A novel class of positive allosteric modulators of AMPA receptors : Design, synthesis, and structure-activity relationships of 3-biphenyl-4-yl-4-cyano-5-ethyl-1-methyl-1H-pyrrole-2-carboxylic acid, LY2059346ZARRINMAYEH, Hamideh; TROMICZAK, Eric; HORNBACK, William J et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 19, pp 5203-5206, issn 0960-894X, 4 p.Article

Design and synthesis of a novel series of 1,2-disubstituted cyclopentanes as small, potent potentiators of 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid (AMPA) receptorsSHEPHERD, Timothy A; AIKINS, James A; JARVIE, Keith R et al.Journal of medicinal chemistry (Print). 2002, Vol 45, Num 10, pp 2101-2111, issn 0022-2623Article

Discovery of the first N-substituted 4β-methyl-5-(3-hydroxyphenyl)morphan to possess highly potent and selective opioid 6 receptor antagonist activityCARROLL, F. Ivy; LI ZHANG; MASCARELLA, T. S et al.Journal of medicinal chemistry (Print). 2004, Vol 47, Num 2, pp 281-284, issn 0022-2623, 4 p.Article

Biarylpropylsulfonamides as novel, potent potentiators of 2-amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)-propanoic acid (AMPA) receptorsORNSTEIN, Paul L; ZIMMERMAN, Dennis M; BLEAKMAN, David et al.Journal of medicinal chemistry (Print). 2000, Vol 43, Num 23, pp 4354-4358, issn 0022-2623Article

Importance of phenolic address groups in opioid kappa receptor selective antagonistsTHOMAS, James B; FIX, Scott E; ROTHMAN, Richard B et al.Journal of medicinal chemistry (Print). 2004, Vol 47, Num 4, pp 1070-1073, issn 0022-2623, 4 p.Article

Discovery of an opioid κK receptor selective pure antagonist from a library of N-substituted 4β-methyl-5-(3-hydroxyphenyl)morphansTHOMAS, James B; ATKINSON, Robert N; DERSCH, Christina M et al.Journal of medicinal chemistry (Print). 2002, Vol 45, Num 16, pp 3524-3530, issn 0022-2623Article

A novel class of AMPA receptor allosteric modulators. Part 1: Design, synthesis, and SAR of 3-aryl-4-cyano-5-substituted-heteroaryl-2-carboxylic acid derivativesFERNANDEZ, Maria-Carmen; CASTANO, Ana; TROMICZAK, Eric et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 19, pp 5057-5061, issn 0960-894X, 5 p.Article

Identification of (3R)-7-hydroxy-N-((1S)-1-{[(3R, 4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidiny l]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide as a novel potent and selective opioid K receptor antagonistTHOMAS, James B; ATKINSON, Robert N; CANTRELL, Buddy E et al.Journal of medicinal chemistry (Print). 2003, Vol 46, Num 14, pp 3127-3137, issn 0022-2623, 11 p.Article

Identification of the first trans-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid k receptor antagonist activityTHOMAS, James B; ATKINSON, Robert N; ZIMMERMAN, Dennis M et al.Journal of medicinal chemistry (Print). 2001, Vol 44, Num 17, pp 2687-2690, issn 0022-2623Article