CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for developmentFINNEY, Brenda A; SCHWEIGHOFFER, Edina; SHEARDOWN, Steve et al.Blood. 2012, Vol 119, Num 7, pp 1747-1756, issn 0006-4971, 10 p.Article

Immunotoxicity assessment for the novel Spleen tyrosine kinase inhibitor R406YANHONG ZHU; HERLAAR, Ellen; MASUDA, Esteban S et al.Toxicology and applied pharmacology. 2007, Vol 221, Num 3, pp 268-277, issn 0041-008X, 10 p.Article

Pyrazine-based Syk kinase inhibitorsFORNS, Pilar; ESTEVE, Cristina; VIDAL, Bernat et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 8, pp 2784-2788, issn 0960-894X, 5 p.Article

Subthreshold desensitization of human basophils re―capitulates the loss of Syk and FcεRI expression characterized by other methods of desensitizationMACGLASHAN, D.Clinical and experimental allergy (Print). 2012, Vol 42, Num 7, pp 1060-1070, issn 0954-7894, 11 p.Article

Protein-tyrosine kinase Syk is required for pathogen engulfment in complement-mediated phagocytosisYUHONG SHI; TOHYAMA, Yumi; KADONO, Tomomi et al.Blood. 2006, Vol 107, Num 11, pp 4554-4562, issn 0006-4971, 9 p.Article

Spleen Tyrosine Kinase Functions as a Tumor Suppressor in Melanoma Cells by Inducing Senescence-like Growth ArrestBAILET, Olivier; FENOUILLE, Nina; DECKERT, Marcel et al.Cancer research (Chicago, Ill.). 2009, Vol 69, Num 7, pp 2748-2756, issn 0008-5472, 9 p.Article

Spleen Tyrosine Kinase Is Overexpressed and Represents a Potential Therapeutic Target in Chronic Lymphocytic LeukemiaBUCHNER, Maike; FUCKS, Simon; JUMAA, Hassan et al.Cancer research (Chicago, Ill.). 2009, Vol 69, Num 13, pp 5424-5432, issn 0008-5472, 9 p.Article

Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infectionVAN ZIFFLE, Jessica A; LOWELL, Clifford A.Blood. 2009, Vol 114, Num 23, pp 4871-4882, issn 0006-4971, 12 p.Article

A novel druglike spleen tyrosine kinase binder prevents anaphylactic shock when administered orallyMAZUC, Elsa; VILLOUTREIX, Bruno O; MALBEC, Odile et al.Journal of allergy and clinical immunology. 2008, Vol 122, Num 1, pp 188-194, issn 0091-6749, 7 p.Article

Saucerneol D inhibits eicosanoid generation and degranulation through suppression of Syk kinase in mast cellsYUE LU; YING LI; SEO, Chang-Seob et al.Food and chemical toxicology. 2012, Vol 50, Num 12, pp 4382-4388, issn 0278-6915, 7 p.Article

4-Chlorotetrazolo[1,5-α]quinoxaline inhibits activation of Syk kinase to suppress mast cells in vitro and mast cell-mediated passive cutaneous anaphylaxis in miceKUI LEA PARK; NA YOUNG KO; YOUNG MI KIM et al.Toxicology and applied pharmacology. 2011, Vol 257, Num 2, pp 235-241, issn 0041-008X, 7 p.Article

Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cellsGOBESSI, S; LAURENTI, L; LONGO, P. G et al.Leukemia. 2009, Vol 23, Num 4, pp 686-697, issn 0887-6924, 12 p.Article

Dextran sulphate induces fibrinogen receptor activation through a novel Syk-independent PI-3 kinase-mediated tyrosine kinase pathway in plateletsGETZ, Todd M; MANNE, Bhanu Kanth; BUITRAGO, Lorena et al.Thrombosis and haemostasis. 2013, Vol 109, Num 6, pp 1131-1140, issn 0340-6245, 10 p.Article

Involvement of the Syk-mTOR pathway in follicular lymphoma cell invasion and angiogenesisFRUCHON, S; KHEIRALLAH, S; SAATI, T. Al et al.Leukemia. 2012, Vol 26, Num 4, pp 795-805, issn 0887-6924, 11 p.Article

Inhibitory mechanism of saponins derived from roots of Platycodon grandiflorum on anaphylactic reaction and IgE-mediated allergic response in mast cellsEUN HEE HAN; JIN HEE PARK; JI YOUNG KIM et al.Food and chemical toxicology. 2009, Vol 47, Num 6, pp 1069-1075, issn 0278-6915, 7 p.Article

Suppression of the basophil response to allergen during treatment with omalizumab is dependent on 2 competing factorsMACGLASHAN, Donald W; SAVAGE, Jessica H; WOOD, Robert A et al.Journal of allergy and clinical immunology. 2012, Vol 130, Num 5, pp 1130-1135, issn 0091-6749, 6 p.Article

Inhibition of Syk protein tyrosine kinase induces apoptosis and blocks proliferation in T-cell non-Hodgkin's lymphoma cell linesWILCOX, R. A; SUN, D. X; NOVAK, A et al.Leukemia. 2010, Vol 24, Num 1, pp 229-232, issn 0887-6924, 4 p.Article

Spleen Tyrosine Kinase Inhibitors for Rheumatoid Arthritis: Where Are We Now?SCOTT, Ian C; SCOTT, David L.Drugs (Basel). 2014, Vol 74, Num 4, pp 415-422, issn 0012-6667, 8 p.Article

A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in plateletsTHOMAS, Dafydd H; GETZ, Todd M; NEWMAN, Tiffanny N et al.Blood. 2010, Vol 116, Num 14, pp 2570-2578, issn 0006-4971, 9 p.Article

Amplification of Toll-like receptor―mediated signaling through spleen tyrosine kinase in human B-cell activationIWATA, Shigeru; YAMAOKA, Kunihiro; NIIRO, Hiroaki et al.Journal of allergy and clinical immunology. 2012, Vol 129, Num 6, pp 1594-1601, issn 0091-6749, 8 p.Article

Selective, novel spleen tyrosine kinase (Syk) inhibitors suppress chronic lymphocytic leukemia B-cell activation and migrationHOELLENRIEGEL, J; COFFEY, G. P; BURGER, J. A et al.Leukemia. 2012, Vol 26, Num 7, pp 1576-1583, issn 0887-6924, 8 p.Article

Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemiaFRIEDBERG, Jonathan W; SHARMAN, Jeff; CRIPE, Larry D et al.Blood. 2010, Vol 115, Num 13, pp 2578-2585, issn 0006-4971, 8 p.Article

Rational combined targeting of phosphodiesterase 4B and SYK in DLBCLKIM, Sang-Woo; RAI, Deepak; MCKELLER, Morgan R et al.Blood. 2009, Vol 113, Num 24, pp 6153-6160, issn 0006-4971, 8 p.Article

Targeting SYK kinase-dependent anti-apoptotic resistance pathway in B-lineage acute lymphoblastic leukaemia (ALL) cells with a potent SYK inhibitory pentapeptide mimicUCKUN, Fatih M; EK, Rauf O; JAN, Shyi-Tai et al.British journal of haematology. 2010, Vol 149, Num 4, pp 508-517, issn 0007-1048, 10 p.Article

Syk inhibition with fostamatinib leads to transitional B lymphocyte depletionBARR, Paul M; CHUNGWEN WEI; ROGER, James et al.Clinical immunology (Orlando, Fla. Print). 2012, Vol 142, Num 3, pp 237-242, issn 1521-6616, 6 p.Article