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The pharmacology of spontaneously open α1β3ε GABAA receptor-ionophoresMAKSAY, Gabor; THOMPSON, Sally A; WAFFORD, Keith A et al.Neuropharmacology. 2003, Vol 44, Num 8, pp 994-1002, issn 0028-3908, 9 p.Article

New directions in kinetic high information content assaysSIMPSON, Peter B; WAFFORD, Keith A.Drug discovery today. 2006, Vol 11, Num 5-6, pp 237-244, issn 1359-6446, 8 p.Article

Pharmacology of GABAA receptors exhibiting different levels of spontaneous activityMORTENSEN, Martin; WAFFORD, Keith A; WINGROVE, Peter et al.European journal of pharmacology. 2003, Vol 476, Num 1-2, pp 17-24, issn 0014-2999, 8 p.Article

Activity of chlormethiazole at human recombinant GABAA and NMDA receptorsUSALA, Marcello; THOMPSON, Sally Anne; WHITING, Paul J et al.British journal of pharmacology. 2003, Vol 140, Num 6, pp 1045-1050, issn 0007-1188, 6 p.Article

Thymol, a constituent of thyme essential oil, is a positive allosteric modulator of human GABAA receptors and a homo-oligomeric GABA receptor from Drosophila melanogasterPRIESTLEY, Caroline M; WILLIAMSON, Elizabeth M; WAFFORD, Keith A et al.British journal of pharmacology. 2003, Vol 140, Num 8, pp 1363-1372, issn 0007-1188, 10 p.Article

Pharmacokinetics and metabolism studies on 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy) pyrazolo[1,5-d][1,2,4]triazine, a functionally selective GABAA α5 inverse agonist for cognitive dysfunctionJONES, Philip; ATACK, John R; SZETO, Nicola et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 4, pp 872-875, issn 0960-894X, 4 p.Article

A pyridazine series of α2/α3 subtype selective GABAAagonists for the treatment of anxietyLEWIS, Richard T; BLACKABY, Wesley P; REYNOLDS, David S et al.Journal of medicinal chemistry (Print). 2006, Vol 49, Num 8, pp 2600-2610, issn 0022-2623, 11 p.Article

Growth factors regulate the survival and fate of cells derived from human neurospheresCALDWELL, Maeve A; XIAOLING HE; WILKIE, Neil et al.Nature biotechnology. 2001, Vol 19, Num 5, pp 475-479, issn 1087-0156Article

Imidazo[1,2-a]pyrazin-8-ones, imidazo[1,2-d][1,2,4]triazin-8-ones and imidazo[2,1-f][1,2,4]triazin-8-ones as α2/α3 subtype selective GABAA agonists for the treatment of anxietyGOODACRE, Simon C; HALLETT, David J; CARLING, Robert W et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 6, pp 1582-1585, issn 0960-894X, 4 p.Article

Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABAAα2/α3 binding site agonists for the treatment of anxiety disordersGOODACRE, Simon C; STREET, Leslie J; FERRIS, Pushpinder et al.Journal of medicinal chemistry (Print). 2006, Vol 49, Num 1, pp 35-38, issn 0022-2623, 4 p.Article

Imidazo[1,2-b][1,2,4]triazines as α2/α3 subtype selective GABAA agonists for the treatment of anxietyJENNINGS, Andrew S. R; LEWIS, Richard T; SMITH, Alison J et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 6, pp 1477-1480, issn 0960-894X, 4 p.Article

Discovery of imidazo[1,2-b][1,2,4]triazines as GABAA α2/3 subtype selective agonists for the treatment of anxietyRUSSELL, Michael G. N; CARLING, Robert W; SMITH, Alison J et al.Journal of medicinal chemistry (Print). 2006, Vol 49, Num 4, pp 1235-1238, issn 0022-2623, 4 p.Article

3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues : High-affinity γ-aminobutyric acid-A benzodiazepine receptor ligands with α2, α3, and α5-subtype binding selectivity over α1CARLING, Robert W; MOORE, Kevin W; COOK, Susan M et al.Journal of medicinal chemistry (Print). 2004, Vol 47, Num 7, pp 1807-1822, issn 0022-2623, 16 p.Article

