Identification of a novel selective H₁-antihistamine with optimized pharmacokinetic properties for clinical evaluation in the treatment of insomniaMOREE, Wilna J; LI, Bin-Feng; HERNANDEZ, Lisa M et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 19, pp 5874-5878, issn 0960-894X, 5 p.Article

5-Aryluracils as potent GnRH antagonists : Characterization of atropisomersLIREN ZHAO; ZHIQIANG GUO; QIU XIE et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 11, pp 3344-3349, issn 0960-894X, 6 p.Article

Structure-activity relationship studies on a series of piperazinebenzylalcohols and their ketone and amine analogs as melanocortin-4 receptor ligandsMARINKOVIC, Dragan; TUCCI, Fabio C; TRAN, Joe A et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 17, pp 4817-4822, issn 0960-894X, 6 p.Article

Discovery of Sodium R-(+)-4-{2 [5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1 -yl] -1 -phenylethylamino}butyrate (Elagolix), a Potent and Orally Available Nonpeptide Antagonist of the Human Gonadotropin-Releasing Hormone ReceptorCHEN CHEN; DONGPEI WU; YONGSHENG CHEN et al.Journal of medicinal chemistry (Print). 2008, Vol 51, Num 23, pp 7478-7485, issn 0022-2623, 8 p.Article

Synthesis and structure-activity relationships of (R)-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils as human GnRH receptor antagonistsROWBOTTOM, Martin W; TUCCI, Fabio C; ZHU, Yun-Fei et al.Bioorganic & medicinal chemistry letters (Print). 2004, Vol 14, Num 9, pp 2269-2274, issn 0960-894X, 6 p.Article

4-{(2R)-[3-aminopropionylamido]-3-(2,4-dichlorophenyl)propionyl}-1-{2-[(2-thieny l)ethylaminomethyl]phenyl}piperazine as a potent and selective melanocortin-4 receptor antagonist-design, synthesis, and characterizationCHEN CHEN; PONTILLO, Joseph; FLECK, Beth A et al.Journal of medicinal chemistry (Print). 2004, Vol 47, Num 27, pp 6821-6830, issn 0022-2623, 10 p.Article

Structure-activity relationships of piperazinebenzylamines as potent and selective agonists of the human melanocortin-4 receptorPONTILLO, Joseph; TRAN, Joseph A; TUCCI, Fabio C et al.Bioorganic & medicinal chemistry letters (Print). 2004, Vol 14, Num 17, pp 4417-4423, issn 0960-894X, 7 p.Article

Potent and orally bioavailable zwitterion GnRH antagonists with low CYP3A4 inhibitory activityCHEN CHEN; YONGSHENG CHEN; TUCCI, Fabio C et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 11, pp 3301-3305, issn 0960-894X, 5 p.Article

Pyrrolidinones as orally bioavailable antagonists of the human melanocortin-4 receptor with anti-cachectic activityTRAN, Joe A; TUCCI, Fabio C; PONTILLO, Joseph et al.Bioorganic & medicinal chemistry. 2007, Vol 15, Num 15, pp 5166-5176, issn 0968-0896, 11 p.Article

Pyrrolidinones as potent functional antagonists of the human melanocortin-4 receptorWANLONG JIANG; TUCCI, Fabio C; JOHNS, Michael et al.Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 20, pp 5610-5613, issn 0960-894X, 4 p.Article

Synthesis and characterization of pyrrolidine derivatives as potent agonists of the human melanocortin-4 receptorWANLONG JIANG; TRAN, Joe A; FOSTER, Alan C et al.Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 23, pp 6546-6552, issn 0960-894X, 7 p.Article

Identification of agonists and antagonists of the human melanocortin-4 receptor from piperazinebenzylaminesTRAN, Joe A; PONTILLO, Joseph; FOSTER, Alan C et al.Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 3, pp 833-837, issn 0960-894X, 5 p.Article

