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Structural studies on bioactive compounds. 39: Biological consequences of the structural modification of DHFR-inhibitory 2,4-diamino-6-(4-substituted benzylamino-3-nitrophenyl)-6-ethylpyrimidines ('benzoprims')RICHARDSON, Marianne L; CROUGHTON, Karen A; MATTHEWS, Charles S et al.Journal of medicinal chemistry (Print). 2004, Vol 47, Num 16, pp 4105-4108, issn 0022-2623, 4 p.Article

Structural studies on bioactive compounds. 34. Design, synthesis, and biological evaluation of triazenyl-substituted pyrimethamine inhibitors of pneumocystis carinii dihydrofolate reductaseCHAN, David C. M; LAUGHTON, Charles A; QUEENER, Sherry F et al.Journal of medicinal chemistry (Print). 2001, Vol 44, Num 16, pp 2555-2564, issn 0022-2623Article

Investigations on the biological properties of the lipophilic DHFR-inhibitory benzoprims reveal non-folate modes of action and opportunities for anti-cancer drug designCROUGHTON, Karen A; MATTHEWS, Charles S; GRIFFIN, Roger J et al.Anti-cancer drug design. 2001, Vol 16, Num 2-3, pp 119-128, issn 0266-9536Article

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Acquired Resistance to Temozolomide in Glioma Cell Lines: Molecular Mechanisms and Potential Translational ApplicationsJIHONG ZHANG; STEVENS, Malcolm F. G; LAUGHTON, Charles A et al.Oncology. 2010, Vol 78, Num 2, pp 103-114, issn 0030-2414, 12 p.Article

The experimental antitumor agents Phortress and Doxorubicin are equiactive against human-derived breast carcinoma xenograft modelsFICHTNER, Iduna; MONKS, Anne; HOSE, Curtis et al.Breast cancer research and treatment. 2004, Vol 87, Num 1, pp 97-107, issn 0167-6806, 11 p.Article

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Novel thioredoxin inhibitors paradoxically increase hypoxia-inducible factor-α expression but decrease functional transcriptional activity, DNA binding, and degradationJONES, Dylan T; PUGH, Christopher W; WIGFIELD, Simon et al.Clinical cancer research. 2006, Vol 12, Num 18, pp 5384-5394, issn 1078-0432, 11 p.Article

Antitumour benzothiazoles. Part 20: 3'-Cyano and 3'-alkynyl-substituted 2-(4'-aminophenyl)benzothiazoles as new potent and selective analoguesHUTCHINSON, Ian; BRADSHAW, Tracey D; MATTHEWS, Charles S et al.Bioorganic & medicinal chemistry letters (Print). 2003, Vol 13, Num 3, pp 471-474, issn 0960-894X, 4 p.Article

Antitumor benzothiazoles. 16. Synthesis and pharmaceutical properties of antitumor 2-(4-aminophenyl)benzothiazole amino acid prodrugsHUTCHINSON, Ian; JENNINGS, Sharon A; RAO VISHNUVAJJALA, B et al.Journal of medicinal chemistry (Print). 2002, Vol 45, Num 3, pp 744-747, issn 0022-2623Article

Role of CYP1A1 in modulation of antitumor properties of the novel agent 2-(4-amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495) in human breast cancer cellsCHUA, Mei-Sze; KASHIYAMA, Eiji; BRADSHAW, Tracey D et al.Cancer research (Baltimore). 2000, Vol 60, Num 18, pp 5196-5203, issn 0008-5472Article

DNA Damage Persistence as Determinant of Tumor Sensitivity to the Combination of Topo I Inhibitors and Telomere-Targeting AgentsBIROCCIO, Annamaria; PORRU, Manuela; BERETTA, Giovanni et al.Clinical cancer research (Print). 2011, Vol 17, Num 8, pp 2227-2236, issn 1078-0432, 10 p.Article

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Carbene Reactivity of 4-Diazo-4H-imidazoles toward Nucleophiles and Aromatic CompoundsSMITH, Matthew R; BLAKE, Alexander J; HAYES, Christopher J et al.Journal of organic chemistry. 2009, Vol 74, Num 24, pp 9372-9380, issn 0022-3263, 9 p.Article

Semisynthesis and in vitro anticancer activities of andrographolide analoguesSRINIVASA RAO JADA; SUSENO SUBUR, Genevieve; MATTHEWS, Charlie et al.Phytochemistry. 2007, Vol 68, Num 6, pp 904-912, issn 0031-9422, 9 p.Article

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TRF2 inhibition triggers apoptosis and reduces tumourigenicity of human melanoma cellsBIROCCIO, Annamaria; RIZZO, Angela; GILSON, Eric et al.European journal of cancer (1990). 2006, Vol 42, Num 12, pp 1881-1888, issn 0959-8049, 8 p.Article

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