Covalent analogues of DNA base-pairs and triplets. Part 2: Synthesis and cytostatic activity of bis(purin-6-yl)acetylenes, -diacetylenes and related compoundsHOCEK, Michal; VOTRUBA, Ivan.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 7, pp 1055-1058, issn 0960-894XArticle

N⁶-Methyl-AMP aminohydrolase activates N⁶-substituted purine acyclic nucleoside phosphonatesSCHINKMANOUD, Markéta; VOTRUBA, Ivan; HOLY, Antonin et al.Biochemical pharmacology. 2006, Vol 71, Num 9, pp 1370-1376, issn 0006-2952, 7 p.Article

Synthesis and antiproliferative activity of 2,6-diamino-9-benzyl-9-deazapurine and related compoundsOTMAR, Miroslav; MASOJIDKOVA, Milena; VOTRUBA, Ivan et al.Bioorganic & medicinal chemistry. 2004, Vol 12, Num 12, pp 3187-3195, issn 0968-0896, 9 p.Article

Interaction of guanine phosphonomethoxyalkyl derivatives with GMP kinase isoenzymesKREJCOVD, Romana; HORSKD, Kvetoslava; VOTRUBA, Ivan et al.Biochemical pharmacology. 2000, Vol 60, Num 12, pp 1907-1913, issn 0006-2952Article

Syntheses of N³-substituted thymine acyclic nucleoside phosphonates and a comparison of their inhibitory effect towards thymidine phosphorylasePOMEISL, Karel; HOLY, Antonin; VOTRUBA, Ivan et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 4, pp 1364-1367, issn 0960-894X, 4 p.Article

Alpha anomer of 5-aza-2-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cellsHDJEK, Miroslau; VOTRUBA, Ivan; HOLY, Antonin et al.Biochemical pharmacology. 2008, Vol 75, Num 4, pp 965-972, issn 0006-2952, 8 p.Article

Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2'-C-methylribonucleosides, 2'-deoxy-2'-fluoroarabinonucleosides, arabinonucleosides and 2'-deoxyribonucleosidesNAUS, Petr; PERLIKOVA, Pavla; BOURDERIOUX, Aurelie et al.Bioorganic & medicinal chemistry. 2012, Vol 20, Num 17, pp 5202-5214, issn 0968-0896, 13 p.Article

Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAPHAJEK, Miroslav; CVILINK, Viktor; VOTRUBA, Ivan et al.European journal of pharmacology. 2010, Vol 643, Num 1, pp 6-12, issn 0014-2999, 7 p.Article

Antiviral activity of tenofovir against Cauliflower mosaic virus and its metabolism in Brassica pekinensis plantsSPAK, Josef; VOTRUBA, Ivan; PAVINGEROVA, Daniela et al.Antiviral research. 2011, Vol 92, Num 2, pp 378-381, issn 0166-3542, 4 p.Article

Role of Caspases and CD95/Fas in the Apoptotic Effects of a Nucleotide Analog PMEG in CCRF-CEM CellsMERTLIKOVA-KAISEROVA, Helena; VOTRUBA, Ivan; MATOUSOVA, Marika et al.Anticancer research. 2010, Vol 30, Num 7, pp 2791-2798, issn 0250-7005, 8 p.Article

The substrate activity of (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine diphosphate toward DNA polymerases α, δ and εBIRKUS, Gabriel; REJMAN, Dominik; OTMAR, Miroslav et al.Antiviral chemistry & chemotherapy. 2004, Vol 15, Num 1, pp 23-33, issn 0956-3202, 11 p.Article

Phosphoramidate pronucleotides of cytostatic 6-aryl-7-deazapurine ribonucleosidesPERLIKOVA, Pavla; POHL, Radek; VOTRUBA, Ivan et al.Bioorganic & medicinal chemistry. 2011, Vol 19, Num 1, pp 229-242, issn 0968-0896, 14 p.Article

Synthesis and biological activity of desmethoxy analogues of coruscanone ATICHOTOVA, Lucie; MATOUSOVA, Eliska; SPULAK, Marcel et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 20, pp 6062-6066, issn 0960-894X, 5 p.Article

Antitumour activity of a combined treatment with PMEDAP and docetaxel in the prague inbred Sprague-Dawley/cub rat strain bearing T-cell lymphomaBOBKOV, Klara; GUT, Ivan; MANDYS, Vaclav et al.Anticancer research. 2001, Vol 21, Num 4A, pp 2725-2731, issn 0250-7005Article

A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activitiesJANSA, Petr; BASZCZYNSKI, Ondřej; JANEBA, Zlatko et al.European journal of medicinal chemistry. 2011, Vol 46, Num 9, pp 3748-3754, issn 0223-5234, 7 p.Article

In vitro activities of 3-(halogenated phenyl)-5-acyloxymethyl-2,5-dihydrofuran-2-ones against common and emerging yeasts and moldsBUCHTA, Vladimir; POUR, Milan; KUBANOVA, Petra et al.Antimicrobial agents and chemotherapy. 2004, Vol 48, Num 3, pp 873-878, issn 0066-4804, 6 p.Article

Synthesis, cytostatic, and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]-, and 6-[2-(dialkylamino)vinyl]purine nucleosidesKUCHAR, Martin; HOCEK, Michal; POHL, Radek et al.Bioorganic & medicinal chemistry. 2008, Vol 16, Num 3, pp 1400-1424, issn 0968-0896, 25 p.Article

3,5-Disubstituted pyranone analogues of highly antifungally active furanones: Conversion of biological effect from antifungal to cytostaticSCHILLER, Radan; TICHOTOVA, Lucie; PAVLIK, Jan et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 24, pp 7358-7360, issn 0960-894X, 3 p.Article

Cytostatic 6-arylpurine nucleosides. 6.SAR in anti-HCV and cytostatic activity of extended series of 6-hetarylpurine ribonucleosidesHOCEK, Michal; NAUS, Petr; POHL, Radek et al.Journal of medicinal chemistry (Print). 2005, Vol 48, Num 18, pp 5869-5873, issn 0022-2623, 5 p.Article