Differential contribution of GABAA receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligandsFRADLEY, Rosa L; GUSCOTT, Martin R; ROSAHL, Thomas W et al.Journal of psychopharmacology (Oxford). 2007, Vol 21, Num 4, pp 384-391, issn 0269-8811, 8 p.Article

Imidazo[1,2 -a]pyrimidines as functionally selective GABAA ligandsBLACKABY, Wesley P; ATACK, John R; STREET, Leslie J et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 5, pp 1175-1179, issn 0960-894X, 5 p.Article

The proconvulsant effects of the GABAA α5 subtype-selective compound RY-080 may not be α5-mediatedATACK, John R; BAYLEY, Peter J; FLETCHER, Stephen R et al.European journal of pharmacology. 2006, Vol 548, Num 1-3, pp 77-82, issn 0014-2999, 6 p.Article

2,3,7-trisubstituted pyrazolo[1,5-d][1,2,4]triazines : Functionally selective GABAA α3-subtype agonistsCARLING, Robert W; RUSSELL, Michael G. N; MOORE, Kevin W et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 13, pp 3550-3554, issn 0960-894X, 5 p.Article

Discovery of functionally selective 7,8,9,10-tetrahydro-7,10-ethano-1,2,4-triazolo[3,4-a ]phthalazines as GABAA receptor agonists at the α3 subunitRUSSELL, Michael G. N; CARLING, Robert W; MOORE, Kevin W et al.Journal of medicinal chemistry (Print). 2005, Vol 48, Num 5, pp 1367-1383, issn 0022-2623, 17 p.Article

Novel N1-(benzyl)cinnamamidine derived NR2B subtype-selective NMDA receptor antagonistsCURTIS, Neil R; DIGGLE, Helen J; KULAGOWSKI, Janusz J et al.Bioorganic & medicinal chemistry letters (Print). 2003, Vol 13, Num 4, pp 693-696, issn 0960-894X, 4 p.Article

Orally efficacious NR2B-selective NMDA receptor antagonistsCLAIBORNE, Christopher F; MCCAULEY, John A; BEDNAR, Rodney A et al.Bioorganic & medicinal chemistry letters (Print). 2003, Vol 13, Num 4, pp 697-700, issn 0960-894X, 4 p.Article

7-(1,1-dimethylethyl)-6-(2-ethyl-2h-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine : A functionally selective γ-aminobutyric AcidA (GABAA) α2/α3-subtype selective agonist that exhibits potent anxiolytic activity but is not sedating in animal modelsCARLING, Robert W; MADIN, Andrew; MCKERNAN, Ruth M et al.Journal of medicinal chemistry (Print). 2005, Vol 48, Num 23, pp 7089-7092, issn 0022-2623, 4 p.Article

NR2B-selective N-methyl-D-aspartate antagonists: Synthesis and evaluation of 5-substituted benzimidazolesMCCAULEY, John A; THEBERGE, Cory R; CONNOLLY, Thomas M et al.Journal of medicinal chemistry (Print). 2004, Vol 47, Num 8, pp 2089-2096, issn 0022-2623, 8 p.Article

γ-Aminobutyric acid type A receptor β2 subunit mediates the hypothermic effect of etomidate in miceCIRONE, Jennifer; ROSAHL, Thomas W; REYNOLDS, David S et al.Anesthesiology (Philadelphia). 2004, Vol 100, Num 6, pp 1438-1445, issn 0003-3022, 8 p.Article

Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazin es and analogues as subtype-selective inverse agonists for the GABAAα5 benzodiazepine binding siteSTREET, Leslie J; STERNFELD, Francine; DAWSON, Gerard R et al.Journal of medicinal chemistry (Print). 2004, Vol 47, Num 14, pp 3642-3657, issn 0022-2623, 16 p.Article

Mechanism of α-subunit selectivity of benzodiazepine pharmacology at γ-aminobutyric acid type A receptorsWINGROVE, Peter B; SAFO, Patrick; WHEAT, Lola et al.European journal of pharmacology. 2002, Vol 437, Num 1-2, pp 31-39, issn 0014-2999Article

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