changes in the expression of global regulatory genes and associated metabolic pathways in Escherichia coliRAHMAN, Mahbuba; MOHAMMAD RUBAYET HASAN; SHIMIZU, Kazuyuki et al.Biotechnology letters. 2008, Vol 30, Num 5, pp 853-860, issn 0141-5492, 8 p.Article

Effect of poxB gene knockout on metabolism in Escherichia coli based on growth characteristics and enzyme activitiesMAI LI; SHANJING YAO; SHIMIZU, Kazuyuki et al.World journal of microbiology & biotechnology. 2007, Vol 23, Num 4, pp 573-580, issn 0959-3993, 8 p.Article

Metabolic flux analysis for a ppc mutant Escherichia coli based on 13C-labelling experiments together with enzyme activity assays and intracellular metabolite measurementsLIFENG PENG; ARAUZO-BRAVO, Marcos J; SHIMIZU, Kazuyuki et al.FEMS microbiology letters. 2004, Vol 235, Num 1, pp 17-23, issn 0378-1097, 7 p.Article

Metabolic flux analysis of Saccharomyces cerevisiae grown on glucose, glycerol or acetate by 13C-labeling experimentsHUIMIN ZHANG; SHIMIZU, Kazuyuki; SHANJING YAO et al.Biochemical engineering journal. 2003, Vol 16, Num 3, pp 211-220, issn 1369-703X, 10 p.Article

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