Synthesis and structure-activity relationships of uracil derived human GnRH receptor antagonists: (R)-3-[2-(2-amino)phenethyl]-1-(2,6-difluorobenzyl)-6-methyluracils containing a substituted thiophene or thiazole at C-5ROWBOTTOM, Martin W; TUCCI, Fabio C; QIU XIE et al.Bioorganic & medicinal chemistry letters (Print). 2004, Vol 14, Num 19, pp 4967-4973, issn 0960-894X, 7 p.Article

Identification of 1-arylmethyl-3-(2-aminoethyl)-5-aryluracil as novel gonadotropin-releasing hormone receptor antagonistsZHU, Yun-Fei; GROSS, Timothy D; BONNEVILLE, Anne L et al.Journal of medicinal chemistry (Print). 2003, Vol 46, Num 11, pp 2023-2026, issn 0022-2623, 4 p.Article

A novel synthesis of 7-aryl-8-fluoro-pyrrolo[1,2-a]pyrimid-4-ones as potent, stable GnRH receptor antagonistsTUCCI, Fabio C; ZHU, Yun-Fei; ZHIQIANG GUO et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 23, pp 3491-3495, issn 0960-894X, 5 p.Article

Novel benzothiophene H₁-antihistamines for the treatment of insomniaMOREE, Wilna J; JOVIC, Florence; HERNANDEZ, Lisa M et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 7, pp 2316-2320, issn 0960-894X, 5 p.Article

Pharmacological and pharmacokinetic characterization of 2-piperazine-α-isopropyl benzylamine derivatives as melanocortin-4 receptor antagonistsCHEN CHEN; TUCCI, Fabio C; FOSTER, Alan C et al.Bioorganic & medicinal chemistry. 2008, Vol 16, Num 10, pp 5606-5618, issn 0968-0896, 13 p.Article

Synthesis and characterization of trans-4-(4-chlorophenyl) pyrrolidine-3-carboxamides of piperazinecyclohexanes as ligands for the melanocortin-4 receptorCHEN, Caroline W; TRAN, Joe A; FLECK, Beth A et al.Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 24, pp 6825-6831, issn 0960-894X, 7 p.Article

Design, synthesis, and SAR studies on a series of 2-pyridinylpiperazines as potent antagonists of the melanocortin-4 receptorTRAN, Joe A; PONTILLO, Joseph; FOSTER, Alan C et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 14, pp 3693-3696, issn 0960-894X, 4 p.Article

A convenient one-pot synthesis of asymmetric 1,3,5-triazine-2,4,6-triones and its application towards a novel class of gonadotropin-releasing hormone receptor antagonistsZHIQIANG GUO; DONGPEI WU; ZHU, Yun-Fei et al.Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 3, pp 693-698, issn 0960-894X, 6 p.Article

A potent and selective nonpeptide antagonist of the melanocortin-4 receptor induces food intake in satiated micePONTILLO, Joseph; TRAN, Joseph A; SAUNDERS, John et al.Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 10, pp 2541-2546, issn 0960-894X, 6 p.Article

Optimization of piperazinebenzylamines with a N-(1-methoxy-2-propyl) side chain as potent and selective antagonists of the human melanocortin-4 receptorPONTILLO, Joseph; MARINKOVIC, Dragan; CHEN CHEN et al.Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 20, pp 4615-4618, issn 0960-894X, 4 p.Article

Structure-activity relationships of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonistsZHIQIANG GUO; DONGPEI WU; SAID, Yang et al.Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 16, pp 3685-3690, issn 0960-894X, 6 p.Article

Design and structure-activity relationships of 2-alkyl-3-aminomethyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1, 2-a]pyrimid-5-ones as potent GnRH receptor antagonistsZHU, Yun-Fei; ZHIQIANG GUO; SAUNDERS, John et al.Journal of medicinal chemistry (Print). 2003, Vol 46, Num 9, pp 1769-1772, issn 0022-2623, 4 p.Article

A novel synthesis of 2-arylpyrrolo[1,2-a]pyrimid-7-ones and their structure-activity relationships as potent GnRH receptor antagonistsZHU, Yun-Fei; WILCOXEN, Keith; QIU XIE et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 3, pp 403-406, issn 0960-894XArticle